United States / USD Country & Currency
Country
United States
Currency
US Dollars
Save
Country
Australia
Gibraltar
Hong Kong
Malta
Northern Ireland
Puerto Rico
Scotland
Singapore
Switzerland
United Kingdom
United States
Currency
US Dollars
GB Pounds
AU Dollars
Euro
Explore our range Categories
Ask us a question 877-271-6591 or 800-868-9064

Shipping delays due to Covid-19 Virus

Please fill the form to receive updates when we can ship your order.

Estrogens

Our Estrogens class of products contains transgender hormone pills, particularly various forms of the female hormone estrogen such as Estrofem and Progynova. Use these in a feminizing regimen for transgender hormone therapy during a gender reassignment programme.

About estrogen

Estrogens are produced by the ovaries along with progesterone at certain stages of the menstrual cycle and their production is under control of follicle stimulating hormone (FSH) and luteunising hormone (LH) produced by the pituitary gland, which are in turn under the control of gonadotrophin releasing hormones produced by the hypothalamus in the brain.  

Estrogen is the main female hormone that stimulates development of female secondary sexual characteristics like breast development, body shape and regulating the menstrual cycle.  Therefore, estrogen is used as the main component of trangender hormone therapy for male to female transexuals while at the same time overriding the effects of testosterone.  

Different forms of estrogen

Estrogen exists in several forms and with different potencies:

  • Estradiol, specifically 17-beta-estradiol or E2, is the major and most active form of natural estrogen in the body produced by the ovaries and is responsible for the main actions of estrogen
  • Ethinyloestradiol is a synthetic form of 17-beta-estradiol that is more resistant to metabolism in the liver than natural estradiol but has the same biological activity. 
  • oestradiol valerate is a prodrug (or precursor) of natural human oestradiol and is converted to 17-beta-estradiol by esterase enzymes in the blood and liver.  It is an effective form of estrogen used for intramuscular administration (injection) as it is absorbed slowly and lasts longer that estradiol itself. 
  • Estrone or E1 becomes the most prominent form of natural estrogen during menopause, as estradiol drops, and is produced primarily in the adrenal glands.  Estrone is readily converted into a long lasting form estrone sulphate which concentrates in breast tissue of post-menopausal women and is thought to be involved the development of breast cancer, by being converted to estradiol.  
  • Estriol or E3 is the weakest of the three natural forms of oestrogen.  It is the prominent form of estogen during pregnancy and is produced by the placenta, but plays no significant role in non-pregnant women as it is mild, short acting and normally present in small amounts.
  • Conjugated oestrogens are a mixture of several different forms of estrogen (at least 10) isolated from horse urine.  They contain mainly forms of estrogen that are in the sulphate form and can be easily absorbed and converted to the active form estradiol.

Delivery methods for estrogens

Estrogen hormone replacement therapy is available in several different preparations and routes of administration.  These include:

  • Oral preparations which are subjected to metabolism by the liver and is associated with side effects, such as painful swollen breasts, nausea, headache.
  • Skin patches allow oestrogen to diffuse through the skin and into the blood and allows for lower doses to be used, as estrogen bypasses liver and is therefore, not subject to first pass metabolism by the liver.  It also provides more constant blood levels as it diffuses into the blood at a steady rate
  • Topical transdermal creams and gels which are rubbed into the skin so that the estrogen diffused through the skin directly into the blood circulation, allowing the estrogen to be released slowly through the skin. 

Products available for estrogen hormonal therapy

The most commonly used estrogens as part of a feminising regime for transgender hormone therapy are the more potent forms of estrogen including estradiol (17-beta-estradiol), oestradiol valerate and conjugated oestrogens.  Estriol can also be used but is less effective.

  • estradiol for oral administration, skin patch or injection
  • oestriol for oral administration
  • conjugated oestrogens for oral administration
  • oestradiol valerate for injection
Read more
5 Stars

Testimonials

Hear from more than 1000 happy customers!
Heart Icon
"Awesome service, notification provided when products are in stock & once ordered, are shipped promptly without issue."
Keren Sydney, AU • March 2023
Heart Icon
"Excellent service from a really professional company. I’m grateful for all the step by step updates during the coronavirus disruptions. Customer service support should be congratulated."
Denise UK • October 2020
Heart Icon
"I received my order today and the delivery was super fast and you made everything so quick and easy. You have been amazing. I will be ordering again soon."
Richard UK • March 2023
Heart Icon
"Thank you for being a terrific online pharmacy!"
Ellen TX, USA • February 2024
Heart Icon
"This company is excellent. The customer service is second to none. They are helpful and always willing to help in anyway they can. Medications are safe and sent promptly. Would recommend using them without any hesitation. "
PAUL UK • October 2021
Heart Icon
"Great web-site...Thanks"
John NY, USA • October 2021
Heart Icon
"Please be assured of how much I value and appreciate your kind attention and help with this matter. In-House Pharmacy could not hope to have a better ambassador! Thank you so very much!! "
Deborah FL, USA • March 2023
Heart Icon
"I really appreciate your quick response and excellent customer service!"
Deborah TX, USA • February 2024
Heart Icon
"Excellent Service - Products are good quality. Questions answered promptly. Very satisfied with this company."
D. TX, USA • February 2020
Heart Icon
"Products arrived sooner than expected! Ordering and payment are super easy. Staff are polite & very helpful. I’d recommend Inhouse Pharmacy to anyone. Thank you for your excellent service!"
Tom WI, USA • October 2023
 

This website uses cookies. View our policy and select your preferences here