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Estrogens

Our Estrogens class of Transgender products contain various forms of the female hormone estrogen for use in a feminizing regime for transgender hormone therapy during a gender reassignment programme. 

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. oestradiol, or the product name, e.g. Climara.

Our Estrogens class of Transgender products contain various forms of the female hormone estrogen for use in a feminizing regime for transgender hormone therapy during a gender reassignment programme. 

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. oestradiol, or the product name, e.g. Climara.
...Read more

Climara 50
Climara 50
Oestradiol
Out Of Stock
Climara 50 Patches (Sourced from Turkey)
Climara 50 Patches (Sourced from Turkey)
Oestradiol
Made in the USA for the Turkish market. Original branded product (Turkish writing) - comes with English language leaflet.
From $6.00 per Patch
Climara 100 Patches (Sourced from Turkey)
Climara 100 Patches (Sourced from Turkey)
Oestradiol
Made in the USA for the Turkish market. Original branded product (Turkish writing) - comes with English language leaflet.
Out Of Stock
Estradiol 2mg
Estradiol 2mg

Estradiol
Also known as Estrace
From $0.60 per Tablet
Estradot 25mcg (Australian Product)
Estradot 25mcg (Australian Product)
Oestradiol
From $2.67 per Patch
Estradot (Estradiol 75mcg) Patches
Estradot (Estradiol 75mcg) Patches
Estradiol
From $3.31 per Patch
Estradot 50mcg (Australian Product)
Estradot 50mcg (Australian Product)
Estradiol
From $3.00 per Patch
Estreva (Estradiol 0.1%) Gel
Estreva (Estradiol 0.1%) Gel
Estradiol
Out Of Stock
Estradot 100mcg (Australian Product)
Estradot 100mcg (Australian Product)
Estradiol
From $3.31 per Patch
Estrocon (Conjugated Estrogens 0.625mg) Tablets
Estrocon (Conjugated Estrogens 0.625mg) Tablets

Conjugated Estrogens
Also known as Premarin
From $0.69 per Tablet
Estrofem 1mg
Estrofem 1mg
Oestradiol
Also known as Estrace
From $0.74 per Tablet
Estrofem 2mg
Estrofem 2mg
Oestradiol
Also known as Estrace
From $0.76 per Tablet
Estrofem 2mg (Sourced from Turkey)
Estrofem 2mg (Sourced from Turkey)
Oestradiol
Also known as Estrace. Original branded product (Turkish writing) - comes with English language leaflet. Made in Denmark.
From $0.56 per Tablet
Progynon Depot 10mg/ml
Progynon Depot 10mg/ml
Estradiol Valerate 10mg/ml
DISCONTINUED PRODUCT
Discontinued
Ethinyloestradiol
Ethinyloestradiol
Ethinyloestradiol 10mcg
From $0.40 per Tablet
Kliogest
Kliogest
Oestradiol 2mg /Norethisterone 1mg
From $1.44 per Tablet
Kliovance
Kliovance
Estradiol 1mg/norethisterone acetate 0.5mg
From $1.44 per Tablet
Oestrogel (17B Estradiol 0.06%) Gel
Oestrogel (17B Estradiol 0.06%) Gel
17B Estradiol
Made in Belgium.
From $0.40 per Gram
Ovestin Cream 0.1% (Aspen)
Ovestin Cream 0.1% (Aspen)
Oestriol
From $1.50 per Gram
Ovestin Tablets (Oestriol 2mg)
Ovestin Tablets (Oestriol 2mg)
Oestriol
From $0.77 per Tablet
Premarin 0.3mg
Premarin 0.3mg
Conjugated Oestrogens
Out Of Stock
Premarin 0.625mg
Premarin 0.625mg
Conjugated Oestrogens
Out Of Stock
Premarin Cream 14gm/Tube
Premarin Cream 14gm/Tube
Conjugated Oestrogens
Out Of Stock
Estradiol Valerate Injection 100mg/5mL
Estradiol Valerate Injection 100mg/5mL
Estradiol 20mg/mL
From $292.50 per Vial
Sandrena 1g (Oestradiol)
Sandrena 1g (Oestradiol)
Oestradiol
From $0.64 per Dose
Progynova 1mg 3x28s
Progynova 1mg 3x28s
Oestradiol valerate
From $0.43 per Tablet
Progynova 2mg 3x28s
Progynova 2mg 3x28s
Oestradiol valerate
From $0.48 per Tablet
Estradiol Valerate Injection 200mg/5mL
Estradiol Valerate Injection 200mg/5mL
Estradiol 40mg/mL
From $477.50 per Vial
Progynova TS 50
Progynova TS 50
Estradiol Hemihydrate
Discontinued
Progynova TS 100
Progynova TS 100
Estradiol Hemihydrate
Discontinued

About estrogen

Estrogens are produced by the ovaries along with progesterone at certain stages of the menstrual cycle and their production is under control of follicle stimulating hormone (FSH) and luteunising hormone (LH) produced by the pituitary gland, which are in turn under the control of gonadotrophin releasing hormones produced by the hypothalamus in the brain.  

Estrogen is the main female hormone that stimulates development of female secondary sexual characteristics like breast development, body shape and regulating the menstrual cycle.  Therefore, estrogen is used as the main component of trangender hormone therapy for male to female transexuals while at the same time overriding the effects of testosterone.  

