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Allopurinol-Apotex 300mg 500's

Apo-Allopurinol general information

What is Apo-Allopurinol used for?

Apo-Allopurinol tablets 300mg are used to treat several conditions that are caused by a build up of uric acid in the blood (hyperuricaemia) and the deposition of uric acid crystals throughout the body. These conditions include idiopathic gout (without known cause) or gouty arthritis, in which uric acid crystals are deposited in joints causing pain and swelling; kidney stones or uric acid nephrolithiasis (uric acid crystals in the kidney) and skin tophi (uric acid crystals beneath the skin). Apo-Allopurinol tablets 300mg are also used for clinical conditions where there is a risk of uric acid build up and deposition, particularly as a result of chemotherapy or radiation therapy for cancer, which can lead to acute uric acid nephropathy, due to high levels of uric acid in the urine (hyperuricosuria) causing loss of kidney function. Overproduction of uric acid may also be caused by certain tumours with high cell turnover rates like leukaemia or lymphoma. Other rare conditions due to high levels of uric acid in the blood are caused by overproduction of certain enzymes such as hypoxanthine-guanine phosphoribosyltransferase, which causes Lesch-Nyhan syndrome and adenine phosphoribosyltransferase which can cause kidney stones. Kidney stones can also be caused by deposition of a mixture of crystals, such those including calcium oxalate along with high levels of uric acid in the urine and Apo-Allopurinol tablets 300mg can be used to treat these kidney stones when other treatments such as increased fluid intake and dietary changes have failed.

How does Apo-Allopurinol work?

Apo-Allopurinol tablets 300mg contain allopurinol, an inhibitor of the enzyme xanthine oxidase, which plays an important role in the production of uric acid, the end product of purine metabolism. Purines are obtained from the diet mainly from meat, meat products and seafood, but are also synthesised in the body. Xanthine oxidase catalyses the conversion of hypoxanthine to xanthine and xanthine to uric acid, the final oxidation product of purine metabolism excreted in the urine. Inhibition of xanthine oxidase by allopurinol in Apo-Allopurinol tablets 300mg reduces the levels of uric acid in the blood and this helps prevent deposition of uric acid crystals in the joints. Levels of hypoxanthine and xanthine increase as they are not metabolised to uric acid and this induces a negative feedback mechanism on the synthesis of purines, which further reduces the amount of uric acid in the blood. The inhibitory action of allopurinol in Apo-Allopurinol tablets 300mg on the purine metabolic cycle (synthesis and breakdown) prevents the build up of uric acid and thereby reduces the amount of uric acid crystals that are deposited in the joints, reducing the frequency of attacks of gout and acute gouty arthritis to improve joint mobility. This action of allopurinol in Apo-Allopurinol tablets 300mg also allows skin tophi to heal and resolve and prevents the formation of kidney stones, which thereby prevents kidney damage.

What does Apo-Allopurinol contain?

Apo-Allopurinol tablets 300mg contain the active ingredient allopurinol, an inhibitor of the enzyme xanthine oxidase that is used to treat conditions caused by deposition of uric acid crystals including gout, gouty arthritis and kidney stones.

Treating gout with Apo-Allopurinol

Apo-Allopurinol tablets 300mg contain the active ingredient allopurinol that helps reduce levels of uric acid in the blood (hyperuricaemia) which can lead to deposition of uric acid crystals in joints. This is the cause of the condition known as gout resulting in painful swollen joints with loss of joint mobility. Allopurinol in Apo-Allopurinol tablets 300mg inhibits the enzyme xanthine oxidase, which plays an important role in the production of uric acid, the end product of purine metabolism. Purines are obtained from the diet mainly from meat, meat products and seafood, but are also synthesised in the body. Xanthine oxidase catalyses the conversion of hypoxanthine to xanthine and xanthine to uric acid, the final oxidation product of purine metabolism, excreted in the urine. Inhibition of xanthine oxidase by allopurinol in Apo-Allopurinol tablets 300mg reduces the levels of uric acid in the blood by preventing metabolism of purines into uric acid as well as preventing new synthesis of purines. Both mechanisms reduce the formation and accumulation of uric acid in the blood, which helps prevent deposition of uric acid crystals in the joints. Apo-Allopurinol tablets 300mg is used to treat gout to relieve the pain, swelling and loss of mobility in the affected joint, but are not used to treat an acute attack of gout.

