APO-Mirtazapine general information

What is APO-Mirtazapine used for?

APO-Mirtazapine tablets 30mg are used to treat episodes of major depression to relieve symptoms of depressive illness, including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.  APO-Mirtazapine tablets 30mg are also used to prevent relapse of depression.  APO-Mirtazapine tablets 30mg also have sedative properties. 

How does APO-Mirtazapine work?

APO-Mirtazapine tablets 30mg contain mirtazapine, which is an antidepressant belonging to the class of drugs known as tetracyclic antidepressant.  It is also classified as a Noradrenergic and Specific Seratonergic Antidepressant (NaSSA), because it acts as an antagonist of alpha adrenergic receptors in the central nervous system, which in turn increases the amount of noradrenaline and serotonin neurotransmitters (brain chemical that allows nerve cells to communicate).  Mirtazapine in APO-Mirtazapine tablets 30mg has several pharmacological properties, due to its interaction with several chemicals and numerous neurotransmitter systems that are thought to be involved in depression.  These include blocking the effect of histamine, which explains its sedative properties.  Also Mirtazapine in APO-Mirtazapine tablets 30mg blocks certain serotonin receptors, which prevents some of the side effects seen with antidepressants of the Selective Serotonin Reuptake Inhibitors (SSRI) and it does not have any effect as a reuptake inhibitor, which is how most SSRIs and SNRIs (Serotonin-Noradrenaline Reuptake Inhibitors) work.  The action of Mirtazapine in APO-Mirtazapine tablets 30mg helps correct the chemical imbalance caused by a lack of certain neurotransmitters that is thought to be one of the major causes of depression and other mood disorders, particularly a lack of serotonin, which controls many body activities, including regulating mood. 

What does APO-Mirtazapine contain?

APO-Mirtazapine tablets 30mg contain the active ingredient mirtazapine, a tetracyclic antidepressant classified as a Noradrenergic and Specific Seratonergic Antidepressant (NaSSA), used to treat and relieve symptoms of major depression.  They also contain lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, hypromellose, hydroxypropyl cellulose, macrogol 8000, titanium dioxide (E171), ferric oxide (red iron oxide) (E172), ferric oxide (yellow iron oxide) (E172)

Treating depression with APO-Mirtazapine

APO-Mirtazapine tablets 30mg contain mirtazapine, a tetracyclic antidepressant used to treat episodes of major depression to relieve symptoms of depressive illness, including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.  APO-Mirtazapine tablets 30mg are also used to prevent relapse of depression.  Mirtazapine in APO-Mirtazapine tablets 30mg interacts with several chemicals and numerous neurotransmitter systems that are thought to be involved in depression.  These include blocking alpha adrenergic receptors in the central nervous system, which in turn increases the amount of noradrenaline and serotonin neurotransmitters (brain chemical that allows nerve cells to communicate).  This action of Mirtazapine in APO-Mirtazapine tablets 30mg helps correct the chemical imbalance caused by a lack of these neurotransmitters, which is thought to be one of the major causes of depression and other mood disorders, particularly a lack of serotonin, which controls many body activities, including regulating mood.  Mirtazapine in APO-Mirtazapine tablets 30mg also blocks certain serotonin receptors, which prevents some of the side effects seen with antidepressants of the Selective Serotonin Reuptake Inhibitors (SSRI) and it does not have any effect as a reuptake inhibitor, which is how most SSRIs and SNRIs (Serotonin-Noradrenaline Reuptake Inhibitors) work. 

What are the side effects of APO-Mirtazapine?

The most commonly reported side effects when taking APO-Mirtazapine tablets 30mg include: increase in appetite and weight gain, lethargy, drowsiness or sleepiness, headache, tiredness, dry mouth, nausea diarrhoea, vomiting, orthostatic hypotension or dizzy spell (low blood pressure when standing up), abnormal dreams, tremor, dizziness, painful joints, back pain, muscle aches and pains, oedema (swelling due to fluid accumulation), skin rash.

When should APO-Mirtazapine not be used?

You should not use APO-Mirtazapine tablets 30mg if you:

• are allergic to mirtazapine or any ingredients in APO-Mirtazapine
• are pregnant or are breastfeeding
• have kidney or liver disease
• have had a recent heart attack or have other heart problems like angina
• have certain conditions without discussion with your doctor, including low blood pressure, diabetes, glaucoma, problems in urinating due to an enlarged prostate,
• are taking any monoamine oxidase inhibitor medications (such as phenelzine, tranylcypromine and moclobemide) as these can cause serious reactions if taken with APO-Mirtazapine
• are taking medicines that interact with APO-Mirtazapine, including other antidepressants like the SNRI venlafaxine, the SSRI fluoxetine, lithium for bipolar, St John’s wort, benzodiazepines for anxiety, anticoagulants like warfarin, the antifungal ketoconazole, cimetidine for stomach ulcers, the antibiotic erythromycin, anticonvulsant carbamazepine, the antiepileptic phenytoin, alcohol

What medications interact with APO-Mirtazapine?

