Lopinavir and Ritonavir 200mg/50mg Tablets aka Lopimune
Lopimune general information
What is Lopimune used for?
Human Immunodeficiency Virus (HIV) is a type of virus known as a retrovirus. HIV is transmitted by direct contact with body fluids, such us from unprotected sex, breastfeeding, using contaminated syringes, or transfusion with contaminated blood. Infection with HIV damages the immune system, which is your body’s defence against invasion with harmful organisms. If left untreated, HIV infection can result in a condition called acquired immune deficiency syndrome (AIDS). Lopimune tablets 200/50mg are a fixed-dose combination medication used to treat HIV infection. Lopimune should be used in combination with other HIV-specific medicines that work by a different mechanism. Lopimune tablets help relieve acute symptoms of HIV infection and control the spread of the virus within the body to prevent the development of AIDS.
How does HIV cause AIDS?
HIV damages the immune system by attacking specific immune cells called CD4 cells. These are specialised white cells or T lymphocytes, also known as T helper cells, that interact with other immune cells like B lymphocytes and macrophages in fighting infection. As HIV continues to attack and destroy CD4 cells, the immune system becomes weakened and cannot work effectively.
Acute infection causes symptoms within 2-4 weeks that are like flu and include fever, headache. You may also develop a rash. At this stage, the virus is replicating rapidly, and the number of infectious virus particles in the body, known as the viral load, is very high. If the virus persists untreated in the body, replication continues, but it slows down. It is still highly contagious and is still causing damage to the immune system. This chronic stage of infection can last months, even years.
Eventually, the immune system is so damaged because too many CD4 cells have been destroyed, that it is unable to fight infection. This is the final and life-threatening lead stage of HIV infection known as acquired immune deficiency syndrome (AIDS). If you have been diagnosed with AIDS you will be severely immunocompromised, which means that you are highly susceptible to opportunistic infection. These are infections that would not usually be harmful and include Herpes Simplex Virus, Cytomegalovirus (CMV) that causes pneumonia and gastroenteritis, and Mycobacterium avium complex (MAC) that infects the lungs. Fungal infections of the mouth, lungs and brain can also cause serious problems. Kaposi’s sarcoma is a virus-related cancer that is associated with HIV infection. HIV is still very contagious at this stage, and AIDS has a poor prognosis, usually just a few years.
Antiretroviral therapy (ART)
The genetic material of retroviruses is RNA. The only way a retrovirus can multiply is to convert its RNA to DNA, using an enzyme produced by the virus called reverse transcriptase. Once a DNA copy has been made of the viral RNA, it can then get into (or integrate) the DNA of infected immune cells. This stage of the infection process depends on a viral enzyme known as integrase. Once integrated into the host immune cell DNA, the viral DNA can replicate, using the cellular equipment provided by the host cells.
Antiretroviral drugs are drugs that are only effective against retroviruses. Antiretroviral therapy (ART) is treatment using a combination of different classes of antiretroviral drugs that work by different mechanisms. Using a combination of drugs reduces the risk of the virus developing resistance to treatment. So if one medicine does not work, another one in the combination will.
Treatment for HIV is most effective if started as soon as symptoms appear and before the viral load increases rapidly. Although ART cannot cure the disease, it can reduce the viral load, reduce the risk of viral transmission, and improve quality of life.
How does Lopimune work?
Lopimune tablets 200/50mg contain lopinavir and ritonavir, which are both inhibitors of HIV protease and are used to treat infection with Human Immunodeficiency Virus (HIV). Lopimune tablets are only effective against retroviruses like HIV.
HIV produces a protease protein, which is an enzyme that breaks up large proteins into smaller protein units. HIV uses the host cell to produce a protein called the Gag-Pol polyprotein. This large precursor protein needs to be cut up into smaller units before HIV can develop into a mature, infectious virus particle. One of these protein units is the active viral protease enzyme. The final stage of the HIV replication cycle is the combination of its RNA with these small proteins, once the new virus particle is released from an infected cell. The mature virus, now called a virion (infectious virus particle), can infect more immune cells.