Apo-Allopurinol for kidney stones

Apo-Allopurinol tablets 300mg contain the active ingredient allopurinol that helps reduce levels of uric acid in the blood (hyperuricaemia) that can lead to deposition of uric acid crystals in the kidneys causing kidney stones or uric acid nephrolithiasis. Allopurinol in Apo-Allopurinol tablets 300mg inhibits the enzyme xanthine oxidase, which plays an important role in the production of uric acid, the end product of purines metabolism. Purines are obtained from the diet mainly from meat, meat products and seafood, but are also synthesised in the body. Xanthine oxidase catalyses the conversion of hypoxanthine to xanthine and xanthine to uric acid, the final oxidation product of purine metabolism, excreted in the urine. Inhibition of xanthine oxidase by allopurinol in Apo-Allopurinol tablets 300mg reduces the levels of uric acid in the blood by preventing metabolism of purines into uric acid as well as preventing new synthesis of purines. Both mechanisms reduce the formation and accumulation of uric acid in the blood, which helps prevent deposition of uric acid crystals in the kidneys. Some kidney stones are caused by deposition of a mixture of crystals, such those including calcium oxalate along with high levels of uric acid in the urine and Apo-Allopurinol tablets 300mg can be used to treat these kidney stones when other treatments such as increased fluid intake and dietary changes have failed.

What are the side effects of Apo-Allopurinol?

The most commonly reported side effects when taking Apo-Allopurinol tablets 300mg include: skin rash, itching, generalised hypersensitivity reaction, gastrointestinal upset mainly nausea and vomiting. Less common but more serious reactions include liver dysfunction, tingling or numbness of the hands or feet (paraesthesia).

When should Apo-Allopurinol not be used?

You should not use Apo-Allopurinol tablets 300mg if you:
  • are allergic to allopurinol or any ingredients in Apo-Allopurinol
  • are pregnant or are breastfeeding, without discussion with your doctor
  • have kidney or liver disease
  • are having an acute attack of gout
  • have or an immediate relative has haemochromatosis, (too much iron in the body), and are also taking iron salts
  • are taking medicines that interact with Apo-Allopurinol, including: the immunosuppressants cyclosporin and azathioprine, 6-mercaptopurine for cancer treatment, the antiviral vidarabine, aspirin and other salicylates, probenecid for gout, chlorpropamide for diabetes, the antibiotics ampicillin and amoxicillin, phenytoin for epilepsy, theophylline for asthma

What medications interact with Apo-Allopurinol?

Several medications interact with Apo-Allopurinol tablets 300mg and should either not be taken while you are taking Apo-Allopurinol or only after discussion and instruction from your doctor:
  • Drugs that cause a serious reaction or increased side effects with Apo-Allopurinol: chlorpropamide for diabetes, the antibiotics ampicillin and amoxicillin
  • Drugs that affect Apo-Allopurinol: aspirin and other salicylates, probenecid for gout,
  • Drugs that are affected by Apo-Allopurinol: the immunosuppressants cyclosporin and azathioprine, 6-mercaptopurine for cancer treatment, the antiviral vidarabine, phenytoin for epilepsy, theophylline for asthma

How should Apo-Allopurinol be taken?

You should take your Apo-Allopurinol tablets 300mg once daily with a glass of water and after a meal to reduce risk of gastrointestinal side effects. The dose you take depends on your conditions, your age and your doctor’s recommendations. You should continue to take your Apo-Allopurinol tablets 300mg daily until your condition improves or for as long as your doctor recommends.

How long should you take Apo-Allopurinol?

You should continue to take your Apo-Allopurinol tablets 300mg daily until your condition improves or for as long as your doctor recommends.

Missed dose of Apo-Allopurinol

If you miss a dose of Apo-Allopurinol tablets 300mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Apo-Allopurinol be stored?

You should store your Apo-Allopurinol tablets 300mg below 25°C in a cool dry place.


ApotexAnti-uricaemic (gout)
Out Of StockGBPInhousePharmacy.vuNewOut of Stock1Allopurinol-Apotex 300mg 500 Tablets/Pack
Allopurinol-Apotex 300mg 500's


Allopurinol-Apotex 300mg 500's

Allopurinol-Apotex 300mg 500's

 
.

