Entresto 97/103 (Sacubitril & Valsartan 97.2mg/102.8mg) 56 Tablets/ Pack

General Information

What is Entresto tablets 97/103 mg used for?

Entrestro 97/103 mg is a combination of sacubitril, a neprilisin inhibitor, and valsartan, an angiotensin II receptor blocker, and is used

 • to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. Benefits are most clearly evident in patients with left ventricular ejection fraction (LVEF) below normal.

 • for the treatment of symptomatic heart failure with systemic left ventricular systolic dysfunction in paediatric patients aged one year and older.

Entresto 49/51 reduces NT-proBNP and is expected to improve cardiovascular outcomes.

How does Entresto tablets 97/103 mg work?

Entresto 97/103 mg contain the active ingredients sacubitril and valsartan.

 It is an angiotensin receptor neprilysin inhibitor (ARNI), which contains two active ingredients: sacubitril (a neprilysin inhibitor), and valsartan (an angiotensin receptor blocker or ARB).

Entresto works by blocking the changes caused by the enzyme neprilysin, and angiotensin II. As a result, blood vessels relax and less water is kept by the body which is useful to treat heart failure.

What does Entresto tablets 97/103 mg contain?

Entresto tablets 97/103 mg contain the active ingredients 97.2 mg sacubitril and 102.8 mg valsartan in combination.

The inactive ingredients (excipients) make the tablet and coating consist of:

Microcrystalline cellulose;Crospovidine; Low- subsitituted hydroproxypropyl cellulose;magnesium stearate (vegetable origin);colloidal silicone dioxide;talc;Hypromellose (film coating);macrogol 4000;Titanium dioxide (E171); Iron oxides

What are the side effects of Entresto tablets 97/103 mg

If any of the side effects listed below becomes severe, tell your Health Professional

 Very common (may affect more than 1 in 10 people)

• low blood pressure, which can cause symptoms of dizziness and light-headedness (hypotension)

 • high level of potassium in the blood, shown in a blood test (hyperkalaemia)

• decreased kidney function (renal impairment)

Common (may affect up to 1 in 10 people)

 • cough

• dizziness

 • diarrhoea

• low level of red blood cells, shown in a blood test (anaemia)

 • tiredness (fatigue)

 • (acute) inability of the kidney to work properly (renal failure)

• low level of potassium in the blood, shown in a blood test (hypokalaemia)

 • headache

 • fainting (syncope)

 • weakness (asthenia)

 • feeling sick (nausea)

• low blood pressure (dizziness, light-headedness) when switching from sitting or lying to standing position

• gastritis (stomach pain, nausea)

 • spinning sensation (vertigo)

 • low level of sugar in the blood, shown in a blood test (hypoglycaemia)

When should Entresto tablets 97/103 mg not be used?

Contraindications

 • Hypersensitivity to the active substance, sacubitril, valsartan, or to any of the excipients.

 • Concomitant use with ACE (angiotensin converting enzyme) inhibitors. Do not administer Entresto within 36 hours of switching from or to an ACE inhibitor 

• Known history of angioedema related to previous ACE inhibitor or ARB therapy.

• Hereditary or idiopathic angioedema 

• Concomitant use with aliskiren in patients with Type 2 diabetes 

• Severe hepatic impairment, biliary cirrhosis and cholestasis 

• Pregnancy

What medications interact with Entresto tablets 97/103 mg 

Some medicines may interfere with Entresto. These include:

• Statins, a medicine used to lower cholesterol levels e.g. atorvastatin

 · Sildenafil, a medicine used to treat erectile dysfunction and certain types of high blood pressure

• Medicines that increase the amount of potassium in the blood, including potassium sparing diuretics, a medicine used to reduce excess fluid in your body, e.g. amiloride

 · Medicines used to treat pain and arthritis, called nonsteroidal anti-inflammatory drugs (NSAID) or selective cyclo-oxygenase-2 inhibitors ( COX-2 ) inhibitors, e.g. ibuprofen

• Lithium, a medicine used to treat some types of depression
• Frusemide, a medicine used to reduce excess fluid in the body
• Metformin, a medicine used to control blood glucose for diabetes

 · Some antibiotics, e.g. rifampicin, a medicine used to treat certain infections

• Cyclosporin, a medicine to treat certain problems with the immune system, or to help prevent organ transplant rejection
• Ritonavir, a medicine used to treat HIV/AIDS infection.

 Tell your doctor if you take potassium supplements or salt substitutes that contain potassium. Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect Entresto.

How should Entresto tablets 97/103 mg be used and for how long?

Always consult your Health Professional on how Entresto tablets 97/103 mg should be taken.

• Usually one tablet twice daily (morning and evening)
• Swallow Entresto 97/103 mg tablets whole
• Can be taken with or without food

Adults;

•  Usually start by taking a 24 mg/26 mg or 49 mg/51 mg tablet twice a day (one tablet in the morning and one tablet in the evening). Your doctor will decide your exact starting dose based on which medicines you have been taking previously and your blood pressure. Your doctor will then adjust the dose every 2-4 weeks depending on how you respond to the treatment until the best dose for you is found.
•  The usual recommended target dose is 97 mg/103 mg twice a day (one tablet in the morning and one tablet in the evening).

Children and adolescents (one year and older) ;

• The starting dose is based on body weight and other factors including previously taken medicines. The Health Professional will adjust the dose every 2-4 weeks until the best dose is found.

Missed dose of Entresto tablets 97/103 mg

If you miss a dose of Entresto tablets 97/103 mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Entresto tablets 97/103 mg be stored?

You should store your Entresto tablets 97/103 mg below 30 degree and protect from moisture, sunlight and heat.