Lopinavir in Lopimune tablets 200/50mg is a protease inhibitor and works by blocking the action of the viral protease. This prevents the breakdown of the Gag-Pol polyprotein into smaller functional protein units, which results in the production of immature, non-infectious viral particles.
Ritonavir in Lopimune tablets 200/50mg is not included in this combination medication as a protease inhibitor. Ritonavir works by inhibiting the CYP3A-mediated metabolism (breakdown in the liver) of lopinavir. This increases the plasma levels of lopinavir so that it can be used at a lower dose.
The combined action of lopinavir and ritonavir in Lopimune tablets 200/50mg, when used in conjunction with other antiretroviral drugs, inhibits the production of active HIV. This reduces the amount of virus that can infect more cells.
What does Lopimune contain?
Lopimune tablets contains a combination of the active ingredients lopinavir (200mg) and ritonavir (50mg) that are used to treat infection with Human Immunodeficiency Virus (HIV) to control the spread of the virus within the body and prevent the development of AIDS (acquired immune deficiency syndrome).
What are the side effects of Lopimune?
Most medications have some side effects, but they are not experienced by everyone. Some side effects are commonly experienced when taking Lopimune tablets 200/50mg, but others are not so common, and you should discuss any problems or concerns with your primary care physician.
Common side effects when taking Lopimune include diarrhoea, nausea, vomiting, abdominal pain, reflux, bloating, pancreatitis, hepatitis, rash, respiratory infection, headache, dizziness, insomnia, anxiety, muscle and back pain, fatigue, erectile dysfunction, menstrual problems, hypertension, increased blood cholesterol and blood glucose disorders.
Other side effects include redistribution of body fat from the arms, legs and face to the abdominal region; inflammation reaction due to immune reconstitution syndrome, as the immune system recovers and fights infection caused by residual infection.
When should Lopimune not be used?
Have a talk with your primary healthcare physician before taking Lopimune tablets 200/50mg so that you have a full understanding of what this medicine is for and how to use it. There are some reasons for not taking a medication; these are called contraindications, and for Lopimune you should consider the following before taking Lopimune:
- Have you ever had an unusual reaction or an allergy when taking Lopimune?
- Are you pregnant or breastfeeding?
- Do you have a serious liver disease like hepatitis or cirrhosis?
- Do you have a have a heart condition including long QT syndrome, underlying structural heart disease, pre-existing conduction system abnormalities, ischemic heart disease or cardiomyopathies?
- Do you have the blood condition haemophilia, as Lopimune can cause increased bleeding?
- Do you have diabetes, as Lopimune can cause increased blood sugar?
What medications interact with Lopimune?
Some medicines interact with Lopimune tablets 200/50mg and may affect the way it works, or are affected by Lopimune or increase side effects; you should discuss possible interactions with your primary care physician. These may include other retrovirals like zidovudine and saquinavir, antiarrhythmics like amiodarone, anticancer agents like vincristine, the anticoagulant warfarin, anticonvulsants like carbamazepine, analgesics like fentanyl, digoxin for heart failure, the antidepressants trazodone and bupropion, anticonvulsants like phenytoin and carbamazepine, antifungals like ketoconazole, the antibiotics clarithromycin and rifampicin, benzodiazepines sedatives like midazolam, calcium channel blockers like nifedipine, corticosteroids like dexamethasone, the antipsychotic blonanserin, PDE5 inhibitors like sildenafil for erectile dysfunction, statin drugs atorvastatin like for high cholesterol, salmeterol for asthma, contraceptives like ethinyl estradiol, ergot drugs like ergotamine for migraine headaches, the herbal product St John's wort, cisapride for gastric reflux, the antipsychotic pimozide, colchicine for gout.
If other medications may interact with Lopimune, your doctor will discuss these with you.
How should Lopimune be taken and for how long?
You should take your Lopimune tablets 200/50mg swallowed whole with a glass of water with or without food, once or twice daily. The dose you take will depend on your condition, whether you have taken, or are currently taking other antiretroviral drugs and your doctor’s recommendation. Your dose may be increased or decreased depending on how well you respond and whether you have any reactions or side effects. For children, the dose should be calculated based on body weight or body surface area (BSA) and should not exceed the recommended adult dose. You should continue to take your Lopimune tablets 200/50mg regularly for as long as your doctor recommends as it helps control the HIV infection but does not cure it; do not stop taking your tablets even if you feel better without discussion with your doctor.
