Your Country: ?
Your Currency: ?
CONTACT US
USA: 877 271 6591
UK: 0808 234 7254
Outside UK/USA: 1 877 271 6591
Your Country: ?
Your Currency: ?
Login | SHOPPING CART    (0 items)
USA: 877 271 6591
UK: 0808 234 7254
Outside UK/USA: 1 877 271 6591
Your Country: ?
Your Currency: ?
Login | SHOPPING CART    (0 items)
FREE SHIPPING TO UNITED STATES
Hepcvir (Sofosbuvir) 28 Tablets/Pack


Hepcvir (Sofosbuvir) 28 Tablets/Pack

Hepcvir (Sofosbuvir)

 

Product Name
Hepcvir (Sofosbuvir) 28 Tablets/Pack
Also known as Solvadi
Active Ingredient
Sofosbuvir 400mg
Manufacturer
Cipla Pharmaceuticals
Product Type
Hep C treatment
Product expiry date we are currently shipping
Discontinued, no stock

This product has been discontinued, but we do have alternatives below.

Other Strengths


Hepcvir tablets 400 mg contain sofosbuvir, an antiviral agent that is used in combination with other antiviral medications to treat chronic infection with Hepatitis C virus.


Hepcvir general information

What is Hepcvir used for?

Hepcvir tablets 400mg are used to treat chronic hepatitis C virus infection in adults as part of a combination therapy regimen with other antiviral medications; however, they are not effective if used as monotherapy.  Hepatitis C is a disease of the liver caused by infection with the Hepatitis C virus (HCV) that is carried in the blood.  Infection is spread by direct contact with infected blood or blood products, such as intravenous injection of drugs using unsterilised needles, tattooing or body piercing using unsterile equipment, blood transfusion or received blood products using unscreened blood, organ transplant, healthcare needle stick injury.  Infection with HCV can result in acute disease or chronic disease.  Although acute symptoms may not always appear, they can appear within a few weeks or up to 6 months after infection, ranging from mild to severe, and include abdominal pain, loss of appetite, dark coloured urine, grey coloured faeces, nausea, upset stomach, fatigue.  Acute HCV can result in jaundice, which causes yellowing of skin and the whites of the eyes.  If the virus is not cleared from the body, which does occur spontaneously in a proportion of those infected, then they can develop symptoms of chronic HCV many years after the initial infection.  Chronic HCV infection causes inflammation of the liver and can lead to other more serious diseases such as liver fibrosis (early stages of liver damage and scarring) and cirrhosis (build-up of scar tissue), liver carcinoma and liver failure requiring liver transplant.  Other parts of the body can be infected as the immune system produces antibodies to fight the infection and this can result in kidney failure and skin rash.  HCV exists in different forms known as genotypes.  Genotype 1 is the most common type of HCV genotype and is also the most difficult to treat using other treatments.  Hepcvir tablets 400mg are effective against genotypes 1, 2, 3 and 4, including those awaiting a liver transplant, but only in combination with other antiviral medications including interferon and ribavirin.  A cure from HCV infection is defined as no more detectable virus in the blood, which persists for at least 12 weeks after treatment.  Hepcvir tablets 400mg in combination with other antiviral medications reduce the amount of virus in the blood and can even cure the disease.  

How does Hepcvir work?

Hepcvir tablets 400mg contain sofosbuvir, a direct-acting antiviral agent that is used in combination with other antiviral medications to treat chronic HCV infection.  Sofosbuvir in Hepcvir tablets 400mg is a direct-acting nucleotide analogue inhibitor that blocks the action of the HCV NS5B polymerase, an enzyme that is essential to viral replication.  It is a nucleotide prodrug that is converted to its active form, the uridine analog triphosphate (GS-461203), which is incorporated into HCV RNA by the action of NS5B polymerase.  This action of sofosbuvir in Hepcvir L tablets causes chain termination of viral RNA synthesis thereby inhibiting viral replication.  Sofosbuvir in Hepcvir tablets is an effective treatment for HCV infection only when used in combination with at least one other antiviral medication.  These include interferon, which is a chemical messenger produced by host cells in response to infection by various pathogens, including viruses that stimulates the body’s own immune response, as well as directly inhibiting viral replication in infected cells.  Ribavirin is a synthetic ribonucleic analogue and is incorporated into viral RNA blocking RNA synthesis; however, it does not have any antiviral activity when used alone.  The specific combination therapy regimen for HCV infection depends on the HCV genotype and the degree of liver damage due to the infection.  The combination of Hepcvir tablets 400 mg and ribavirin or ribavirin with interferon lowers the amount of hepatitis C virus in the blood and may also lead to a cure of HCV infection over a number of weeks. 

