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Bowel

Our Bowel class of Digestive medications used to treat of disorders the bowel (lower GI tract) like Inflammatory bowel disease and Irritable bowel syndrome, caused by inflammation, immune system dysfunction, stress, muscle spasm and infection; also constipation due to dysmobility of the intestine.

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. mesalazine or the product name, e.g. Asacol.

Inflammatory bowel diseases

Inflammatory bowel disease (IBD) is a group of disorders caused by chronic inflammation of the intestines. The two most common forms of IBD are Crohn's Disease, which can affect any part of the upper or lower GI tract, and ulcerative colitis that affects only the large intestine or colon and rectum. Both diseases are thought to be autoimmune diseases due to an over-reactive immune system, when the immune system attacks self, in this case, intestinal tissue. Symptoms vary from mild to severe when inflammation flares up with symptoms including, abdominal pain and cramping, rectal bleeding, diarrhoea and vomiting. Medications used for treating IBD to relieve symptoms include:
  • Anti-inflammatory drugs like Mesalazine that inhibit the cyclo-oxygenase enzyme (COX) and block the production of inflammatory chemicals like prostaglandins and leukotrienes, which also inhibits the migration of inflammatory cells like macrophages into intestine wall.

  • Immunomodifiers like sulphasalazine, which have anti-inflammatory, immunomodulatory and immunosuppressive effects and work by several different mechanisms, including, inhibiting production of inflammatory chemicals like prostaglandins and leukotrienes, which are also involved in immune reactions, influencing white cell function and inhibiting antibody production.

  • Corticosteroids like budesonide, which are also anti-inflammatory but work by a different mechanism, binding to a glucocorticosteroid receptor in the intestinal cells and inhibiting the production of inflammatory cytokines and cytokine-mediated immune responses.

Irritable bowel syndrome

Irritable bowel syndrome (IBS) covers a range of functional bowel disorders and includes conditions like chronic irritable colon (spastic colon), spastic constipation, spastic colitis and nervous diarrhoea. IBS has no specific cause but may be triggered by several factors, including food sensitivity, stress and infection. Symptoms are caused by spasm of the intestinal muscle as it squeezes food through the intestine and include abdominal pain and cramps, diarrhoea (with or without alternating constipation) and flatulence (wind). Medications used for treating IBD include:
  • Antispasmodics like mebeverine and propantheline that are both anticholinergic and work primarily by blocking the action of the neurotransmitter acetylcholine that is involved in regulating intestinal smooth muscle contraction. This action allows the smooth muscle to relax, reducing muscle spasm.

  • Serotonin agonists like tegaserod that also regulate intestinal smooth muscle contraction by binding to specific serotonin receptors found only in the nerve cells of the GI tract and this helps restore normal bowel motility; it also helps reduce sensitivity to pain and discomfort caused by symptoms of IBS.

Constipation

Chronic constipation may be a symptom of several GI disorders and is characterised by hard stools that are difficult to pass and infrequent bowel movements. Laxatives like lactulose help soften the stools by changing the osmotic pressure in the colon and allowing water to be drawn into the colon, which also increases bowel motility and makes the stools easier to pass.
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"Thank you. I received my first shipment last week and I am very happy with the whole ordering experience and results."
Katherine FL, USA • November 2024
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Nancy WV, USA • October 2020
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Susan TX, USA • February 2020
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Victoria CO, USA • February 2021
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Lucas VA, USA • October 2023
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Mike OK, USA • February 2024
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"Staff is very responsive and I do not mind the shipping times! Very affordable and has helped my quality of life a lot. Had one hiccup and staff were QUICK with assisting me to ensure I get what I paid for! Have been a customer since 2022."
Emily OH, USA • February 2024
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""Easy to order ... looking forward to becoming a return account holder.""
Martyne OR, USA • February 2021
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""I have been using Inhouse since 2015. I have not had 1 bad experience. I continue to be impressed with their high standards & quality medications. I highly recommend them. It is worth mentioning that as the products come from outside the USA, it does take 2-4 weeks for delivery. Not an unreasonable amount of time . A person just needs to be patient & order early.""
Sandra MI, USA • February 2021
 

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