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APO-Gliclazide 80mg 500 Tablets/Pack


APO-Gliclazide 80mg 500 Tablets/Pack

APO-Gliclazide 80mg

 

Product Name
APO-Gliclazide 80mg 500 Tablets/Pack
Also known as Diamicron
Active Ingredient
Gliclazide 80mg
Manufacturer
Apotex
Product Type
Antihyperglycaemic (sulphonylurea)
Product expiry date we are currently shipping
Discontinued, no stock

This product has been discontinued, but we do have alternatives below.

Apo-Gliclazide tablets 80mg contain gliclazide, an oral antihyperglycaemic medication, used to control blood sugar levels in people with type-2 diabetes.

Apo-Gliclazide general information

What is Apo-Gliclazide used for?

Apo-Gliclazide tablets 80mg are an oral diabetes medication used to control blood sugar levels in people with mild to moderate type-2 diabetes mellitus (T2DM, also called non insulin-dependent diabetes or maturity onset diabetes) who are unable to achieve adequate glycaemic control (normal blood sugar levels) with diet and exercise alone. Apo-Gliclazide tablets 80mg can be used alone as monotherapy, in conjunction with diet and exercise, or in combination with other antihyperglycaemic medication (lowers blood sugar), like metformin, when a single drug does not provide adequate glycaemic control. Diabetes increases the risk of serious health complications, including diabetic retinopathy (damage to the retina in the eye with loss of vision), diabetic neuropathy (nerve damage) and diabetic nephropathy (kidney damage). Maintaining glycaemic control with Apo-Gliclazide tablets 80mg reduces the risk of developing these vascular complications.

How does Apo-Gliclazide work?

Apo-Gliclazide tablets 80mg contain gliclazide, an oral antihyperglycaemic medication belonging to the sulphonylurea group of drugs. Gliclazide in Apo-Gliclazide tablets 80mg controls blood glucose (sugar) primarily by acting directly on the beta cells, which are the insulin-producing cells of pancreatic islet tissue. It increases sensitivity of the beta cells to glucose and stimulates the cells to produce and release more insulin. Insulin is normally produced in response to food and increased blood glucose levels. This insulin release controls postprandial (after eating) blood glucose levels to maintain glycaemic control, which is impaired in diabetes. Gliclazide in Apo-Gliclazide tablets 80mg helps the body to produce sufficient insulin to maintain normal blood glucose levels after a meal as well as between meals and is effective for up to 24 hours. It is thought that as well as acting as an insulin secretagogue (stimulates insulin secretion) gliclazide in Apo-Gliclazide tablets 80mg also acts on insulin-responsive cells in the liver, muscle and fat cells to increase the number of receptors, which means that insulin control of glucose production by the liver and uptake of insulin into peripheral tissues for energy and storage, is more efficient and helps reduce insulin resistance, which is seen in type-2 diabetes. Gliclazide in Apo-Gliclazide has also been found to reduce the stickiness of the blood by reducing blood platelets sticking to the vessel wall, which initiates blood clot formation, and is thought to be a factor in the vascular complications of diabetes.

What does Apo-Gliclazide contain?

Apo-Gliclazide tablets 80mg contain the active ingredient gliclazide, an oral antihyperglycaemic used to lower blood sugar levels in type-2 diabetes.

Treating type 2 diabetes with Apo-Gliclazide

Apo-Gliclazide tablets 80mg contain gliclazide, an oral antihyperglycaemic medication, used to control blood sugar levels in people with type-2 diabetes mellitus (also called non insulin-dependent diabetes or maturity onset diabetes) who are unable to achieve adequate glycaemic control (normal blood sugar levels) with diet and exercise alone. Insulin is normally produced in response to food and increased blood glucose levels and insulin release controls postprandial (after eating) blood glucose levels to maintain glycaemic control, which is impaired in diabetes. Gliclazide in Apo-Gliclazide tablets 80mg controls blood glucose (sugar) primarily by acting directly on the beta cells, which are the insulin-producing cells of pancreatic islet tissue. It increases sensitivity of the beta cells to glucose and stimulates the cells to produce and release more insulin. Gliclazide in Apo-Gliclazide tablets 80mg helps the body to produce sufficient insulin to maintain normal blood glucose levels after a meal as well as between meals. Gliclazide in Apo-Gliclazide tablets 80mg also acts on insulin-responsive cells in the liver, muscle and fat cells to increase the number of receptors, which means that insulin control of glucose production by the liver and uptake of insulin into peripheral tissues for energy and storage, is more efficient and helps reduce insulin resistance, which is seen in type-2 diabetes. Gliclazide in Apo-Gliclazide has also been found to reduce the stickiness of the blood by reducing blood platelets sticking to the vessel wall, which initiates blood clot formation, and is thought to be a factor in the vascular complications of diabetes. Maintaining glycaemic control with Apo-Gliclazide tablets 80mg reduces risk of serious health complications associated with diabetes, including diabetic retinopathy (damage to the retina in the eye with loss of vision), diabetic neuropathy (nerve damage) and diabetic nephropathy (kidney damage).

What are the side effects of Apo-Gliclazide?