Several medications interact with APO-Mirtazapine tablets 30mg and should either not be taken while you are taking APO-Mirtazapine or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with APO-Mirtazapine: monoamine oxidase inhibitor medications, like phenelzine, other antidepressants like the SNRI venlafaxine, the SSRI fluoxetine, lithium for bipolar, St John’s wort, alcohol
• Drugs that affect APO-Mirtazapine: the antifungal ketoconazole, cimetidine for stomach ulcers, the antibiotic erythromycin, anticonvulsant carbamazepine, the antiepileptic phenytoin
• Drugs that are affected by APO-Mirtazapine: benzodiazepines for anxiety, anticoagulants like warfarin

How should APO-Mirtazapine be taken?

You should take your APO-Mirtazapine tablets 30mg swallowed whole with a glass of water with or without food once daily, at the same times each day preferably at bedtime.  The dose you take and for how long depends on your doctor’s recommendations how well you are responding to treatment.  You should begin to feel an improvement within one to two weeks, with maximum effect within four weeks and you should continue to take your APO-Mirtazapine tablets 30mg for at least a further four to six months after you feel well. 

How long should you take APO-Mirtazapine?

You should take your APO-Mirtazapine tablets 30mg regularly for as long as recommended by your doctor and you should begin to feel an improvement within one to two weeks, with maximum effect within four weeks.  You should continue to take your APO-Mirtazapine tablets 30mg for at least a further four to six months after you feel well. 

Missed dose of APO-Mirtazapine

If you miss a dose of APO-Mirtazapine take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should APO-Mirtazapine be stored?

You should store your APO-Mirtazapine below 25°C in a cool dry place.  

Ethics Enalapril general information

What is Ethics Enalapril used for?

Ethics Enalapril tablets 10mg are used to treat all grades of essential hypertension, which is high blood pressure when at rest, by lowering blood pressure to normal resting levels; also for renovascular hypertension, which is a form of secondary hypertension caused by narrowing of the arteries in the kidneys.  Lowering high blood pressure reduces risk of stroke, heart attack and end organ damage such as kidney disease.  Ethics Enalapril tablets 10mg are also used to treat congestive heart failure, by helping weakened heart muscles pump more efficiently and reducing feelings of breathlessness on exertion.  They are suitable for treatment of symptomatic heart failure and asymptomatic patients with left ventricular dysfunction, to reduce risk of disease progression and need for hospitalisation in patients with congestive heart failure.  Ethics Enalapril 10 is also used to prevent heart attack in patients with left ventricular dysfunction and reduce need for hospitalisation in patients with unstable angina pectoris.  Ethics Enalapril tablets 10mg can be used alone as monotherapy or with a diuretic, which helps get rid of excess water that is retained in body tissues and can cause swelling (oedema). 

How does Ethics Enalapril work?

Ethics Enalapril tablets 10mg contain enalapril, an Angiotensin Converting Enzyme (ACE) inhibitor that prevents the formation of angiotensin II, a hormone that has several actions involved in regulating blood pressure, which is the force needed to pump blood around the body.  Angiotensin II causes salt and water retention by the kidneys, and causes blood vessels to constrict (narrow); this increases blood volume while at the same time reducing blood vessel volume, which increases blood pressure.  Enalapril in Ethics Enalapril 10 inhibits the conversion of angiotensin II from angiotensin I, which allows blood vessels to relax and widen, reducing the force needed by the heart to pump blood around the body, reducing its workload and lowering blood pressure.  This also helps weakened heart muscle, such as in congestive heart failure, to work more efficiently and reduces symptoms of breathlessness on exertion.  Ethics Enalapril tablets 10mg are rapidly absorbed into the blood and are effective within one hour, lasting for 24 hours, so that you need only take one tablet a day.

What does Ethics Enalapril contain?

Ethics Enalapril tablets contain the active ingredient enalapril maleate 10mg, an Angiotensin Converting Enzyme (ACE) inhibitor used to treat hypertension and heart failure.  They also contain lactose monohydrate, maleic acid, sodium stearyl fumarate, croscarmellose sodium, hypromellose and purified water.

