Premium Vision (Bilbery and Lutein)
Premium Vision 30 Capsules/Pack
Complete Eye Care
Bilberry & Lutein
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Premium Vision general information
What is Premium Vision used for?
Premium Vision capsules are a dietary supplement used to support general eye health, improve night vision and help prevent eye strain and eye damage. Premium Vision capsules are also used to help protect against age-related eye problems including cataract and age-related macular degeneration (AMD or ARMD), which is a major cause of vision loss amongst elderly people. The macular is the area of the retina at the back of the eye containing a high concentration of light sensitive cells that processes central vision, and damage to the macula results in loss of sharp central vision and can progress to severe vision loss. Risk factors for AMD include aging, smoking, exposure to strong sunlight and family history. Another possible supportive use for Premium Vision capsules is to help protect against diabetic retinopathy, which is damage to the retinal cells of the eye due to high levels of blood sugar from diabetes.
How does Premium Vision work?
Premium Vision capsules contain herbal extracts and vitamins that contribute to their protective effects on eye health, in particular age-related macular degeneration (AMD), in which oxidative damage by free radicles is thought to be involved in the pathogenesis of the disease. Antioxidant vitamins in Premium Vision capsules include vitamin C and vitamin E. Beta carotene and lutein are both carotenoids and are natural plant pigments that give fruit and vegetables their colour. They are also antioxidants that have an important role to play in human health by protecting against the damaging effect of free radicles1. Lutein is also of particular importance in eye health as it is found in high concentration in the macula of the eye and is known as a macular xanthophyll. Fruits and vegetables are a rich source of lutein and zeaxanthin, another macular pigment, and these pigments accumulate in the retina when consumed1 and they have been studied in terms of their protective effect on the macular, as both short-wavelength light filters (ultraviolet) and antioxidants. Increased levels of these pigments appear to correlate with decreased risk of AMD2. The Age Related Eye Disease Study (AREDS) is a major clinical study, sponsored by the National Eye Institute of the US that looked into a possible role of vitamin and mineral supplements in Age-related macular degeneration (AMD). The first study (AREDS 1) found that the AREDS formula containing vitamin C, vitamin E, beta carotene and zinc, which is an essential trace mineral and is concentrated in the retina of the eye, was effective in delaying the progression of AMD to more severe stages. Copper was added to balance the possible copper depleting effect of high zinc levels3, 4. The follow up study (AREDS 2) looked at the effect of adding high doses of the two macular xanthophylls lutein and zeaxanthin, to the AREDS formula. They found that lutein and zeaxanthin added to the AREDS formula without beta carotene reduced the risk of developing advanced AMD and that they were a safe and effective substitute for beta carotene, which was found to increase risk of lung cancer in smokers at high doses. This was an important consideration, particularly as smoking is a high risk factor for AMD and half the participants in the study were smokers at some point. The beneficial effects of taking vitamin and mineral supplements shown to prevent progression of AMD were found to be long lasting. Also, lutein and zeaxanthin were found to have a beneficial effect on cataract in a sub group of participants who had a low dietary intake 5, 6. Premium Vision capsules also contain an extract of the bilberry fruit (Vaccinium myrtillus), which is a rich source of anthocyanins, a natural pigment that give berries their red, blue and purple colour and have long been used as a traditional medicine. The bilberry has several health related properties including antioxidant and anti-inflammatory and there have been many studies indicating that bilberry has beneficial effects in relation to eye disorders and vision loss, suggesting there may be a role to play in helping to prevent progression of cataract, AMD and diabetic retinopathy, although further scientific evidence is required7, 8. Extract of grape seeds (vitis vinifera) is rich in procyanidins, which is one of the most effective natural antioxidants for removing free radicles and also has a wide range of biological functions, including protecting eyesight9 and studies in animals suggest that grape seed extract may help prevent progression of cataract10. Selenium and chromium are important trace elements that cannot be synthesised in the body and can only be obtained from the diet. The amount of selenium in the soil varies, and in many parts of the world is very low. Selenomethionine is an organic form of selenium that is easier for the body to utilise as a supplement. Selenium plays an important role in human health including protecting against oxidative stress and inflammation11. It is required for activity of an antioxidant enzyme glutathione peroxidase that is concentrated in the lens of the eye and some studies suggest that selenium may reduce risk of cataract formation12. Premium Vision capsules also contain Ginkgo biloba Leaf extract, which is also used as a traditional medicine. Ginkgo biloba Leaf extract is thought to have certain properties including increased blood flow, blocking platelet activation and preventing damage caused by free radicals. There is some evidence to suggest that Ginkgo biloba Leaf extract may help prevent progression of AMD, as vascular factors and oxidative damage are thought to be two potential mechanisms in its pathology, although additional studies are required13. The range of plant extracts, vitamins and trace elements in Premium vision capsules are thought to contribute to the beneficial effects on eye health by providing antioxidant protection against free radicle damage, as well as anti-inflammatory and other possible benefits.