The most commonly reported side effects when taking Apo-Gliclazide include: gastrointestinal complaints like nausea, diarrhoea, constipation and stomach or abdominal pain; allergic skin reactions like, redness (erythema), itching (pruritus), hives (urticaria); also dizziness, drowsiness, headache, visual disturbances, confusion, malaise and tremor, which are usually transient and may be signs of hypoglycaemia. A more serious side effect of taking Apo-Gliclazide tablets 80mg is severe hypoglycaemia (very low blood glucose), as gliclazide continues to work between meals to reduce blood sugar levels, so it is important to eat regularly; also certain other conditions like liver or kidney problems, or taking other medications like beta blockers, can make you more susceptible to hypoglycaemia. Other symptoms of hypoglycaemia include headache, hunger, restlessness, loss of consciousness, which can result in coma.

What is hypoglycaemia (hypo)

Having a hypo is an unpleasant episode experienced by diabetics and refers to extreme hypoglycaemia or very low blood glucose. Gliclazide in Apo-Gliclazide tablets 80mg continue to work between meals to reduce blood sugar levels and therefore if glucose levels fall too low, by missing a meal or waiting too long between eating, severe hypoglycaemia, which is very low blood glucose, can be the result. Symptoms of hypoglycaemia include headache, hunger, nausea, vomiting, restlessness, sensory disturbances, delirium, loss of consciousness, which can result in shallow respiration, bradycardia (slow heart beat) and coma.

When should Apo-Gliclazide not be used?

You should not use Apo-Gliclazide tablets 80mg if you:
  • are allergic to gliclazide or any other sulphonylurea or any ingredients in Apo-Gliclazide
  • are pregnant or are breastfeeding
  • have kidney, liver or thyroid disease
  • have type 1 (insulin-dependent) diabetes or suffer from diabetic coma or diabetic ketoacidosis
  • have G6PD deficiency as you may be at risk of haemolytic anaemia
  • are malnourished or have adrenal or pituitary insufficiency, as this may increase risk of hypoglycaemia
  • drink alcohol as this can cause a serious reaction
  • are taking medicines that interact with Apo-Gliclazide: including the antifungals miconazole and fluconazole, non steroidal anti-inflammatory agents (NSAID) like phenylbutazone, salicylate analgesicis like aspirin, beta-blockers like propranolol for high blood pressure and certain heart conditions, clonidine for high blood pressure, ACE Inhibitors like benezapril for high blood pressure, cimetidine for peptic ulcers, monoamine oxidase inhibitors for depression, probenecid for gout, the anticoagulant warfarin, the antibiotic chloramphenicol, sulphonamide antibiotics, danazol for hormone treatment, the antipsychotic chlorpromazine, corticosteroids for inflammation, bronchodilators like salbutamol, thiazides and other diuretics, thyroid hormones, oestrogens and progestogens for oral contraceptives and HRT, phenytoin for epilepsy, nicotinic acid for high cholesterol, calcium channel blocking drugs like verapamil for angina, isoniazid for tuberculosis

What medications interact with Apo-Gliclazide?

Several medications interact with Apo-Gliclazide tablets 80mg and should either not be taken while you are taking Apo-Gliclazide or only after discussion and instruction from your doctor:
  • Drugs that affect Apo-Gliclazide and cause hypoglaemia (low blood sugar) by increasing its glucose-lowering effect: the antifungals miconazole and fluconazole, non steroidal anti-inflammatory agents (NSAID) like phenylbutazone, salicylate analgesics like aspirin, beta-blockers like propranolol for high blood pressure and certain heart conditions, ACE Inhibitors like benezapril for high blood pressure, cimetidine for peptic ulcers, monoamine oxidase inhibitors for depression, probenecid for gout, the anticoagulant warfarin, the antibiotic chloramphenicol, sulphonamide antibiotics, bronchodilators like salbutamol, clonidine for high blood pressure
  • Drugs that affect Apo-Gliclazide and cause hyperglycaemia (high blood sugar) by reducing its glucose-lowering effect: Danazol for hormone treatment, the antipsychotic chlorpromazine, corticosteroids for inflammation, bronchodilators like salbutamol, thiazides and other diuretics, thyroid hormones, oestrogens and progestogens for oral contraceptives and HRT, phenytoin for epilepsy, nicotinic acid for high cholesterol, calcium channel blocking drugs like verapamil for angina, isoniazid for tuberculosis, clonidine for high blood pressure

How should Apo-Gliclazide be taken?

You should take your Apo-Gliclazide tablets 80mg swallowed whole with a glass of water just before breakfast of if you only have a light breakfast, then take your Apo-Gliclazide tablets just before your midday meal. It is important that you do not skip a meal while taking Apo-Gliclazide tablets 5mg. The dose you take depends on how well you respond and your doctor may increase your dose until your blood glucose has reached normal levels and remains controlled. If your dose is increased to more than 160mg per day you will be asked to take it in separate doses, morning and evening. You should continue to take your Apo-Gliclazide tablets 80mg for as long as recommended by your doctor, as they with help maintain your blood sugar levels but will not cure your diabetes.

How long should you take Apo-Gliclazide?

You should continue to take your Apo-Gliclazide tablets 80mg for as long as recommended by your doctor, as they with help maintain your blood sugar levels but will not cure your diabetes.

Missed dose of Apo-Gliclazide

If you miss a dose of Apo-Gliclazide tablets 80mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Apo-Gliclazide be stored?

You should store your Apo-Gliclazide below 25°C in a cool dry place.


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