Different forms of estrogen

Estrogen exists in several forms and with different potencies:

  • Estradiol, specifically 17-beta-estradiol or E2, is the major and most active form of natural estrogen in the body produced by the ovaries and is responsible for the main actions of estrogen
  • Ethinyloestradiol is a synthetic form of 17-beta-estradiol that is more resistant to metabolism in the liver than natural estradiol but has the same biological activity. 
  • oestradiol valerate is a prodrug (or precursor) of natural human oestradiol and is converted to 17-beta-estradiol by esterase enzymes in the blood and liver.  It is an effective form of estrogen used for intramuscular administration (injection) as it is absorbed slowly and lasts longer that estradiol itself. 
  • Estrone or E1 becomes the most prominent form of natural estrogen during menopause, as estradiol drops, and is produced primarily in the adrenal glands.  Estrone is readily converted into a long lasting form estrone sulphate which concentrates in breast tissue of post-menopausal women and is thought to be involved the development of breast cancer, by being converted to estradiol.  
  • Estriol or E3 is the weakest of the three natural forms of oestrogen.  It is the prominent form of estogen during pregnancy and is produced by the placenta, but plays no significant role in non-pregnant women as it is mild, short acting and normally present in small amounts.
  • Conjugated oestrogens are a mixture of several different forms of estrogen (at least 10) isolated from horse urine.  They contain mainly forms of estrogen that are in the sulphate form and can be easily absorbed and converted to the active form estradiol.

Delivery methods for estrogens

Estrogen hormone replacement therapy is available in several different preparations and routes of administration.  These include:

  • Oral preparations which are subjected to metabolism by the liver and is associated with side effects, such as painful swollen breasts, nausea, headache.
  • Skin patches allow oestrogen to diffuse through the skin and into the blood and allows for lower doses to be used, as estrogen bypasses liver and is therefore, not subject to first pass metabolism by the liver.  It also provides more constant blood levels as it diffuses into the blood at a steady rate
  • Topical transdermal creams and gels which are rubbed into the skin so that the estrogen diffused through the skin directly into the blood circulation, allowing the estrogen to be released slowly through the skin. 

Products available for estrogen hormonal therapy

The most commonly used estrogens as part of a feminising regime for transgender hormone therapy are the more potent forms of estrogen including estradiol (17-beta-estradiol), oestradiol valerate and conjugated oestrogens.  Estriol can also be used but is less effective.

  • estradiol for oral administration, skin patch or injection
  • oestriol for oral administration
  • conjugated oestrogens for oral administration
  • oestradiol valerate for injection
...Read more

About estrogen

Estrogens are produced by the ovaries along with progesterone at certain stages of the menstrual cycle and their production is under control of follicle stimulating hormone (FSH) and luteunising hormone (LH) produced by the pituitary gland, which are in turn under the control of gonadotrophin releasing hormones produced by the hypothalamus in the brain.  

Estrogen is the main female hormone that stimulates development of female secondary sexual characteristics like breast development, body shape and regulating the menstrual cycle.  Therefore, estrogen is used as the main component of trangender hormone therapy for male to female transexuals while at the same time overriding the effects of testosterone.  

Different forms of estrogen

Estrogen exists in several forms and with different potencies:

  • Estradiol, specifically 17-beta-estradiol or E2, is the major and most active form of natural estrogen in the body produced by the ovaries and is responsible for the main actions of estrogen
  • Ethinyloestradiol is a synthetic form of 17-beta-estradiol that is more resistant to metabolism in the liver than natural estradiol but has the same biological activity. 
  • oestradiol valerate is a prodrug (or precursor) of natural human oestradiol and is converted to 17-beta-estradiol by esterase enzymes in the blood and liver.  It is an effective form of estrogen used for intramuscular administration (injection) as it is absorbed slowly and lasts longer that estradiol itself. 
  • Estrone or E1 becomes the most prominent form of natural estrogen during menopause, as estradiol drops, and is produced primarily in the adrenal glands.  Estrone is readily converted into a long lasting form estrone sulphate which concentrates in breast tissue of post-menopausal women and is thought to be involved the development of breast cancer, by being converted to estradiol.  
  • Estriol or E3 is the weakest of the three natural forms of oestrogen.  It is the prominent form of estogen during pregnancy and is produced by the placenta, but plays no significant role in non-pregnant women as it is mild, short acting and normally present in small amounts.
  • Conjugated oestrogens are a mixture of several different forms of estrogen (at least 10) isolated from horse urine.  They contain mainly forms of estrogen that are in the sulphate form and can be easily absorbed and converted to the active form estradiol.

Delivery methods for estrogens

Estrogen hormone replacement therapy is available in several different preparations and routes of administration.  These include:

  • Oral preparations which are subjected to metabolism by the liver and is associated with side effects, such as painful swollen breasts, nausea, headache.
  • Skin patches allow oestrogen to diffuse through the skin and into the blood and allows for lower doses to be used, as estrogen bypasses liver and is therefore, not subject to first pass metabolism by the liver.  It also provides more constant blood levels as it diffuses into the blood at a steady rate
  • Topical transdermal creams and gels which are rubbed into the skin so that the estrogen diffused through the skin directly into the blood circulation, allowing the estrogen to be released slowly through the skin. 

Products available for estrogen hormonal therapy

The most commonly used estrogens as part of a feminising regime for transgender hormone therapy are the more potent forms of estrogen including estradiol (17-beta-estradiol), oestradiol valerate and conjugated oestrogens.  Estriol can also be used but is less effective.

  • estradiol for oral administration, skin patch or injection
  • oestriol for oral administration
  • conjugated oestrogens for oral administration
  • oestradiol valerate for injection
...Read more

 

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