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Outside UK/USA: 1 877 271 6591
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Anti-Inflammatory
Our Anti-Inflammatory class of Pain medications contain oral and topical nonsteroidal anti-inflammatory drugs (NSAID) for acute and chronic pain caused by inflammation, including the newer highly specific COX-2 inhibitors with reduced side effects.

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. meloxicam, or the product name, e.g. Mobic

...Read more
Our Anti-Inflammatory class of Pain medications contain oral and topical nonsteroidal anti-inflammatory drugs (NSAID) for acute and chronic pain caused by inflammation, including the newer highly specific COX-2 inhibitors with reduced side effects.

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. meloxicam, or the product name, e.g. Mobic

...Read more

APO-Diclo (Diclofenac 75mg)
APO-Diclo (Diclofenac 75mg)

Diclofenac
Also known as Voltaren
From $0.15 per Tablet
APO-Diclo SR 100mg (diclofenac sodium)
APO-Diclo SR 100mg (diclofenac sodium)

diclofenac
Also known as Voltaren Slow Release
From $0.20 per Tablet
Brufen SR 800mg (Ibuprofen)
Brufen SR 800mg (Ibuprofen)
Ibuprofen
From $0.87 per Tablet
Celebrex 100mg
Celebrex 100mg
Celecoxib
From $0.72 per Capsule
Celebrex 200mg
Celebrex 200mg
Celecoxib
From $1.18 per Capsule
Cobix 200mg (Celecoxib)
Cobix 200mg (Celecoxib)

Celecoxib
Also known as Celebrex
From $0.97 per Capsule
Celecoxib 200mg Pfizer
Celecoxib 200mg Pfizer

Celecoxib
Also known as Celebrex (and made by the same manufacturer)
From $1.43 per Capsule
Indocap (Indomethacin) 25mg
Indocap (Indomethacin) 25mg

Indomethacin
Also known as Indocid
From $0.40 per Capsule
Indocap SR (Indomethacin 75mg)
Indocap SR (Indomethacin 75mg)

Indomethacin
Also known as Indocid
From $0.88 per Capsule
Kenacort-A 10 (by Aspen)
Kenacort-A 10 (by Aspen)
Triamcinalone acetonide
From $9.80 per Ampoule
Kenacort-A 40 (by Aspen)
Kenacort-A 40 (by Aspen)
Triamcinalone acetonide
From $20.60 per Ampoule
Melorex (Meloxicam 7.5mg)
Melorex (Meloxicam 7.5mg)
Meloxicam
Also known as Mobic or Metacam
From $1.20 per Tablet
Melorex (Meloxicam 15mg)
Melorex (Meloxicam 15mg)
Meloxicam
Also known as Mobic or Metacam
From $1.50 per Tablet
Mobic 7.5mg (Meloxicam)
Mobic 7.5mg (Meloxicam)
Meloxicam
From $1.90 per Tablet
Naprosyn SR (Naproxen 750mg)
Naprosyn SR (Naproxen 750mg)
Naproxen
From $0.59 per Tablet
Naprosyn SR (Naproxen 1000mg) 28
Naprosyn SR (Naproxen 1000mg) 28
Naproxen
From $0.87 per Tablet
Noflam 500 (Naproxen)
Noflam 500 (Naproxen)
Naproxen 500mg
Also known as Naprosyn
From $0.27 per Gram
Oruvail SR (Ketoprofen 200mg)
Oruvail SR (Ketoprofen 200mg)
Ketoprofen
Once daily slow release formula
From $1.50 per Capsule
Ponstan (mefenamic acid 250mg)
Ponstan (mefenamic acid 250mg)
On Sale
mefenamic acid 250mg
From $0.35 per Capsule
Voltaren D (Diclofenac 50mg)
Voltaren D (Diclofenac 50mg)
Diclofenac
Tablets may swallowed whole or dispersed in water first.
From $0.85 per Tablet
Voltaren Emulgel
Voltaren Emulgel
Diclofenac
From $0.31 per Gram
Voltaren 100 Suppositories
Voltaren 100 Suppositories
Diclofenac
From $1.66 per Suppositories

Inflammation and prostaglandins

Inflammation is a normal reaction to protect the body from harmful pathogens or irritants, such as chemicals, and to promote healing of damaged tissues. It is a complex process of cellular interactions of the immune system that is mediated by chemicals produced at the site of tissue damage, infection or trauma.

The process of inflammation includes the widening and increased permeability of small blood vessels, exudation of fluid into and migration of immune cells like macrophages and neutrophils into the tissues where damage, infection or irritation has occurred. The fluid causes swelling and the cells produce inflammatory chemicals like prostaglandins, interleukins and leukotrienes. These chemicals attract more inflammatory cells to help with wound healing and disposing of harmful pathogens but they also magnify the inflammatory response. In doing their job, some of these inflammatory mediators can also cause pain, swelling, fever and redness. If the inflammatory process continues beyond protecting and healing, it becomes chronic and can end up damaging normal tissues.

Inflammatory conditions

Inflammation is the cause of pain in a wide range of chronic and acute conditions, including:
  • Inflammatory joint diseases like, rheumatoid arthritis an autoimmune disease, where the lining of the joint (synovium) becomes inflamed and the bone becomes eroded; osteoarthritis, a degenerative disease of the joints caused by wear and tear where the cartilage around the bone is worn away, most commonly in the hands, feet, hips and spine; ankylosing spondylitis, an autoimmune inflammatory disease that affects joints in the spine and pelvis and can cause fusion of the spine.

  • Soft tissue injuries, such as sprains and strains that are due to trauma to the tendons, ligaments, muscles or joints.

  • Soft tissue inflammation of synovial tissue that lines the joint surfaces and cavities, including bursae (fluid-filled sac between bones and tendons), tendons and ligaments surrounding joints.

