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Outside UK/USA: 1 877 271 6591
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Non-Steroidal Anti-Inflammatory
Our Non-Steroidal Anti-Inflammatory class of Joint and Bone Health medications are used to help reduce pain and inflammation of arthritis in joints due to all forms of arthritis.

Use the search feature to quickly find the product you are looking for by entering either the active ingredient, e.g. celecoxib; or the product name e.g. Celebrex.

...Read more
Our Non-Steroidal Anti-Inflammatory class of Joint and Bone Health medications are used to help reduce pain and inflammation of arthritis in joints due to all forms of arthritis.

Use the search feature to quickly find the product you are looking for by entering either the active ingredient, e.g. celecoxib; or the product name e.g. Celebrex.

...Read more

APO-Diclo (Diclofenac 75mg)
APO-Diclo (Diclofenac 75mg)

Diclofenac
Also known as Voltaren
From $0.15 per Tablet
APO-Diclo SR 100mg (diclofenac sodium)
APO-Diclo SR 100mg (diclofenac sodium)

diclofenac
Also known as Voltaren Slow Release
From $0.20 per Tablet
Brufen SR 800mg (Ibuprofen)
Brufen SR 800mg (Ibuprofen)
Ibuprofen
From $0.87 per Tablet
Celebrex 100mg
Celebrex 100mg
Celecoxib
From $0.72 per Capsule
Cobix 200mg (Celecoxib)
Cobix 200mg (Celecoxib)

Celecoxib
Also known as Celebrex
From $0.97 per Capsule
Celecoxib 200mg Pfizer
Celecoxib 200mg Pfizer

Celecoxib
Also known as Celebrex (and made by the same manufacturer)
From $1.43 per Capsule
Indocap (Indomethacin) 25mg
Indocap (Indomethacin) 25mg

Indomethacin
Also known as Indocid
From $0.40 per Capsule
Indocap SR (Indomethacin 75mg)
Indocap SR (Indomethacin 75mg)

Indomethacin
Also known as Indocid
From $0.88 per Capsule
Melorex (Meloxicam 7.5mg)
Melorex (Meloxicam 7.5mg)
Meloxicam
Also known as Mobic or Metacam
From $1.20 per Tablet
Melorex (Meloxicam 15mg)
Melorex (Meloxicam 15mg)
Meloxicam
Also known as Mobic or Metacam
From $1.50 per Tablet
Mobic 7.5mg (Meloxicam)
Mobic 7.5mg (Meloxicam)
Meloxicam
From $1.90 per Tablet
Noflam 500 (Naproxen)
Noflam 500 (Naproxen)
Naproxen 500mg
Also known as Naprosyn
From $0.27 per Gram
Naprosyn SR (Naproxen 750mg)
Naprosyn SR (Naproxen 750mg)
Naproxen
From $0.59 per Tablet
Naprosyn SR (Naproxen 1000mg) 28
Naprosyn SR (Naproxen 1000mg) 28
Naproxen
From $0.87 per Tablet
Oruvail SR (Ketoprofen 200mg)
Oruvail SR (Ketoprofen 200mg)
Ketoprofen
Once daily slow release formula
From $1.50 per Capsule
Voltaren D (Diclofenac 50mg)
Voltaren D (Diclofenac 50mg)
Diclofenac
Tablets may swallowed whole or dispersed in water first.
From $0.85 per Tablet
Voltaren Emulgel
Voltaren Emulgel
Diclofenac
From $0.31 per Gram

What is inflammation?

Inflammation is a normal reaction to protect the body from harmful pathogens or irritants, such as chemicals, and to promote healing of damaged tissues, as in arthritis. It is a complex process of cellular interactions of the immune system that is mediated by chemicals produced at the site of tissue damage, infection or trauma.

The process of inflammation includes the widening and increased permeability of small blood vessels, exudation of fluid into and migration of immune cells like macrophages and neutrophils into the tissues where damage, infection or irritation has occurred. The fluid causes swelling and the cells produce inflammatory chemicals like prostaglandins, interleukins and leukotrienes. These chemicals attract more inflammatory cells to help with wound healing and disposing of harmful pathogens but they also magnify the inflammatory response. In doing their job, some of these inflammatory mediators can also cause pain, swelling, fever and redness. If the inflammatory process continues beyond protecting and healing, it becomes chronic and can end up damaging normal tissues.

Inflammation and prostaglandins

Nonsteroidal anti-inflammatory drugs (NSAID) inhibit cyclooxygenase (COX), an enzyme involved in the synthesis of prostaglandins like PGE2, which have important functions throughout the body but are also potent inflammatory mediators and cause pain, swelling and other symptoms of inflammation. They are called nonsteroidal as corticosteroids are also used to treat inflammation but target a different enzyme in the pathway of prostaglandin synthesis.