Missed dose of Lopimune
If you miss a dose of Lopimune tablets 200/50mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.
How should Lopimune be stored?
You should store your Lopimune tablets 200/50mg below 25°C in a cool dry place.
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Strone-100 Injection IM (Progesterone) 10 Ampoules/Pack
Strone-100 general information
What is Strone-100 used for?
Strone-100 injection is used to prevent miscarriage and help an early pregnancy to continue where there have been previous repeated unexplained miscarriages; or where the body has not produced enough progesterone to maintain the pregnancy due to a luteal phase defect. Strone-100 injection is also used to help with certain infertility treatments, including In-Vitro Ferilisation (IVF) or Gamete Intra-Fallopian Transfer (GIFT). In selected cases Strone-100 injection helps increase the chances that the fertilised egg will successfully implant into the endometrium. Another use for Strone-100 injection is to treat dysfunctional uterine bleeding, which is abnormal bleeding and includes heavy bleeding (menorrhagia), irregular bleeding, spotting mid-cycle, post-menopausal bleeding or no bleeding (amenorrhea). Uterine bleeding disorders are usually due to a hormonal imbalance between oestrogen and progesterone and Strone-100 injection is used to help restore this balance.
How does Strone-100 work?
Strone-100 injection contains progesterone, a hormone that is involved in regulating the normal menstrual cycle and is naturally produced by the ovaries during the second phase or luteal phase of the cycle. It acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase to prepare the endometrium for a pregnancy. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, if conception occurs; if not, levels of oestrogen and progesterone fall and the endometrium is shed (menstruation). Progesterone is produced by the corpus luteum in the ovary for the first few weeks of pregnancy (8-12 weeks) and once the fertilised egg has successfully implanted into the endometrium, progesterone is produced by the developing placenta to continue the pregnancy. Strone-100 injection helps maintain progesterone at levels that are sufficient for implantation to occur and for a pregnancy to continue to reduce the risk of a miscarriage. Strone-100 injection also helps maintain sufficient levels of progesterone for increasing the success of assisted fertility treatment for infertility; also progesterone in Strone-100 injection helps restore the balance between oestrogen and progesterone to correct uterine bleeding disorders.
What does Strone-100 contain?
Strone-100 injection contains the active ingredient progesterone a naturally produced hormone involved in the normal menstrual cycle and in maintaining a pregnancy. Each ampoule contains 100mg progesterone per 1mL in a medium chain triglyceride oil base with benzyl alcohol as preservative.
Treating threatened miscarriage with Strone-100
Strone-100 injection contains progesterone that is used to help prevent an early miscarriage and help the pregnancy to continue where there have been previous repeated unexplained miscarriages or miscarriage due to insufficient progesterone production to maintain the pregnancy due to a luteal phase defect. Progesterone is a natural hormone produced by the ovaries during the luteal phase of the menstrual cycle and acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, following conception. Progesterone is produced by the corpus luteum in the ovary for the first few weeks of pregnancy (8-12 weeks) and once the fertilised egg has successfully implanted into the endometrium, progesterone is produced by the developing placenta to continue the pregnancy. Strone-100 injection helps maintain progesterone levels needed for implantation and to continue the pregnancy to reduce the risk of a miscarriage.
Strone-100 for assisted fertility treatment
Strone-100 injection contains progesterone that is used to help increase the success of assisted fertility treatment for infertility. These include In-Vitro Ferilisation (IVF) or Gamete Intra-Fallopian Transfer (GIFT). Progesterone is a natural hormone produced by the ovaries during the luteal phase of the menstrual cycle and acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, following conception. Progesterone is produced by the corpus luteum in the ovary for the first few weeks of pregnancy (8-12 weeks) and then once the fertilised egg has successfully implanted into the endometrium, progesterone is produced by the developing placenta to continue the pregnancy. In selected cases Strone-100 injection helps increase the chances that the fertilised egg will successfully implant into the endometrium so that the pregnancy will continue.