What does Hepcvir contain?

Hepcvir L tablets contain the active ingredient sofosbuvir 400mg, an antiviral agent that is used in combination with other anitvirals to treat chronic Hepatitis C virus (HCV) infection.  They also contain the colours titanium dioxide IP and Sunset Yellow FCF Aluminium Lake.  

Treating Hepatitis C infection with Hepcvir

Hepcvir tablets 400 mg contain sofosbuvir, a direct-acting antiviral agent that is used in combination with other antiviral medications to treat chronic HCV infection.  Hepatitis C is a disease of the liver caused by infection with the Hepatitis C virus (HCV) that is carried in the blood.  Infection is spread by direct contact with infected blood or blood products, such as intravenous injection of drugs using unsterilised needles, tattooing or body piercing using unsterile equipment, blood transfusion or received blood products using unscreened blood, organ transplant, healthcare needle stick injury.  Chronic HCV infection develops if the initial infection is not cleared from the body and causes inflammation of the liver and can lead to other more serious diseases such as liver fibrosis (early stages of liver damage and scarring) and cirrhosis (build-up of scar tissue), liver carcinoma and liver failure requiring liver transplant.  Other parts of the body can be infected as the immune system produces antibodies to fight the infection and this can result in kidney failure and skin rash.  Hepcvir tablets 400 mg are effective for treating genotypes 1, 2, 3 and 4 which are all different forms of Hepatitis C virus, even if the liver is damaged by cirrhosis.  Hepcvir tablets 400 mg work by blocking the replication of the virus thereby, lowering the amount of virus in the blood and may also lead to a cure of HCV infection over a number of weeks, which is no more virus is detected in the blood, which persists for at least 12 weeks after treatment. 

What are the side effects of Hepcvir?

The most commonly reported side effects when taking Hepcvir tablets 400mg depend on the combination therapy regimen and may be due to either ribavirin or interferon; they include, nausea, diarrhoea, vomiting, headache, rash, cough, weakness (asthenia) and fatigue, irritability, insomnia, fever, chills, flu-like symptoms,

When should Hepcvir not be used?

You should not use Hepcvir tablets 400mg if you:

  • are allergic to sofosbuvir, interferon or ribavirin or any ingredients in Hepcvir
  • are allergic to interferon or ribavirin that are used in combination with Hepcvir
  • are pregnant or are breastfeeding
  • have kidney or liver disease other than hepatitis C
  • are taking medicines that interact with Hepcvir including the antiarrhythmic amiodarone, anticonvulsants like carbamazepine and phenytoin, the antibacterial rifampicin, St. John’s wort, some antivirals for HIV like tenofovir

Note:  Any contraindication or precautions that apply to the combination therapy regimen with ribavirin or interferon should be considered when taking Hepcvir tablets 400mg.

What medications interact with Hepcvir?

Several medications interact with Hepcvir tablets 400mg and should either not be taken while you are taking Hepcvir or only after discussion and instruction from your doctor:

  • Drugs that cause a serious reaction with Hepcvir: the antiarrhythmic amiodarone can cause severe bradycardia (slow heartbeat)
  • Drugs that affect Hepcvir: anticonvulsants like carbamazepine and phenytoin, the antibacterial rifampicin, St. John’s wort
  • Drugs that are affected by Hepcvir: some antivirals for HIV like tenofovir,

How should Hepcvir be taken?

You should take your Hepcvir tablets 400mg swallowed whole with a glass of water once daily with or without food at the same time each day and in combination with the other antiviral drug prescribed.  You should continue to take your Hepcvir tablets 400mg for as long as recommended by your doctor, which is usually 12-24 weeks, depending on HCV genotype causing the infection and the amount of liver damage.

How long should you take Hepcvir?

You should continue to take your Hepcvir tablets 400mg for as long as recommended by your doctor, which is usually 12-24 weeks, depending on HCV genotype causing the infection and the amount of liver damage.

Missed dose of Hepcvir

If you miss a dose of Hepcvir tablets 400mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Hepcvir be stored?

You should store your Hepcvir tablets 400mg below 25°C in a cool dry place. 

 

See more products in
All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
What is this ?
Please select your country to display all the products we are able to supply to you.
What is this ?
Select the currency that you would like to display the prices in. This will be the currency that appears on your credit card statement.
 

This website uses cookies. View our policy and select your preferences here