Product Name
Allopurinol-Apotex 300mg 500 Tablets/Pack
Active Ingredient
Allopurinol 300mg
Manufacturer
Apotex
Product Type
Anti-uricaemic (gout)
Product expiry date we are currently shipping
Discontinued, no stock
Product Price List
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This product has been discontinued, but we do have alternatives below.

Apo-Allopurinol tablets 300mg contain allopurinol, an inhibitor of the enzyme xanthine oxidase that helps reduce levels of uric acid in the blood (hyperuricaemia) and is used to treat conditions caused by deposition of uric acid crystals including gout, gouty arthritis and kidney stones.

Apo-Allopurinol general information

What is Apo-Allopurinol used for?

Apo-Allopurinol tablets 300mg are used to treat several conditions that are caused by a build up of uric acid in the blood (hyperuricaemia) and the deposition of uric acid crystals throughout the body. These conditions include idiopathic gout (without known cause) or gouty arthritis, in which uric acid crystals are deposited in joints causing pain and swelling; kidney stones or uric acid nephrolithiasis (uric acid crystals in the kidney) and skin tophi (uric acid crystals beneath the skin). Apo-Allopurinol tablets 300mg are also used for clinical conditions where there is a risk of uric acid build up and deposition, particularly as a result of chemotherapy or radiation therapy for cancer, which can lead to acute uric acid nephropathy, due to high levels of uric acid in the urine (hyperuricosuria) causing loss of kidney function. Overproduction of uric acid may also be caused by certain tumours with high cell turnover rates like leukaemia or lymphoma. Other rare conditions due to high levels of uric acid in the blood are caused by overproduction of certain enzymes such as hypoxanthine-guanine phosphoribosyltransferase, which causes Lesch-Nyhan syndrome and adenine phosphoribosyltransferase which can cause kidney stones. Kidney stones can also be caused by deposition of a mixture of crystals, such those including calcium oxalate along with high levels of uric acid in the urine and Apo-Allopurinol tablets 300mg can be used to treat these kidney stones when other treatments such as increased fluid intake and dietary changes have failed.

How does Apo-Allopurinol work?

Apo-Allopurinol tablets 300mg contain allopurinol, an inhibitor of the enzyme xanthine oxidase, which plays an important role in the production of uric acid, the end product of purine metabolism. Purines are obtained from the diet mainly from meat, meat products and seafood, but are also synthesised in the body. Xanthine oxidase catalyses the conversion of hypoxanthine to xanthine and xanthine to uric acid, the final oxidation product of purine metabolism excreted in the urine. Inhibition of xanthine oxidase by allopurinol in Apo-Allopurinol tablets 300mg reduces the levels of uric acid in the blood and this helps prevent deposition of uric acid crystals in the joints. Levels of hypoxanthine and xanthine increase as they are not metabolised to uric acid and this induces a negative feedback mechanism on the synthesis of purines, which further reduces the amount of uric acid in the blood. The inhibitory action of allopurinol in Apo-Allopurinol tablets 300mg on the purine metabolic cycle (synthesis and breakdown) prevents the build up of uric acid and thereby reduces the amount of uric acid crystals that are deposited in the joints, reducing the frequency of attacks of gout and acute gouty arthritis to improve joint mobility. This action of allopurinol in Apo-Allopurinol tablets 300mg also allows skin tophi to heal and resolve and prevents the formation of kidney stones, which thereby prevents kidney damage.

What does Apo-Allopurinol contain?

Apo-Allopurinol tablets 300mg contain the active ingredient allopurinol, an inhibitor of the enzyme xanthine oxidase that is used to treat conditions caused by deposition of uric acid crystals including gout, gouty arthritis and kidney stones.

Treating gout with Apo-Allopurinol

Apo-Allopurinol tablets 300mg contain the active ingredient allopurinol that helps reduce levels of uric acid in the blood (hyperuricaemia) which can lead to deposition of uric acid crystals in joints. This is the cause of the condition known as gout resulting in painful swollen joints with loss of joint mobility. Allopurinol in Apo-Allopurinol tablets 300mg inhibits the enzyme xanthine oxidase, which plays an important role in the production of uric acid, the end product of purine metabolism. Purines are obtained from the diet mainly from meat, meat products and seafood, but are also synthesised in the body. Xanthine oxidase catalyses the conversion of hypoxanthine to xanthine and xanthine to uric acid, the final oxidation product of purine metabolism, excreted in the urine. Inhibition of xanthine oxidase by allopurinol in Apo-Allopurinol tablets 300mg reduces the levels of uric acid in the blood by preventing metabolism of purines into uric acid as well as preventing new synthesis of purines. Both mechanisms reduce the formation and accumulation of uric acid in the blood, which helps prevent deposition of uric acid crystals in the joints. Apo-Allopurinol tablets 300mg is used to treat gout to relieve the pain, swelling and loss of mobility in the affected joint, but are not used to treat an acute attack of gout.