Strone-100 for uterine bleeding disorders
Strone-100 injection contains progesterone that is used to treat dysfunctional uterine bleeding, which is abnormal bleeding and includes heavy bleeding (menorrhagia), irregular bleeding, spotting mid-cycle, post-menopausal bleeding or no bleeding (amenorrhea). Progesterone is a hormone involved in regulating the normal menstrual cycle and is naturally produced by the ovaries during the second or luteal phase of the cycle. It acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase to prepare the endometrium for a pregnancy. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, if conception occurs; if not, levels of oestrogen and progesterone fall and the endometrium is shed (menstruation). Uterine bleeding disorders are usually due to a hormonal imbalance between oestrogen and progesterone and Strone-100 injection is used to help restore this balance.
What are the side effects of Strone-100?
The most commonly reported side effects when taking Strone-100 include: menstrual changes (breakthrough bleeding, spotting, or missed periods) oedema (fluid retention), weight gain or loss dizziness, drowsiness, fever, headache, nausea, somnolence (sleepiness), skin irritation at the site of injection, breast changes. More severe side effects include jaundice.
When should Strone-100 not be used?
You should not use Strone-100 if you:
- are allergic to progesterone or other progestins or any ingredients in Strone-100
- have ever had an incomplete or missed abortion/miscarriage
- have a past or family history of carcinoma of the breast, endometrial carcinoma
- a history of thrombosis (blood clots) or stroke
- abnormal genital bleeding of unknown cause
- have liver disease
- are taking medicines that interact with Strone-100, including bromocriptine (for menstrual problems), the immunosuppressant cyclosporine.
How should Strone-100 be used?
You will be given Strone-100 by intra-muscular injection into the buttock, by your nurse or doctor. The dose you are given and how frequently will depend on what you are being treated for and your doctor’s recommendation. For a threatened miscarriage you will be given one injection immediately, followed by daily injections for 7-10 days. To prevent a miscarriage or to assist with infertility treatment you will be given an injection usually twice weekly from around day 9 up to 12-14 weeks of pregnancy. For uterine bleeding disorders, you will be given an injection daily for 5-10 days until around two days before your period is due.
How long should you take Strone-100?
The dose you are given and how frequently will depend on what you are being treated for and your doctor’s recommendation.
Missed dose of Strone-100
If you have missed a dose of Strone-100 contact your nurse or doctor as soon as you remember.
How should Strone-100 be stored?
You should store your Strone-100 below 25°C in a cool dry place and protect from light.
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Kamagra (Sildenafil 100mg) Chewable Tablets (Combipack)
Kamagra general information
What is Kamagra used for?
Erectile dysfunction, commonly called impotence, is the inability to achieve or maintain a hard erect penis for satisfactory sexual activity. It is a common problem and affects many men, particularly with increasing age. Kamagra Chewable Tablets 100mg are used to treat erectile dysfunction in men to resolve impotence due to insufficient blood flow into the penis.
Erectile dysfunction
When aroused, blood vessels in the penis relax and widen, which increases blood flow into the spongy erectile tissue. This allows an erection to develop and is the natural response to sexual stimulation. Any disruption to the normal process can cause erectile dysfunction.
Reasons for impotence may be physical or emotional. Emotional factors that influence impotence include stress, anxiety, trauma, childhood abuse, relationship problems. Lifestyle factors like smoking, drinking alcohol, narcotic drugs like morphine or opium also affect sexual function. Other causes include hormone imbalance, nerve damage, health conditions like diabetes and high blood pressure, and some medications like antidepressants and antipsychotics.
The natural process of sexual stimulation involves many of your senses, including touch, smell, sight, and hearing. These activate areas of the brain to send out nerve signals that initiate arousal. Once aroused, a series of biochemical reactions are activated, resulting in the relaxation of blood vessels in the penis and increasing blood flow needed for an erection. When arousal and sexual activity are complete, another series of biochemical reactions trigger the end of an erection.
Kamagra Chewable Tablets 100mg works with the natural processes to extend erection time by increasing blood flow in the penis. However, Kamagra Chewable tabs 100mg will only work if you are sexually aroused.
How does Kamagra work?
