Entresto 24/26 (Sacubitril & Valsartan 24.3mg/ 25.7mg) 56 Tablets/ Pack

General Information

What is Entresto tablets 24/26 mg used for?

Entrestro 24/26 is a combination of sacubitril, a neprilisin inhibitor, and valsartan, an angiotensin II receptor blocker, and is used

 • to reduce the risk of cardiovascular death and hospitalization for heart failure in adult patients with chronic heart failure. Benefits are most clearly evident in patients with left ventricular ejection fraction (LVEF) below normal.

 • for the treatment of symptomatic heart failure with systemic left ventricular systolic dysfunction in paediatric patients aged one year and older.

Entresto 24/26 reduces NT-proBNP and is expected to improve cardiovascular outcomes.

How does Entresto tablets 24/26 mg work?

Entresto 24/26mg contains the active ingredients sacubitril and valsartan.

 It is an angiotensin receptor neprilysin inhibitor (ARNI), which contains two active ingredients: sacubitril (a neprilysin inhibitor), and valsartan (an angiotensin receptor blocker or ARB).

Entresto works by blocking the changes caused by the enzyme neprilysin, and angiotensin II. As a result, blood vessels relax and less water is kept by the body which is useful to treat heart failure.

What does Entresto tablets 24/26 mg contain?

Entresto tablets 24/26 mg contain the active ingredients 24.3 mg sacubitril and 25.7 mg valsartan in combination.

The inactive ingredients (excipients) make the tablet and coating consist of:

Microcrystalline cellulose; Crospovidine; Low-subsitituted hydroproxypropyl cellulose; magnesium stearate (vegetable origin); colloidal silicone dioxide; talc; Hypromellose (film coating); macrogol 4000; Titanium dioxide (E171); Iron oxides

What are the side effects of Entresto tablets 24/26 mg

• Hypotension (low blood pressure)
• Hyperkalaemia (high potassium)
• Renal impairment
• Angioedema (rare)

When should Entresto tablets 24/26 mg not be used?

Contraindications

 • Hypersensitivity to the active substance, sacubitril, valsartan, or to any of the excipients.

 • Concomitant use with ACE (angiotensin converting enzyme) inhibitors. Do not administer Entresto within 36 hours of switching from or to an ACE inhibitor 

• Known history of angioedema related to previous ACE inhibitor or ARB therapy.

• Hereditary or idiopathic angioedema 

• Concomitant use with aliskiren in patients with Type 2 diabetes 

• Severe hepatic impairment, biliary cirrhosis and cholestasis 

• Pregnancy

What medications interact with Entresto tablets 24/26 mg 

Some medicines may interfere with Entresto. These include:

• Statins, a medicine used to lower cholesterol levels e.g. atorvastatin

 · Sildenafil, a medicine used to treat erectile dysfunction and certain types of high blood pressure

• Medicines that increase the amount of potassium in the blood, including potassium sparing diuretics, a medicine used to reduce excess fluid in your body, e.g. amiloride

 · Medicines used to treat pain and arthritis, called nonsteroidal anti-inflammatory drugs (NSAID) or selective cyclo-oxygenase-2 inhibitors ( COX-2 ) inhibitors, e.g. ibuprofen

• Lithium, a medicine used to treat some types of depression
• Frusemide, a medicine used to reduce excess fluid in the body
• Metformin, a medicine used to control blood glucose for diabetes

 · Some antibiotics, e.g. rifampicin, a medicine used to treat certain infections

• Cyclosporin, a medicine to treat certain problems with the immune system, or to help prevent organ transplant rejection
• Ritonavir, a medicine used to treat HIV/AIDS infection.

 Tell your doctor if you take potassium supplements or salt substitutes that contain potassium. Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect Entresto.

How should Entresto tablets 24/26 mg be used and for how long?

• Usually one tablet twice daily (morning and evening)
• Swallow Entresto 24/26mg tablets whole
• Can be taken with or without food
• Entresto tablet 24/26mg is commonly the starting dose especially if blood pressure is on the low side: kidney function is not perfect: new type of medication to patient
• The dose can be increased slowly if tolerated.

Always consult your Health Professional on how Entresto tablets 24/26 mg should be taken.

Missed dose of Entresto tablets 24/26 mg

If you miss a dose of Entresto tablets 24/26 mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Entresto tablets 24/26 mg be stored?

You should store your Entresto tablets 24/26 mg below 30 degree and protect from moisture, sunlight and heat.