Apo-Allopurinol for kidney stones

Apo-Allopurinol tablets 300mg contain the active ingredient allopurinol that helps reduce levels of uric acid in the blood (hyperuricaemia) that can lead to deposition of uric acid crystals in the kidneys causing kidney stones or uric acid nephrolithiasis. Allopurinol in Apo-Allopurinol tablets 300mg inhibits the enzyme xanthine oxidase, which plays an important role in the production of uric acid, the end product of purines metabolism. Purines are obtained from the diet mainly from meat, meat products and seafood, but are also synthesised in the body. Xanthine oxidase catalyses the conversion of hypoxanthine to xanthine and xanthine to uric acid, the final oxidation product of purine metabolism, excreted in the urine. Inhibition of xanthine oxidase by allopurinol in Apo-Allopurinol tablets 300mg reduces the levels of uric acid in the blood by preventing metabolism of purines into uric acid as well as preventing new synthesis of purines. Both mechanisms reduce the formation and accumulation of uric acid in the blood, which helps prevent deposition of uric acid crystals in the kidneys. Some kidney stones are caused by deposition of a mixture of crystals, such those including calcium oxalate along with high levels of uric acid in the urine and Apo-Allopurinol tablets 300mg can be used to treat these kidney stones when other treatments such as increased fluid intake and dietary changes have failed.

What are the side effects of Apo-Allopurinol?

The most commonly reported side effects when taking Apo-Allopurinol tablets 300mg include: skin rash, itching, generalised hypersensitivity reaction, gastrointestinal upset mainly nausea and vomiting. Less common but more serious reactions include liver dysfunction, tingling or numbness of the hands or feet (paraesthesia).

When should Apo-Allopurinol not be used?

You should not use Apo-Allopurinol tablets 300mg if you:
  • are allergic to allopurinol or any ingredients in Apo-Allopurinol
  • are pregnant or are breastfeeding, without discussion with your doctor
  • have kidney or liver disease
  • are having an acute attack of gout
  • have or an immediate relative has haemochromatosis, (too much iron in the body), and are also taking iron salts
  • are taking medicines that interact with Apo-Allopurinol, including: the immunosuppressants cyclosporin and azathioprine, 6-mercaptopurine for cancer treatment, the antiviral vidarabine, aspirin and other salicylates, probenecid for gout, chlorpropamide for diabetes, the antibiotics ampicillin and amoxicillin, phenytoin for epilepsy, theophylline for asthma

What medications interact with Apo-Allopurinol?

Several medications interact with Apo-Allopurinol tablets 300mg and should either not be taken while you are taking Apo-Allopurinol or only after discussion and instruction from your doctor:
  • Drugs that cause a serious reaction or increased side effects with Apo-Allopurinol: chlorpropamide for diabetes, the antibiotics ampicillin and amoxicillin
  • Drugs that affect Apo-Allopurinol: aspirin and other salicylates, probenecid for gout,
  • Drugs that are affected by Apo-Allopurinol: the immunosuppressants cyclosporin and azathioprine, 6-mercaptopurine for cancer treatment, the antiviral vidarabine, phenytoin for epilepsy, theophylline for asthma

How should Apo-Allopurinol be taken?

You should take your Apo-Allopurinol tablets 300mg once daily with a glass of water and after a meal to reduce risk of gastrointestinal side effects. The dose you take depends on your conditions, your age and your doctor’s recommendations. You should continue to take your Apo-Allopurinol tablets 300mg daily until your condition improves or for as long as your doctor recommends.

How long should you take Apo-Allopurinol?

You should continue to take your Apo-Allopurinol tablets 300mg daily until your condition improves or for as long as your doctor recommends.

Missed dose of Apo-Allopurinol

If you miss a dose of Apo-Allopurinol tablets 300mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Apo-Allopurinol be stored?

You should store your Apo-Allopurinol tablets 300mg below 25°C in a cool dry place.


All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
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