Kamagra Chewable Tablets 100mg contain sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction or impotence in men. Sildenafil in Kamagra Chewable tabs 100mg acts on the erectile tissue of the penis to increase blood flow into the penis, which is needed to cause an erection.
During sexual stimulation, nitric oxide is released in the erectile tissue of the penis, which activates the enzyme guanylate cyclase. This enzyme increases levels of a chemical called cyclic guanosine monophosphate (cGMP), which relaxes the blood vessels in the penis and allows blood to fill the spongy erectile tissues to cause an erection. Another enzyme called phosphodiesterase type 5 (PDE5) breaks down cGMP preventing blood flow into the penis, which causes loss of an erection. Sildenafil in Kamagra-100 chewable tabs inhibits the action of PDE5. This resolves erectile dysfunction by allowing the natural process of sexual stimulation to activate the cGMP mechanism for achieving and maintaining an erection. Kamagra Chewable tabs 100mg are faster acting than the tablet form as sildenafil is absorbed into the blood more rapidly, being effective within 20-30 minutes and lasting for up to four hours.
What does Kamagra contain?
Kamagra Chewable Tablets 100mg contain the active ingredient sildenafil citrate (100mg), a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction in men.
What are the side effects of Kamagra?
Most medications have some side effects, but they are not experienced by everyone. Some side effects are commonly experienced when taking Kamagra Chewable Tablets 100mg, but others are not so common, and you should discuss any problems or concerns with your primary care physician.
Common side effects when taking Kamagra include headache, dizziness, flushing, indigestion, nausea, nasal congestion, visual disturbances, blurred vision, and colour distortion.
When should Kamagra not be used?
Have a talk with your primary healthcare physician before taking Kamagra Chewable Tablets 100mg so that you have a full understanding of what this medicine is for and how to use it. There are some reasons for not taking a medication; these are called contraindications, and for Kamagra you should consider the following before taking Kamagra:
- Have you ever had an unusual reaction or an allergy when taking Kamagra?
- Are you pregnant or breastfeeding?
- Do you have any problems with your liver?
- Do you have a condition where sexual intercourse inadvisable due to cardiovascular or heart problems or you have had a heart attack or stroke in the last six months?
- Do you have abnormally high or low blood pressure?
- Do you have an eye disease like non-arteritic anterior ischaemic optic neuropathy (NAION), which causes loss of vision or if you have retinitis pigmentosa?
- are taking any nitrate medication, such as nitroglycerin for angina, as it may lead to a severe drop in blood pressure?
What medications interact with Kamagra?
Some medicines interact with Kamagra Chewable Tablets 100mg and may affect the way it works, or are affected by Kamagra or increase side effects; you should discuss possible interactions with your primary care physician. These may include cimetidine for treating ulcers, antibiotics like erythromycin and rifampicin, verapamil or diltiazem for high blood pressure, ritonavir or saquinavir for HIV, itraconazole or ketoconazole for fungal infections, alpha-blockers like doxazosin for high blood pressure.
If other medications may interact with Kamagra, your doctor will discuss these with you.
How should Kamagra be taken and for how long?
You should take your Kamagra Chewable Tablets 100mg approximately one hour before sexual activity (between 0.5 and 4 hours) and without food. You should chew a single tab whole before swallowing. If you have a large meal before taking your Kamagra Chewable tabs it may take longer to work. Kamagra Chewable tabs are effective within 20-30 minutes and last for four to six hours. You should take no more than one tablet per day and only if you plan to have sex.
Missed dose of Kamagra
You should only take Kamagra Chewable tabs 100mg when you plan to have sex; it is not intended as a regular medication.
How should Kamagra be stored?
You should store your Kamagra Chewable tabs 100mg below 25°C in a cool dry place.
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Pimafucort (Hydrocortisone/Natamycin/Neomycin) Ointment
Pimafucort general information
What is Pimafucort used for?
