APO-Frovatriptan (Frovatriptan) 6 Tablets/Pack
Also known as Frova
Anti-migraine (serotonin agonist)
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Discontinued, no stock
Apo-Frovatriptan general information
What is Apo-Frovatriptan used for?
Apo-Frovatriptan tablets 2.5mg are used to relieve acute migraine attacks with or without aura, which is the perception of visual disturbances and/or smells and is usually the first sign that a migraine headache is on its way. Migraine is a common neurovascular disorder, characterised by severe throbbing pain, usually on just one side of the head and often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. Physiological and psychological changes, such as neck stiffness, food cravings, increased thirst and mood changes, warn of an imminent migraine attack and this is known as the prodrome. There are many possible migraine triggers including hormonal changes in women particularly related to the menstrual cycle or taking oral contraceptives, certain foods and drinks such as chees and caffeine, stress, bright lights and chemical smells. Apo-Frovatriptan tablets 2.5mg should only be used for treatment of a migraine attack, once a clear diagnosis of migraine has been made, to relieve headache and other symptoms. Apo-Frovatriptan tablets 2.5mg can be used at any stage of a migraine attack but it is more effective if taken as soon as possible after the first signs of headache and/or aura. Apo-Frovatriptan tablets 2.5mg are not intended for the treatment of other types of headache, such as cluster headache, which is a very painful type of headache that occurs in regular cycles or clusters interspersed with periods of remission; or the management of haemiplegic migraine, which can also cause temporary weakness of one side of the body and paralysis; or basilar migraine, which is another form of migraine and is caused by an arterial spasm at the base of the brain restricting blood flow to the brain.
How does Apo-Frovatriptan work?
Apo-Frovatriptan tablets 2.5mg contain frovatriptan, which is a member of the group of drugs called tryptans and is a serotonin agonist that mimics the action of serotonin (also known as 5-hydroxytryptamine, or 5-HT). Serotonin is a brain chemical that is involved in control of mood, pain sensation, sexual behaviour, sleep, as well as dilation (widening) and constriction (narrowing) of blood vessels. Migraine is thought to be caused by dilatation or widening of blood vessels in the head (intracranial vessels) due to one of many migraine triggers, which in turn stimulates nearby sensory trigeminal nerves, which release chemicals, causing pain and inflammation. Frovatriptan in Apo-Frovatriptan tablets 2.5mg stimulates the serotonin receptors in these expanded blood vessels making them narrow again (vasoconstriction) and inhibits trigeminal nerve activity and pain transmission, relieving pain. Both actions are thought to contribute to the anti-migraine action of frovatriptan and relieve headache and other symptoms of a migraine attack, including nausea and sensitivity to light and noise. Apo-Frovatriptan tablets 2.5mg are slower acting than some of the other triptans available, being effective in relieving the pain of migraine headache within 2-3 hours, however, they are also longer lasting1,2. This mode of action of frovatriptan is thought to be favourable for slow onset migraine attacks with prodrome, and for those who are prone to relapse and recurrent migraine1,2, 3.
What does Apo-Frovatriptan contain?
Apo-Frovatriptan tablets contain the active ingredient frovatriptan tablets 2.5mg, a serotonin agonist used to relieve symptoms of a migraine attack.
Treating migraine headache with Apo-Frovatriptan
Apo-Frovatriptan tablets 2.5mg contain frovatriptan, a serotonin agonist that mimics the action of serotonin and is used to relieve acute migraine attacks. Migraine attacks can occur with or without aura, (perception of visual disturbances and/or smells) and is usually the first sign that a migraine headache is on its way; also the prodrome (certain physiological and psychological changes) can warn of an imminent migraine attack. Migraine is a common neurovascular disorder and is thought to be caused by dilatation or widening of blood vessels in the head due to one of many triggers, and the stimulation of nearby sensory trigeminal nerves, which release chemicals, causing pain and inflammation. Apo-Frovatriptan tablets 2.5mg stimulates the serotonin receptors in these expanded blood vessels making them narrow again (vasoconstriction) and inhibits trigeminal nerve activity, relieving pain. Both actions are thought to contribute to the anti-migraine action of frovatriptan in Apo-Frovatriptan tablets 2.5mg, to relieve the severe throbbing pain and headache of migraine attack, as well as other symptoms, including nausea and extreme sensitivity to light and sound.
What are the side effects of Apo-Frovatriptan?
The most commonly reported side effects when taking Apo-Frovatriptan tablets 2.5mg include abdominal pain, heartburn (dyspepsia), increased sweating (hyperhidrosis) dizziness, drowsiness, sensory disturbance including, tingling, pricking, or numbness of the skin (paraesthesia), loss of sensitivity to pain or touch (hypoaesthesia), shortness of breath, sensations of heaviness, pain, flushing, sensations of heat or cold, throat tightness, pressure or tightness, weakness, fatigue, decrease mental acuity.
When should Apo-Frovatriptan not be used?
You should not use Apo-Frovatriptan tablets 2.5mg if you:
- are allergic to frovatriptan or any triptan like sumatriptan or any ingredients in Apo-Frovatriptan
- are pregnant or are breastfeeding, without discussion with your doctor
- have had myocardial infarction or have ischaemic heart disease, coronary vasospasm (Prinzmetal's angina), peripheral vascular disease, or a history of cerebovascular accident (CVA) or transient ischaemic attack (TIA)
- have liver disease
- have uncontrolled hypertension
- have basilar or haemiplegic migraine
- are taking medicines that interact with Apo-Frovatriptan including: ergotamine or derivatives of ergotamine (including methysergide), monoamine oxidase inhibitors (MAOIs), SSRI antidepressants
What medications interact with Apo-Frovatriptan?
Several medications interact with Apo-Frovatriptan 2 tablets.5mg and should either not be taken while you are taking Apo-Frovatriptan or only after discussion and instruction from your doctor:
Drugs that cause a serious reaction with Apo-Frovatriptan:
- Ergot derivatives including methysergide (also for migraine headaches) should not be taken 24 hours before to 6 hours after dose of Apo-Frovatriptan
- MAOI antidepressants should not be taken within 14 days of Apo-Frovatriptan
- Other triptan serotonin agonist like sumatriptan
- Other serotonin agonist antidepressants like SSRIs; SNRIs.
How should Apo-Frovatriptan be taken?
You can take your Apo-Frovatriptan tablets 2.5mg at any stage of a migraine attack but it is more effective if taken as soon as possible after the first signs of headache and/or aura. You should take your Apo-Frovatriptan 2.5mg swallowed whole without food, as food may delay the effectiveness of Apo-Frovatriptan 2.5mg. If the first dose of Apo-Frovatriptan 2.5mg does not help your migraine, you should not take another dose for the same migraine, as it is unlikely that it will improve your headache. If you have another migraine attack in the next 24 hours you can take another dose, but not within two hours of the first dose and you should not take more than 30mg within 24 hours.
How should Apo-Frovatriptan be stored?
You should store your Apo-Frovatriptan tablets 2.5mg below 25°C in a cool dry place.
- Allais G, Benedetto C. Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine. Drug Des Devel Ther. 2016 Oct 3;10:3225-3236.
- Balbisi E. Frovatriptan: A Review of Pharmacology, Pharmacokinetics and Clinical Potential in the Treatment of Menstrual Migraine. Ther Clin Risk Manag 2006 Sep; 2(3): 303–308
- Evers S, Savi L, Omboni S, Lisotto C, Zanchin G, Pinessi L. Efficacy of frovatriptan as compared to other triptans in migraine with aura. J Headache Pain. 2015;16:514.