What does Premium Vision contain?
Premium Vision capsules contain herbal extracts with the active ingredients Vaccinium myrtillus (Bilberry) (10g providing Anthocyanosides 25mg), Vitis vinifera Seed (Grape Seed) (Equivalent Procyanidins 25mg), Ginkgo biloba Leaf (Ginkgo) (500mg). They also contain the following vitamins and minerals: beta carotene (3mg), lutein (5mg), ascorbic acid (Vitamin C) (150mg), d-alpha-tocopheryl acid succinate (33mg equivalent Vitamin E 40IU), copper gluconate (3.57mg equivalent copper 500mcg), chromium yeast (5mg equivalent chromium 10mcg), L-Selenomethionine (125mcg equivalent selenium 50mcg), zinc gluconate (55mg equivalent zinc 7mg)
Premium Vision for age-related macular degeneration (AMD)
Premium Vision capsules contain herbal extracts and vitamins that contribute to their protective effects on eye health, in particular age-related macular degeneration (AMD), which is a major cause of vision loss amongst elderly people. The macular is the area of the retina at the back of the eye containing a high concentration of light sensitive cells that processes central vision, and damage to the macula results in loss of sharp central vision and can progress to severe vision loss. Risk factors for AMD include aging, smoking, exposure to strong sunlight and family history. Oxidative damage by free radicles and vascular factors are thought to be involved in the pathogenesis of the disease. Premium Vision capsules contain vitamin C and vitamin E, Beta carotene and lutein, which are powerful antioxidants, also zinc, which is an essential trace mineral and is concentrated in the retina of the eye. Lutein is also of particular importance in eye health as it is found in high concentration in the macula of the eye and is known as a macular xanthophyll. The Age Related Eye Disease Study (AREDS 1 and the follow up study AREDS 2), are major clinical studies, sponsored by the National Eye Institute of the US that looked into a possible role of vitamin and mineral supplements in AMD and found that vitamin C and vitamin E, Beta carotene zinc and lutein were effective in delaying the progression of AMD to more severe stages. Other factors thought to contribute to this include Ginkgo biloba Leaf, extract of the bilberry fruit (Vaccinium myrtillus). The range of plant extracts, vitamins and trace elements in Premium vision capsules are thought to contribute to the beneficial effects on eye health, particularly AMD by providing antioxidant protection against free radicle damage.
What are the side effects of Premium Vision?
Possible side effects when taking Premium Vision include, gastrointestinal upset like nausea, vomiting and diarrhoea, headache, dizziness.
When should Premium Vision not be used?
You should not use Premium Vision capsules if you:
- are allergic to Bilberry, Ginkgo and Lutein or any ingredients in Premium Vision
- are pregnant or are breastfeeding
- are taking medicines that interact with Premium Vision including anticoagulant like warfarin or antiplatelet drugs like clopidogrel, aspirin or ibuprofen, as grape seed extract, Ginkgo leaf extract and selenomethionine may increase risk of bleeding; statins as selenium may reduce effectiveness.