Pimafucort Ointment is used for the short-term treatment of superficial skin conditions (dermatoses), that have become or are at risk of becoming infected with a bacterial or fungal infection. These skin conditions include dermatitis (inflammation of the skin), seborrhoeic dermatitis (caused by over active sebaceous glands), eczema also called atopic dermatitis as there is a predisposition due to an inherited atopic tendency, lichen simplex a form of dermatitis made worse by constant itching and scratching. Also, psoriasis, autoimmune skin condition characterised by a chronic scaly rash. Pimafucort Ointment helps relieve symptoms like itching, redness, dryness, crusting, scaling and discomfort common to many skin conditions, particularly where there is inflammation and where there is also the added complication of a bacterial and/or fungal (usually candida) infection.
How does Pimafucort work?
Pimafucort Ointment contains a combination of the corticosteroid hydrocortisone, the antibiotic neomycin, and the antifungal natamycin, that work together to treat inflammatory and infected skin conditions. Hydrocortisone in Pimafucort Ointment is a potent anti-inflammatory with anti-pruritic properties (anti-itching) and works by blocking the action of phospholipase A2, the first enzyme involved in the synthesis of prostaglandins and leukotrienes, which are hormone-like substances involved in the inflammatory process; also cyclooxygenase (COX 1 and COX 2), the enzymes specifically involved in prostaglandin production. Blocking the production of inflammatory chemicals prevents the swelling and redness characteristic of inflammation and the itching and rash formation that can happen as a result of inflammation. Hydrocortisone in Pimafucort Ointment also causes vasoconstriction (blood vessels contract), which constricts blood vessels that have become dilated (widened) and leaky, allowing other inflammatory cells into the skin to escalate the inflammatory response. Neomycin in Pimafucort Ointment is a broad-spectrum antibiotic that is commonly used in creams and ointments and is effective against a wide range of bacteria that cause skin infections. Neomycin in Pimafucort Ointment works by blocking the synthesis of essential proteins needed for the bacteria to survive and replicate, which kills the bacteria and prevents spread of infection. Natamycin in Pimafucort Ointment is an antifungal that is particularly active against yeast infections caused by the yeast candida. It works by binding to ergosterol, an important component of the fungal cell membrane that is not found in animal cells. Natamycin in Pimafucort Ointment weakens the fungal cell membrane, causing the cell contents to leak out, which kills the fungus. Pimafucort Ointment helps relieve symptoms of inflammation and prevents spread of bacterial and fungal infections of the skin.
What does Pimafucort contain?
Pimafucort Ointment contains a combination of three active ingredients: the corticosteroid hydrocortisone (10mg/g), the antibiotic neomycin (3.5mg/g), and the antifungal natamycin (10mg/g), that work together to treat inflammatory and infected skin conditions. It also contains polyethylene oleogel (liquid paraffin with 5% w/w polyethylene).
Treating infected skin conditions with Pimafucort
Pimafucort Ointment contains a combination of the corticosteroid hydrocortisone, the antibiotic neomycin, and the antifungal natamycin, that are used to treat superficial skin conditions, that have become or are at risk of becoming infected with a bacterial or fungal infection. These skin conditions include dermatitis, eczema, seborrhoeic dermatitis, lichen simplex (a form of dermatitis) and psoriasis, an autoimmune skin condition characterised by a chronic scaly rash. Hydrocortisone in Pimafucort Ointment is a potent anti-inflammatory with anti-pruritic properties (anti-itching) and works by blocking the production of inflammatory mediators like prostaglandins that cause swelling and redness characteristic of inflammation and the itching and rash formation that can happen as a result of inflammation. Hydrocortisone in Pimafucort Ointment also causes leaky blood vessels to constrict, preventing leakage of inflammatory cells at the site of inflammation. Neomycin in Pimafucort Ointment is a broad-spectrum antibiotic effective against a wide range of bacteria that cause skin infections and works by blocking the synthesis of essential proteins needed for the bacteria to survive and replicate, which kills the bacteria and prevents spread of infection. Natamycin in Pimafucort Ointment is an antifungal that works by binding to ergosterol, an important component of the fungal cell membrane which weakens the fungal cell membrane, causing the cell contents to leak out, which kills the fungus. Pimafucort Ointment helps relieve symptoms of inflammation and prevents spread of bacterial and fungal infections of the skin.
What are the side effects of Pimafucort?