There are two known COX enzymes, COX-1, COX-2 and there is also a variant of COX-1, known as COX-3, which is found mainly in the brain. COX-1 is present in most cells and plays an important role in many normal cell functions, including aggregation of blood platelets, which controls bleeding; protection of the stomach lining or mucosa by promoting cell growth; also in maintaining normal kidney function by regulating blood flow. COX-2 is only produced by inflammatory cells, and is induced during the inflammatory process, although it is also found in very small amounts in some tissues.

Oral anti- inflammatory drugs

Oral nonsteroidal anti-inflammatory drugs (NSAID) target inflammation systemically, wherever it occurs throughout the body and can be used for short-term or long-term treatment of inflammatory joint diseases like arthritis, to help relieve pain and improve mobility in affected joints.

Meloxicam and celecoxib are specific COX-2 inhibitors and have no inhibitory action against COX-1, which makes them more effective for pain and inflammation, without the gastrointestinal or kidney side effects associated with COX-1 inhibition.

Topical anti-inflammatory drugs

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits primarily COX-2 but also has some inhibitory effect on COX-1 and is, therefore, more specific as an anti-inflammatory than other non-specific NSAIDs like Ibuprofen. As a topical treatment for arthritis, diclofenac is absorbed through the skin and acts directly on the soft tissues surrounding joints to relieve pain and inflammation due to sprains and strains. It also acts within superficial arthritic joints, such as the hands, wrists, elbows, knees, ankles or feet, to reduce inflammation due to osteoarthritis and relieve symptoms like pain and swelling in the joints.
...Read more

What is inflammation?

Inflammation is a normal reaction to protect the body from harmful pathogens or irritants, such as chemicals, and to promote healing of damaged tissues, as in arthritis. It is a complex process of cellular interactions of the immune system that is mediated by chemicals produced at the site of tissue damage, infection or trauma.

The process of inflammation includes the widening and increased permeability of small blood vessels, exudation of fluid into and migration of immune cells like macrophages and neutrophils into the tissues where damage, infection or irritation has occurred. The fluid causes swelling and the cells produce inflammatory chemicals like prostaglandins, interleukins and leukotrienes. These chemicals attract more inflammatory cells to help with wound healing and disposing of harmful pathogens but they also magnify the inflammatory response. In doing their job, some of these inflammatory mediators can also cause pain, swelling, fever and redness. If the inflammatory process continues beyond protecting and healing, it becomes chronic and can end up damaging normal tissues.

Inflammation and prostaglandins

Nonsteroidal anti-inflammatory drugs (NSAID) inhibit cyclooxygenase (COX), an enzyme involved in the synthesis of prostaglandins like PGE2, which have important functions throughout the body but are also potent inflammatory mediators and cause pain, swelling and other symptoms of inflammation. They are called nonsteroidal as corticosteroids are also used to treat inflammation but target a different enzyme in the pathway of prostaglandin synthesis.

There are two known COX enzymes, COX-1, COX-2 and there is also a variant of COX-1, known as COX-3, which is found mainly in the brain. COX-1 is present in most cells and plays an important role in many normal cell functions, including aggregation of blood platelets, which controls bleeding; protection of the stomach lining or mucosa by promoting cell growth; also in maintaining normal kidney function by regulating blood flow. COX-2 is only produced by inflammatory cells, and is induced during the inflammatory process, although it is also found in very small amounts in some tissues.

Oral anti- inflammatory drugs

Oral nonsteroidal anti-inflammatory drugs (NSAID) target inflammation systemically, wherever it occurs throughout the body and can be used for short-term or long-term treatment of inflammatory joint diseases like arthritis, to help relieve pain and improve mobility in affected joints.

Meloxicam and celecoxib are specific COX-2 inhibitors and have no inhibitory action against COX-1, which makes them more effective for pain and inflammation, without the gastrointestinal or kidney side effects associated with COX-1 inhibition.

Topical anti-inflammatory drugs

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits primarily COX-2 but also has some inhibitory effect on COX-1 and is, therefore, more specific as an anti-inflammatory than other non-specific NSAIDs like Ibuprofen. As a topical treatment for arthritis, diclofenac is absorbed through the skin and acts directly on the soft tissues surrounding joints to relieve pain and inflammation due to sprains and strains. It also acts within superficial arthritic joints, such as the hands, wrists, elbows, knees, ankles or feet, to reduce inflammation due to osteoarthritis and relieve symptoms like pain and swelling in the joints.
...Read more

All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
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