Antirobe Capsules (Clindamycin) 25mg

Antirobe general information

What is Antirobe used for?

Antirobe capsules 25mg are used to treat bacterial infections in dogs due to susceptible bacteria, including Staphylococcus, Streptococcus, Bacteriodes, Prevotella and Fusobacterium.   Antirobe capsules 25mg are used in the treatment in dogs of infected wounds, abscesses, dental infections and osteomyelitis, which is an infection of the bone or bone marrow.  Osteomyelitis may be caused by an infection from another part of the body reaching the bone through the blood, or the bone may become infected from an accident involving the bone.  Antirobe capsules 25mg are specially formulated for treatment of bacterial infections in dogs, but dry capsules are not recommended for cats.

How does Antirobe work?

Antirobe capsules 25mg contain the antibiotic clindamycin, a lincosamide antibiotic with bacteriostatic action that is used to treat bacterial infections in dogs.  Clindamycin in Antirobe capsules 25mg binds to the bacterial ribosome, a structure involved in protein synthesis and this inhibits the early stages of bacterial protein synthesis, so that the bacteria cannot make important proteins required for survival of the bacteria and this kills the bacteria.  This action of clindamycin in Antirobe capsules 25mg reduces bacterial growth and prevents the spread of infection.  Clindamycin in Antirobe capsules 25mg concentrates in neutrophils, the white blood cells that fight infection, which concentrates the antibiotic at the site of infection.  Clindamycin in Antirobe capsules 25mg is lipid soluble and, therefore, penetrates many body fluids and tissues, such as soft tissue, bone and joints; it also penetrates biofilms found in dental and bone infections it also penetrates biofilms found in dental and bone infections.   

What does Antirobe contain?

Antirobe capsules 25mg contain the active ingredient clindamycin hydrochloride, an antibiotic used to treat bacterial infections in dogs. 

Treating Bacterial infection in dogs with Antirobe

Antirobe capsules 25mg contain the antibiotic clindamycin that is used to treat bacterial infections in dogs.  Clindamycin in Antirobe capsules 25mg is effective against a wide range of aerobic and anaerobic bacteria including Staphylococcus, Streptococcus, Bacteriodes, Prevotella and Fusobacterium that cause conditions like infected wounds, abscesses, dental infections.  Clindamycin in Antirobe capsules 25mg blocks bacterial protein synthesis, which kills the bacteria reducing bacterial growth and preventing the spread of infection.

Antirobe for osteomyelitis in dogs

Antirobe capsules 25mg contain the antibiotic clindamycin that is used to treat osteomyelitis, an infection of the bone or bone marrow.  Osteomyelitis may be caused by an infection from another part of the body reaching the bone through the blood, or the bone may become infected from an accident involving the bone.  Clindamycin in Antirobe capsules 25mg blocks bacterial protein synthesis, which kills the bacteria reducing bacterial growth and preventing the spread of infection.

What are the side effects of Antirobe?

The most commonly reported side effects when taking Antirobe capsules 25mg include vomiting and diarrhoea usually caused by the antibiotic effect of clindamycin in the intestines, which allows overgrowth of the toxin-producing bacterium clostridium and some yeasts. 

When should Antirobe not be used?

You should not administer Antirobe capsules 25mg if your dog:

• is allergic to clindamycin or any ingredients in Antirobe
• is pregnant or lactating
• have kidney or liver disease, without close monitoring
• are taking medicines that interact with Antirobe, including the antibiotic erythromycin, neuromuscular blocking agents

How should Antirobe be given?

You should give Antirobe capsules 25mg to your dog every 12 hours for 7–10 days, and for up to 28 days.  For osteomyelitis, you should administer Antirobe capsules 25mg for at least 28 days.  The capsules are tasteless and do not dissolve in the mouth.  You should continue to give Antirobe capsules 25mg to your dog for as long as recommended by your vet.

The correct dose for your dog is 5.5-33 mg/kg body weight (2.5-15mg/lb). 

Use the following guide of number of Antirobe capsules 25mg per kg body weight, to help you administer the correct dose:

• 2-5kg:         1 x 25mg capsule
• 6-14mg:      1 x 75mg capsule
• 15-29mg     1 x 150mg capsule
• 30-49mg     2 x 150mg capsule
• 50-59mg     3 x 150mg capsule

How long should you take Antirobe?

You should continue to give Antirobe capsules 25mg to your dog for as long as recommended by your vet, which is usually 7-28 days or at least 28 days for osteomyelitis.

Missed dose of Antirobe

If you miss a dose of Antirobe capsules 25mg administer it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not administer a double dose.

How should Antirobe be stored?

You should store your Antirobe capsules 25mg below 25°C in a cool dry place.