The most commonly reported side effects when taking Pimafucort Ointment include temporary aggravation of the skin lesion, worsening of the skin condition known as rebound effect, skin irritation due to contact allergy to neomycin, thinning or discolouration of the skin, delayed wound healing, discolouration or depigmentation of the skin, reddening of the skin, skin rash, increased hair growth.
When should Pimafucort not be used?
You should not use Pimafucort Ointment if you:
- are allergic to hydrocortisone, neomycin, natamycin, or any ingredients in Pimafucort
- have had side effects to other corticosteroids like dermatitis around the mouth or stretch marks
- are pregnant or are breastfeeding, without discussion with your doctor
- have a primary bacterial, fungal, viral or parasitic skin infection
- have ulcers on the skin, wounds or burns
How should Pimafucort be used?
You should apply a small amount of your Pimafucort Ointment to the affected area of skin 2-4 times daily and gently rub into the skin. Wash your hands before and after use and avoid contact with the eyes. Do not use Pimafucort Ointment on the eye-lids as this can increase risk of glaucoma or cataracts. You should continue to use your Pimafucort Ointment for as long as recommended by your doctor but should not exceed 14 days.
Pimafucort Ointment should be used for treatment of chronic skin disorders with scaly, dry or fissured skin lesions, and for seborrhoeic dermatitis.
Pimafucort Cream should be used for treatment of acute and subacute skin disorders, particulary if the skin condition is in a hairy area of skin or in skin folds.
How long should you use Pimafucort?
You should continue to use your Pimafucort Ointment for as long as recommended by your doctor but should not exceed 14 days.
Missed dose of Pimafucort
If you miss a dose of Pimafucort Ointment apply it as soon as you remember, unless it is time to apply the next dose, then skip the missed dose. Do not apply a double dose.
How should Pimafucort be stored?
You should store your Pimafucort Ointment below 25°C in a cool dry place.
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Strone-200 Injection IM (Progesterone) 10 Ampoules/Pack
Strone-200 general information
What is Strone-200 used for?
Strone-200 injection is used to prevent miscarriage and help an early pregnancy to continue where there have been previous repeated unexplained miscarriages; or where the body has not produced enough progesterone to maintain the pregnancy due to a luteal phase defect. Strone-200 injection is also used to help with certain infertility treatments, including In-Vitro Ferilisation (IVF) or Gamete Intra-Fallopian Transfer (GIFT). In selected cases Strone-200 injection helps increase the chances that the fertilised egg will successfully implant into the endometrium. Another use for Strone-200 injection is to treat dysfunctional uterine bleeding, which is abnormal bleeding and includes heavy bleeding (menorrhagia), irregular bleeding, spotting mid-cycle, post-menopausal bleeding or no bleeding (amenorrhea). Uterine bleeding disorders are usually due to a hormonal imbalance between oestrogen and progesterone and Strone-200 injection is used to help restore this balance.
How does Strone-200 work?
Strone-200 injection contains progesterone, a hormone that is involved in regulating the normal menstrual cycle and is naturally produced by the ovaries during the second phase or luteal phase of the cycle. It acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase to prepare the endometrium for a pregnancy. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, if conception occurs; if not, levels of oestrogen and progesterone fall and the endometrium is shed (menstruation). Progesterone is produced by the corpus luteum in the ovary for the first few weeks of pregnancy (8-12 weeks) and once the fertilised egg has successfully implanted into the endometrium, progesterone is produced by the developing placenta to continue the pregnancy. Strone-200 injection helps maintain progesterone at levels that are sufficient for implantation to occur and for a pregnancy to continue to reduce the risk of a miscarriage. Strone-200 injection also helps maintain sufficient levels of progesterone for increasing the success of assisted fertility treatment for infertility; also progesterone in Strone-200 injection helps restore the balance between oestrogen and progesterone to correct uterine bleeding disorders.
What does Strone-200 contain?
