Prokinex 10mg (domperidone)
Prokinex 10mg (Domperidone) 100 Tablets/Pack
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Prokinex general information
What is Prokinex used for?
Prokinex tablets 10mg are used to treat acute symptoms of nausea and vomiting; also to help relieve discomfort due to gastroparesis (delayed emptying of the stomach) with symptoms including not being able to finish a meal, sense of fullness after a meal, abdominal distension or swelling (bloating), loss of appetite and epigastric pain or discomfort. Prokinex tablets 10mg are also used to relive symptoms symptoms like bloating, fullness, heartburn and flatulence that cause discomfort when the digestive system is out of rhythm or you have eaten too much. Prokinex tablets 10mg may also help relieve symptoms of nausea caused by some medications, such as anti-cancer drugs and medications used for Parkinson’s disease. Another use for Vomistop is to increase breast milk production, as a side effect of its intended use.
How does Prokinex work?
Prokinex tablets 10mg contains domperidone, a dopamine antagonist that acts as an antiemetic (prevents nausea and vomiting) and as a gastrokinetic (stimulates gastrointestinal mobility). Nausea and vomiting are triggered when the chemoreceptor trigger zone (CTZ) in the brain is stimulated, and this causes nerve impulses to be sent to the vomiting centre of the brain, which contains receptors for neurotransmitters like serotonin (5HT) and dopamine. The CTZ can be activated by two mechanisms; either indirectly by transmission of nerve impulses sent to the brain from the stomach when it has been irritated, or directly by chemicals or drugs that are circulating in the blood and stimulate receptors in the brain; both pathways induce the vomiting reflex. The chemoreceptor trigger zone (CTZ) is located in the area postrema of the brain, which is not protected by the blood-brain barrier and therefore, is readily accessible to circulating toxins and drugs. Domperidone in Prokinex tablets 10mg works by blocking the action of the chemical messenger dopamine and this stops the transmission of messages from the irritated or upset stomach to the brain, preventing the brain triggering the vomiting response. Domperidone in Prokinex tablets 10mg also blocks the same chemical messengers in the upper digestive system. This relieves dysmobility, which is when food processing slows down causing uncomfortable symptoms. Prokinex tablets 10mg restore the natural rhythm of muscle contraction and relaxation in the stomach, which helps push food through the digestive system and prevents vomiting.
What does Prokinex contain?
Prokinex tablets contain the active ingredient domperidone10mg, an antiemetic used to relieve nausea and vomiting. They also contain lactose monohydrate, maize starch, microcrystalline cellulose, sodium lauryl sulphate, povidone K 30, colloidal anhydrous silica, magnesium stearate.
Treating nausea and vomiting with Prokinex
Prokinex tablets 10mg contain domperidone, a dopamine antagonist that is used as antiemetic (prevents nausea and vomiting) to treat acute nausea and vomiting in response to a toxin; also for symptomatic relief of gastrointestinal disorders such as delayed emptying of the stomach or when the digestive system is out of rhythm causing symptoms including discomfort, bloating, fullness, heartburn, regurgitation of bile, abdominal pain and flatulence. Prokinex tablets 10mg works by blocking the action of the chemical messenger dopamine in the vomiting centre of the brain and in the upper intestine, and this prevents nausea and vomiting and restores the natural rhythm of the digestive system, relieving symptoms caused by gastrointestinal disorders.
How does Prokinex help with breastfeeding?
If you are having trouble producing enough breast milk you can use Prokinex tablets 10mg to help with breastfeeding. Domperidone, the active ingredient of Prokinex tablets 10mg, increases blood levels of the hormone prolactin, which stimulates milk production in a new mother’s breast cells. This is an indirect result of blocking the chemical messenger dopamine, which is also how Prokinex tablets 10mg prevents nausea and vomiting. Prokinex tablets 10mg does pass from the blood into breast milk, however, it is present in small amounts and there is no indication that it will harm the baby. Prokinex tablets 10mg has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production.
What are the side effects of Prokinex?
The most commonly reported side effects when taking Prokinex tablets 10mg include headache, abdominal cramps and dry mouth. Because Prokinex tablets 10mg does not cross the blood brain barrier it does not cause what are known as extrapyramidal side effects, like convulsion and involuntary muscle actions that can be associated with some dopamine blocking medications. However, for the same reason Prokinex tablets 10mg can increase the production of the hormone prolactin, which stimulates breast milk secretion, and this can cause breast enlargement (gynaecomastia) and temporary stoppage of periods (amenorrhoea). These side effects will stop as soon as you stop taking Prokinex tablets 10mg.
When should Prokinex not be used?
You should not use Prokinex tablets 10mg if you:
- are allergic to domperidone or any ingredients in Prokinex
- have kidney or liver disease
- have a condition where increasing gut motility could be harmful, such as gastrointestinal haemorrhage, mechanical obstruction or a perforation
- have a pituitary tumour that causes over-production of prolactin (prolactinoma)
- have an intolerance to lactose, a lactose malabsorption or a genetic disorder leading to accumulation of galactose in the blood (galactosaemia), as lactose is used to coat the tablets
- are taking medicines that interact with Prokinex and prevent one or both drugs working effectively including the antifungals ketoconazole and fluconazole, antibiotics containing erythromycin, clarithromycin or telithromycin; amiodarone for rapid heartbeat, ritonavir for HIV
How should Prokinex be taken?
You should take your Prokinex tablets 10mg swallowed whole with a glass of water 15 to 30 minutes before meals. If you are over 16, you can take a tablet three times a day and at bedtime, if necessary, but no more than four tablets in 24 hours. You should continue to take Prokinex tablets 10mg for as long as recommended by your doctor, however, it is not intended for long-term use and you should not continue to take it for more than two weeks, unless recommended by your doctor.
How long should you take Prokinex?
You should continue to take Prokinex tablets 10mg for as long as recommended by your doctor, however, it is not intended for long-term use and you should not continue to take it for more than two weeks, unless recommended by your doctor.
Missed dose of Prokinex
If you miss a dose of Prokinex tablets 10mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.
How should Prokinex be stored?
You should store your Prokinex tablets 10mg below 25°C in a cool dry place.