Progynova (Oestradiol) Tablets 1mg 84 Tablets/Pack
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Progynova general information
What is Progynova used for?
Progynova tablets 1mg are a hormone replacement therapy (HRT) used to substitute for a lack of oestrogen production by the ovaries that happens during menopause or following surgical removal of the ovaries. Progynova tablets 1mg help relieve symptoms of menopause caused by oestrogen deficiency, such as hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy. Progynova tablets 1mg can be used alone or in combination with a progestogen in women with an intact uterus. Progynova tablets 1mg are also used to help prevent postmenopausal bone loss (osteoporosis) and reduce risk of fracture. Progynova stimulates the development of female sexual characteristics, and is used as the oestrogen component of transgender hormone therapy for male to female transsexuals.
How does Progynova work?
Progynova tablets 1mg contain oestradiol valerate, a prodrug (or precursor) of natural human oestradiol, which is the major and most active form of the female sex hormone oestrogen, produced by the ovaries. Oestrogen is a steroid hormone that binds to specific receptors inside oestrogen-responsive cells and stimulates them to make proteins involved in producing female sexual characteristics, such as breast development and in regulating the menstrual cycle. Oestrogen also has several other actions in various metabolic processes including maintaining bone mass and lipid (fat) metabolism.
What does Progynova contain?
Progynova tablets 1mg contain the active ingredient oestradiol valerate, a prodrug (or precursor) of natural human 17β-oestradiol, which is the major and most active form of the female secondary sex hormone oestrogen produced by the ovaries, and is responsible for the development of female sexual characteristics. They also contain lactose monohydrate, maize starch, polyvidone 25 000, talc, magnesium stearate, sucrose, polyvidone 700 000, macrogol 6000, calcium carbonate, glycerol 85%, titanium dioxide, ferric oxide pigment (yellow), montanglycol wax
Treating symptoms of menopause with Progynova
Progynova tablets 1mg are used for hormone replacement therapy (HRT) to substitute for the lack of oestrogen produced by the ovaries. As menopause approaches, oestrogen production by the ovaries begins to slow down and then cease altogether, which causes a wide range of moderate to severe symptoms, including hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration, loss of energy and bone loss (osteoporosis). HRT using Progynova tablets 1mg can help relieve these symptoms.
Progynova for hormone replacement therapy
Progynova 1mg tablets substitute for the loss of oestrogen production by the ovaries that occurs during menopause or following surgical removal of the ovaries. Progynova contains oestradiol, an active form of the female hormone oestrogen that alleviates menopausal symptoms, such as hot flushes, night sweats, sleeplessness, dry vagina, headaches, mood swings, lack of concentration loss of energy and bone loss (osteoporosis).
Progynova for transgender treatment
Progynova tablets 1mg can be used as part of a gender reassignment program for male to female transsexuals, by providing a source of oestradiol, an active form of the female hormone oestrogen. Progynova tablets 1mg stimulate the development of female secondary sexual characteristics, such as breast development and also induce metabolic changes such as fat distribution to redefine the general body shape.
Progynova for feminising hormone therapy
Progynova tablets 1mg contain oestradiol valerate, a prodrug (or precursor) of natural human 17β-oestradiol, the most feminising form of the female hormone oestrogen, which provides a very effective means of feminisation when used as part of a gender reassignment program for male to female transsexuals. Progynova 1mg stimulates the development of female secondary sexual characteristics, such as breast development and also induces metabolic changes such as fat distribution to redefine the general body shape, while at the same time Progynova overrides the effects of testosterone.
What are the side effects of Progynova?
The most commonly reported side effects when taking Progynova tablets 1mg include: breast tenderness, breast pain, abdominal pain, nausea, oedema, and headache, skin rash and itching, insomnia and depression. More severe side effects include changes in liver function at higher doses and increased risk of dementia if initiated in women aged 65 or older.
What are the health risks of Progynova?
Long-term HRT with Progynova tablets 1mg does have associated health risks, including an increased risk of breast cancer, endometrial cancer, stroke and deep vein thrombosis. For women with an intact uterus adding a progestogen to an oestrogen replacement regimen like Progynova for at least 10 days per cycle is recommended to reduce the risk of endometrial cancer.
When should Progynova not be used?
You should not use Progynova tablets 1mg if you:
- are allergic to oestradiol valerate or any of the ingredients in Progynova tablets
- are pregnant, planning to become pregnant or breastfeeding
- have a past or family history of carcinoma of the breast, endometrial carcinoma or liver disease
- have deep venous thrombosis, thromboembolic disorders, cerebral vascular accident associated with oestrogen use
- have severe liver disease
- have severe hypertriglyceridemia (high lipid levels in the blood)
- have abnormal genital bleeding of unknown cause
- A diabetic taking antidiabetics or insulin, without discussion with your doctor, as Progynova may affect your glucose tolerance
- are taking other medications that may interact with Progynova and reduce its clinical efficacy, such as anticonvulsants like phenytoin and carbamazepin, barbiturates, anti-infectives like rifampicin, rifabutin, nevirapine, antibiotics like penicillin and tetracycline,.
How should Progynova be taken?
You should take Progynova tablets 1mg with a glass of water once a day, preferably at the same time each day, until all 28 tablets have been taken. The dose you take depends on your condition and should be as recommended by your doctor. When you have finished each pack, start the next pack immediately. You can start taking Progynova tablets 1mg on any convenient day unless you are still having menstrual bleeding, in which case take the first tablet on day 5 of bleeding.
How long should you take Progynova?
Each pack of Progynova 1mg tablets is a calendar pack of 28 tablets. You should take Progynova 1mg tablets for as long as your doctor recommends.
Missed dose of Progynova
If you miss a dose of Progynova take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose. If you forget to take a tablet for more than 12 to 24 hours, irregular bleeding may occur.
How should Progynova be stored?
Keep Progynova tablets in their calendar pack until used. Store at room temperature below 25°C, keep away from direct sunlight and do not refrigerate.