  • Menstrual pain (dysmenorrhea).

  • Post-operative pain following surgery.

Nonsteroidal anti-inflammatory drugs (NSAID)

Nonsteroidal anti-inflammatory drugs (NSAID) inhibit cyclooxygenase (COX), an enzyme involved in the synthesis of prostaglandins like PGE2, which have important functions throughout the body but are also potent inflammatory mediators and cause pain, swelling and other symptoms of inflammation. They are called nonsteroidal as corticosteroid drugs are also used to treat inflammation and these target a different enzyme in the pathway of prostaglandin synthesis.

There are two known COX enzymes, COX-1, COX-2 and there is also a variant of COX-1, known as COX-3, which is found mainly in the brain. COX-1 is present in most cells and plays an important role in many normal cell functions, including aggregation of blood platelets, which controls bleeding; protection of the stomach lining or mucosa by promoting cell growth; also in maintaining normal kidney function by regulating blood flow. COX-2 is only produced by inflammatory cells, and is induced during the inflammatory process, although it is also found in very small amounts in some tissues.

NSAID medications

NSAID medications include:
  • Ibuprofen and diclofenac that inhibit both COX-1 and COX-2, and is the cause of the more serious side effects of non-specific COX inhibitors. These include gastric bleeding and ulcers due to the inhibition of prostaglandins that are protective of the gastric mucosa and have vasodilator (cause widening of blood vessels) action which helps maintain normal blood flow. Kidney damage is also a potentially serious side effect particularly in those with impaired kidney function and again this is due to the inhibition of protective prostaglandin production by blocking COX-1.

  • Diclofenac that inhibits primarily COX-2 but also has some inhibitory effect on COX-1 and is therefore more specific as an anti-inflammatory.

  • Meloxicam and celecoxib that are specific COX-2 inhibitors and have no inhibitory action against COX-1, which makes them more effective for pain and inflammation, without the gastrointestinal or kidney side effects associated with COX-1 inhibition.
...Read more

Inflammation and prostaglandins

Inflammation is a normal reaction to protect the body from harmful pathogens or irritants, such as chemicals, and to promote healing of damaged tissues. It is a complex process of cellular interactions of the immune system that is mediated by chemicals produced at the site of tissue damage, infection or trauma.

The process of inflammation includes the widening and increased permeability of small blood vessels, exudation of fluid into and migration of immune cells like macrophages and neutrophils into the tissues where damage, infection or irritation has occurred. The fluid causes swelling and the cells produce inflammatory chemicals like prostaglandins, interleukins and leukotrienes. These chemicals attract more inflammatory cells to help with wound healing and disposing of harmful pathogens but they also magnify the inflammatory response. In doing their job, some of these inflammatory mediators can also cause pain, swelling, fever and redness. If the inflammatory process continues beyond protecting and healing, it becomes chronic and can end up damaging normal tissues.

Inflammatory conditions

Inflammation is the cause of pain in a wide range of chronic and acute conditions, including:
  • Inflammatory joint diseases like, rheumatoid arthritis an autoimmune disease, where the lining of the joint (synovium) becomes inflamed and the bone becomes eroded; osteoarthritis, a degenerative disease of the joints caused by wear and tear where the cartilage around the bone is worn away, most commonly in the hands, feet, hips and spine; ankylosing spondylitis, an autoimmune inflammatory disease that affects joints in the spine and pelvis and can cause fusion of the spine.

  • Soft tissue injuries, such as sprains and strains that are due to trauma to the tendons, ligaments, muscles or joints.

  • Soft tissue inflammation of synovial tissue that lines the joint surfaces and cavities, including bursae (fluid-filled sac between bones and tendons), tendons and ligaments surrounding joints.

  • Menstrual pain (dysmenorrhea).

  • Post-operative pain following surgery.

Nonsteroidal anti-inflammatory drugs (NSAID)

Nonsteroidal anti-inflammatory drugs (NSAID) inhibit cyclooxygenase (COX), an enzyme involved in the synthesis of prostaglandins like PGE2, which have important functions throughout the body but are also potent inflammatory mediators and cause pain, swelling and other symptoms of inflammation. They are called nonsteroidal as corticosteroid drugs are also used to treat inflammation and these target a different enzyme in the pathway of prostaglandin synthesis.

There are two known COX enzymes, COX-1, COX-2 and there is also a variant of COX-1, known as COX-3, which is found mainly in the brain. COX-1 is present in most cells and plays an important role in many normal cell functions, including aggregation of blood platelets, which controls bleeding; protection of the stomach lining or mucosa by promoting cell growth; also in maintaining normal kidney function by regulating blood flow. COX-2 is only produced by inflammatory cells, and is induced during the inflammatory process, although it is also found in very small amounts in some tissues.

NSAID medications

NSAID medications include:
  • Ibuprofen and diclofenac that inhibit both COX-1 and COX-2, and is the cause of the more serious side effects of non-specific COX inhibitors. These include gastric bleeding and ulcers due to the inhibition of prostaglandins that are protective of the gastric mucosa and have vasodilator (cause widening of blood vessels) action which helps maintain normal blood flow. Kidney damage is also a potentially serious side effect particularly in those with impaired kidney function and again this is due to the inhibition of protective prostaglandin production by blocking COX-1.

  • Diclofenac that inhibits primarily COX-2 but also has some inhibitory effect on COX-1 and is therefore more specific as an anti-inflammatory.

  • Meloxicam and celecoxib that are specific COX-2 inhibitors and have no inhibitory action against COX-1, which makes them more effective for pain and inflammation, without the gastrointestinal or kidney side effects associated with COX-1 inhibition.
...Read more

All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
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