Rcifax 400 (Rifaximin) 10 Tablets/Strip
Also known as Xifaxan
Antibiotic (rifamycin, gastrointestinal)
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Discontinued, no stock
Rcifax general information
What is Rcifax used for?
Rcifax tablets 400mg are used to treat bacterial infection of the intestines that causes travellers' diarrhoea in adults, when the diarrhoea is not accompanied by fever, blood in the stools, or 8 or more unformed (soft or liquid) stools in the last 24 hours. Rcifax tablets 400mg are only effective against non-invasive bacteria like E. coli (Escherichia coli) and not against invasive bacteria including Campylobacter, Salmonella and Shighella that cause more serious dysentery-like diarrhoea. Rcifax 400 cannot be used to treat other infections as it is not absorbed into the blood and therefore, only acts locally in the gastrointestinal tract to kill local bacteria. Rcifax tablets 400mg are also used to treat hepatic encephalopathy to reduce loss of brain function due to liver damage leading to build-up of toxins in the blood.
How does Rcifax work?
Rcifax tablets 400mg contain rifaximin, a locally acting antibiotic belonging to the rifamycin class of antibiotics. Rifaximin in Rcifax tablets 400mg works by binding to the bacterial enzyme DNA-dependent RNA polymerase and this action inhibits bacterial RNA synthesis, which prevents RNA transcription and thereby the production of bacterial proteins. A certain type of E.Coli bacteria, known as enterotoxigenic, is the most common cause of travellers' diarrhoea and is usually ingested in contaminated food and water. It produces a toxin that irritates the intestine resulting in diarrhoea but no inflammation. Rcifax tablets 400mg reduce symptoms of travellers' diarrhoea including watery stools, vomiting, stomach cramps and bloating.
What does Rcifax contain?
Rcifax tablets 400mg contain the active ingredient rifaximin, a locally acting antibiotic used to treat travellers' diarrhoea.
Treating travellers' diarrhoea with Rcifax
Rcifax tablets 400mg contain rifaximin an antibiotic that is used to treat travellers' diarrhoea in adults caused by bacterial infection of the intestines. Rcifax 400 is only effective for treating non-invasive bacteria like E.Coli that is usually ingested in contaminated food and water, resulting in diarrhoea that is not accompanied by fever, blood in the stools, or 8 or more unformed (soft or liquid) stools in the last 24 hours. It is not suitable for treating invasive bacteria that can cause inflammation resulting in more serious symptoms. Rifaximin in Rcifax tablets 400mg is not absorbed into the blood and therefore, only acts locally in the gastrointestinal tract to kill local bacteria and it works by inhibiting bacterial RNA transcription and thereby protein production. Rcifax 400 reduces symptoms including diarrhoea, vomiting, stomach cramps and bloating.
What are the side effects of Rcifax?
The most commonly reported side effects when taking Rcifax tablets 400mg include, dizziness, headache, fever, abdominal pain, constipation, defecation urgency, diarrhoea, flatulence, bloating and distension, nausea and vomiting symptoms, rectal tenesmus (feeling of incomplete defecation). Rcifax tablets 400mg can result in Clostridium difficile-associated diarrhoea (CDAD), which is a more serious form of diarrhoea ranging in severity from mild to life-threatening and is due to the changes in intestinal flora that happens when taking antibiotics.
When should Rcifax not be used?
You should not use Rcifax tablets 400mg if you:
- are allergic to rifaximin or any ingredients in Rcifax
- are pregnant or are breastfeeding
- have severe liver disease
- Have watery diarrhoea, blood in your stools, passed 8 or more unformed stools in the last 24hours or have fever
- are taking medicines that interact with Rcifax, including other rifamycin antibiotics
How should Rcifax be taken?
You should take your Rcifax tablets 400mg swallowed whole with a glass of water every 8 hours for 3 days, with or without food. You should not take your Rcifax tablets 400mg for longer than the 3 days and you should not take a second course. If symptoms do not improve you should see your doctor.
How long should you take Rcifax?
You should take your Rcifax tablets 400mg for 3 days only and you should not take a second course.
Missed dose of Rcifax
If you miss a dose of Rcifax take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.
How should Rcifax be stored?
You should store your Rcifax below 25°C in a cool dry place.