How should Premium Vision be taken?
You should take your Premium Vision one capsule daily with food or as advised by your healthcare professional. You should continue to take your Premium Vision capsules for as long as recommended by your healthcare professional.
How long should you take Premium Vision?
You should continue to take your Premium Vision capsules for as long as recommended by your healthcare professional.
Missed dose of Premium Vision
If you miss a dose of Premium Vision capsules take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.
How should Premium Vision be stored?
You should store your Premium Vision below 25°C in a cool dry place.
- Sommerburg O, J, Keunen J, Bird A, van Kuijk F J G M. Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br J Ophthalmol. 1998 Aug; 82(8): 907–910.
- Ahmed SS, Lott MN, Marcus DM. The macular xanthophylls. Surv Ophthalmol 2005 Mar-Apr;50(2):183-93.
- Age-Related Eye Disease Study Group. A randomized, placebo-controlled clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001; 119(10):1417–1436.
- Chew EY, Clemons TE, Agrón E, Sperduto RD, Sangiovanni JP, Kurinij N, Davis MD, Age-Related Eye Disease Study Research Group. Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35. Ophthalmology 2013 Aug;120(8):1604-11.
- AREDS2 Research Group, Chew EY, Clemons T, SanGiovanni JP, Danis R, Domalpally A, McBee W, Sperduto R, Ferris FL. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). Ophthalmology 2012 Nov;119(11):2282-9.
- Age-Related Eye Disease Study 2 (AREDS2) Research Group. Chew EY, Clemons TE, Sangiovanni JP, Danis RP, Ferris FL, Elman MJ, Antoszyk AN, Ruby AJ, Orth D, Bressler SB, Fish GE, Hubbard GB, Klein ML, Chandra SR, Blodi BA, Domalpally A, Friberg T, Wong WT, Rosenfeld PJ, Agrón E, Toth CA Bernstein PS, Sperduto RD. Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression:AREDS2 report No. 3. JAMA Ophthalmol 2014 Feb;132(2):142-9.
- Chu W, Cheung SCM, Lau RAW, Benzie IFF. Bilberry (Vaccinium myrtillus L.). In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 4.
- Ulbricht C, Basch E, Basch S, Bent S, Boon H, Burke D, Costa D, Falkson C, Giese N, Goble M, Hashmi S, Mukarjee S, Papaliodis G, Seamon E, Tanguay-Colucci S, Weissner W, Woods J. An evidence-based systematic review of bilberry (Vaccinium myrtillus) by the Natural Standard Research Collaboration. J Diet Suppl. 2009;6(2):162-200.
- Iglesias J, Pazos M, Torres JL, Medina I. Antioxidant mechanism of grape procyanidins in muscle tissues: redox interactions with endogenous ascorbic acid and α-tocopherol. Food Chem. 2012 Oct 15;134(4):1767-74. doi: 10.1016/j.foodchem.2012.03.072. Epub 2012 Mar 28.
- Durukan AH, Evereklioglu C, Hurmeric V, Kerimoglu H, Erdurman C, Bayraktar MZ, Mumcuoglu T. Ingestion of IH636 grape seed proanthocyanidin extract to prevent selenite-induced oxidative stress in experimental cataract. J Cataract Refract Surg 2006 Jun;32(6):1041-5.
- Rayman MP. Selenium and human health. Lancet. 2012 Mar 31;379(9822):1256-68.
- Christen WG, Glynn RJ, Gaziano JM, Darke AK, Crowley JJ, Goodman PJ, Lippman SM, Lad TE, Bearden JD, Goodman GE, Minasian LM, Thompson IM, Blanke CD, Klein EA. Age-related cataract in men in the selenium and vitamin e cancer prevention trial eye endpoints study: a randomized clinical trial. JAMA Ophthalmol 2015 Jan;133(1):17-24.
- Evans JR. Ginkgo biloba extract for age-related macular degeneration. Cochrane Database Syst Rev. 2013 Jan 31;1:CD001775.