Treating hypertension (high blood pressure) with Ethics Enalapril

Ethics Enalapril tablets 10mg contain enalapril, an Angiotensin Converting Enzyme (ACE) inhibitor that is used to treat primary hypertension in people with high blood pressure when at rest, who are at increased risk of cardiovascular disease, including stroke and heart attack; also for renovascular hypertension, which is a form of secondary hypertension caused by narrowing of the arteries in the kidneys.  Enalapril in Ethics Enalapril 10 inhibits the formation of angiotensin II, a hormone that has several actions involved in regulating blood pressure, which is the force needed to pump blood around the body.  Ethics Enalapril tablets 10mg relax and widen blood vessels, reducing the force needed by the heart to pump blood around the body, reducing its workload and lowering blood pressure.  Lowering blood pressure using Ethics Enalapril tablets 10mg reduces the risk of complications such as stroke and heart attack, due to high blood pressure. 

Ethics Enalapril for treating congestive heart failure

Ethics Enalapril tablets 10mg contain enalapril, an Angiotensin Converting Enzyme (ACE) inhibitor that is used to widen blood vessels and reduce the force needed for the heart to pump blood around the body.  This helps weakened heart muscle, such as in congestive heart failure, to work more efficiently and reduces symptoms of breathlessness on exertion.  You may also be prescribed a diuretic to help get rid of excess water that is retained in your body tissues and can cause swelling (oedema), as a result of congestive heart failure.

What are the side effects of Ethics Enalapril?

The most commonly reported side effects when taking Ethics Enalapril tablets 10mg include: dizziness, headache, cough, blurred vision, hypotension, hypotension, syncope (fainting), nausea, diarrhoea, muscle cramps, dyspnoea (shortness of breath).

When should Ethics Enalapril not be used?

You should not use Ethics Enalapril tablets 10mg if you:

• are allergic to enalapril or other ACE inhibitor or any ingredients in or in Ethics Enalapril
• are pregnant or are breastfeeding
• have kidney or liver disease
• have diabetes, without careful monitoring of blood glucose levels
• have hereditary or idiopathic angioedema (rapid swelling under the skin)
• are taking potassium tablets or potassium-containing salt substitutes
• are taking medications that interact with Arrow-Enalapril, including, potassium-sparing diuretics like spironolactone, lithium for mood disorders, antidiabetics like insulin, non-steroidal anti-inflammatory medicines (NSAIDs) like diclofenac or ibuprofen, lithium for mood disorders, non-steroidal anti-inflammatory medicines (NSAIDs), other antihypertensives like methyldopa, calcium entry blockers or beta blockers

What medications interact with Ethics Enalapril?

Several medications interact with Ethics Enalapril tablets 10mg and should either not be taken while you are taking Ethics Enalapril or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with Ethics Enalapril: potassium-sparing diuretics like spironolactone may cause low blood calcium, non-steroidal anti-inflammatory medicines (NSAIDs) like diclofenac or ibuprofen can cause kidney problems
• Drugs that affect Ethics Enalapril: other antihypertensives like methyldopa, calcium entry blockers or beta blockers increase the antihypertensive effect
• Drugs that are affected by Ethics Enalapril: lithium for mood disorders, antidiabetics like insulin,

How should Ethics Enalapril be taken?

You should take your Ethics Enalapril tablets 10mg with a glass of water, with or without food, once or twice daily, depending on your doctor’s recommendations and what you are being treated for.  Your dose may be increased depending on how well your respond.  Arrow-Enalapril 10 helps improve your condition but does not cure it therefore you should continue to take your Ethics Enalapril tablets 10mg for as long as your doctor recommends.  Ethics Enalapril tablets 10mg may take a few weeks to lower blood pressure and you should keep taking Ethics Enalapril tablets 10mg even if you feel well, as often there are no symptoms for high blood pressure. 

How long should you take Ethics Enalapril?

Ethics Enalapril tablets 10mg help improve your condition but do not cure it therefore you should continue to take your Ethics Enalapril tablets 10mg for as long as your doctor recommends.  Ethics Enalapril tablets 10mg may take a few weeks to lower blood pressure and you should keep taking Ethics Enalapril tablets 10mg even if you feel well, as often there are no symptoms for high blood pressure. 

Missed dose of Ethics Enalapril

If you miss a dose of Ethics Enalapril tablets 10mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Ethics Enalapril be stored?

You should store your Ethics Enalapril tablets 10mg below 25°C in a cool dry place.  

What causes ED?

Medications for ED

• Phosphodiesterase type 5 (PDE5) inhibitors
• Prostaglandins

Phosphodiesterase type 5 (PDE5) inhibitors

Prostaglandins