Strone-200 injection contains the active ingredient progesterone a naturally produced hormone involved in the normal menstrual cycle and in maintaining a pregnancy. Each ampoule contains 200mg progesterone per 2mL in a medium chain triglyceride oil base with benzyl alcohol as preservative. ie it is Progesterone 100mg/ml but is a 2ml vial containing 200mg
Treating threatened miscarriage with Strone-200
Strone-200 injection contains progesterone that is used to help prevent an early miscarriage and help the pregnancy to continue where there have been previous repeated unexplained miscarriages or miscarriage due to insufficient progesterone production to maintain the pregnancy due to a luteal phase defect. Progesterone is a natural hormone produced by the ovaries during the luteal phase of the menstrual cycle and acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, following conception. Progesterone is produced by the corpus luteum in the ovary for the first few weeks of pregnancy (8-12 weeks) and once the fertilised egg has successfully implanted into the endometrium, progesterone is produced by the developing placenta to continue the pregnancy. Strone-200 injection helps maintain progesterone levels needed for implantation and to continue the pregnancy to reduce the risk of a miscarriage.
Strone-200 for assisted fertility treatment
Strone-200 injection contains progesterone that is used to help increase the success of assisted fertility treatment for infertility. These include In-Vitro Ferilisation (IVF) or Gamete Intra-Fallopian Transfer (GIFT). Progesterone is a natural hormone produced by the ovaries during the luteal phase of the menstrual cycle and acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, following conception. Progesterone is produced by the corpus luteum in the ovary for the first few weeks of pregnancy (8-12 weeks) and then once the fertilised egg has successfully implanted into the endometrium, progesterone is produced by the developing placenta to continue the pregnancy. In selected cases Strone-200 injection helps increase the chances that the fertilised egg will successfully implant into the endometrium so that the pregnancy will continue.
Strone-200 for uterine bleeding disorders
Strone-200 injection contains progesterone that is used to treat dysfunctional uterine bleeding, which is abnormal bleeding and includes heavy bleeding (menorrhagia), irregular bleeding, spotting mid-cycle, post-menopausal bleeding or no bleeding (amenorrhea). Progesterone is a hormone involved in regulating the normal menstrual cycle and is naturally produced by the ovaries during the second or luteal phase of the cycle. It acts on the endometrium (lining of the uterus) converting the proliferating phase to the secretory phase to prepare the endometrium for a pregnancy. This causes the endometrium, which has thickened in response to oestrogen during the first half of the cycle, to stop growing and start secreting hormones and other proteins needed to maintain a pregnancy, if conception occurs; if not, levels of oestrogen and progesterone fall and the endometrium is shed (menstruation). Uterine bleeding disorders are usually due to a hormonal imbalance between oestrogen and progesterone and Strone-200 injection is used to help restore this balance.
What are the side effects of Strone-200?
The most commonly reported side effects when taking Strone-200 include: menstrual changes (breakthrough bleeding, spotting, or missed periods) oedema (fluid retention), weight gain or loss dizziness, drowsiness, fever, headache, nausea, somnolence (sleepiness), skin irritation at the site of injection, breast changes. More severe side effects include jaundice.
When should Strone-200 not be used?
You should not use Strone-200 if you:
- are allergic to progesterone or other progestins or any ingredients in Strone-200
- have ever had an incomplete or missed abortion/miscarriage
- have a past or family history of carcinoma of the breast, endometrial carcinoma
- a history of thrombosis (blood clots) or stroke
- abnormal genital bleeding of unknown cause
- have liver disease
- are taking medicines that interact with Strone-200, including bromocriptine (for menstrual problems), the immunosuppressant cyclosporine.
How should Strone-200 be used?
You will be given Strone-200 by intra-muscular injection into the buttock, by your nurse or doctor. The dose you are given and how frequently will depend on what you are being treated for and your doctor’s recommendation. For a threatened miscarriage you will be given one injection immediately, followed by daily injections for 7-10 days. To prevent a miscarriage or to assist with infertility treatment you will be given an injection usually twice weekly from around day 9 up to 12-14 weeks of pregnancy. For uterine bleeding disorders, you will be given an injection daily for 5-10 days until around two days before your period is due.
How long should you take Strone-200?
The dose you are given and how frequently will depend on what you are being treated for and your doctor’s recommendation.
Missed dose of Strone-200
If you have missed a dose of Strone-200 contact your nurse or doctor as soon as you remember.
How should Strone-200 be stored?
You should store your Strone-200 below 25°C in a cool dry place and protect from light.
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