Brinov (Capecitabine 500mg)
Brinov (Capecitabine 500mg) 120 Tablets/Pack
Also known as Xeloda
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Brinov general information
What is Brinov used for?
Brinov tablets 500mg are used as oral chemotherapy to treat various cancers. Brinov 500 is used as single agent for adjuvant treatment following surgery to remove the primary tumour for Dukes’ stage C colon cancer, which is an advanced form of bowel cancer that has metastasised to local lymph nodes; also a first line monotherapy for metastatic colorectal cancer (cancer of the bowel and rectum). Brinov 500 is also used for first-line treatment of advanced gastric cancer in combination with a platinum-based regimen of chemotherapy. Brinov tablets 500mg is also used for metastatic breast cancer in combination with docetaxel (another chemotherapy medication) after treatment with anthracycline-containing chemotherapy has failed; also as monotherapy for metastatic breast cancer in patients who are resistant to other forms of chemotherapy or where they are not appropriate. Brinov tablets 500mg can be used as monotherapy or in combination with other cytotoxic cancer medications.
How does Brinov work?
Brinov tablets 500mg contain capecitabine, an oral chemotherapeutic drug belonging to the fluoropyrimidine group of drugs that is used to treat a variety of cancers. Capecitabine itself is not toxic but is a precursor of 5-fluorouracil (5-FU), a cytotoxic metabolite that is activated by specific enzymes that exist in normal cells but in higher levels in cancer cells, thereby producing more 5-FU at the tumour site than in normal cells. Capecitabine in Brinov 500 is an antimetabolite, which means that once metabolised, 5-FU is incorporated into newly synthesised nuclear material and causes metabolic errors that interfere with normal processing of DNA and RNA. Also 5-FU binds to an important enzyme in the formation of an essential component of DNA, which inhibits the synthesis of DNA. Both mechanisms contribute to the cytotoxic action of Brinov 500 that causes inhibition of cell growth and ultimately cell death of the cancer cells. Since capecitabine in Brinov tablets 500mg is a tumour-activated and tumour-selective cytotoxic drug, it targets rapidly growing tumour cells and has reduced effect on normal cells.
What does Brinov contain?
Brinov tablets contain the active ingredient contain capecitabine (500mg), a cytotoxic drug anti-neoplastic agent used to treat a variety of cancers. They also contain croscarmellose sodium, microcrystalline cellulose, hypromellulose, lactose monohydrate, magnesium stearate, titanium dioxide, Macrogol 6000, iron oxide red.
Treating cancers with Brinov
Brinov tablets 500mg contain capecitabine, an oral chemotherapeutic drug that is used to treat a variety of advanced cancers. These include locally advanced or metastatic breast cancer if other treatments have failed; Dukes’ stage C colon cancer, which is an advanced cancer that has been categorised following surgery as having metastasised to local lymph nodes; first line treatment for metastatic colorectal cancer (cancer of the bowel and rectum); first line treatment for gastric cancer (cancer of the stomach). Once swallowed, capecitabine in Brinov tablets 500mg is converted by an enzyme that exists in higher concentrations in tumour cells, to a cytotoxic metabolite that interferes with processing of nuclear material. This causes inhibition of cell growth and ultimately cell death of the cancer cells. Since capecitabine in Brinov 500 is a tumour-activated and rapid growing tumour cell-selective cytotoxic drug, it targets tumour cells and has reduced effect on normal cells. Brinov tablets 500mg can be used as monotherapy or in combination with other cytotoxic cancer medications.
What are the side effects of Brinov?
The most commonly reported side effects when taking Brinov tablets 500mg include gastrointestinal disorders (diarrhoea, nausea, vomiting, indigestion, abdominal pain), dehydration, stomatitis (inflammation of the mouth and lips, including cold sores and mouth ulcers), fatigue, asthenia (weakness or weariness), headache, dizziness, loss of appetite, anorexia, increased eye watering or irritation, conjunctivitis, skin rash, dry itchy skin, hair loss, hand-foot syndrome or palmar-plantar erythrodysesthesia (tingling, numbness, redness, swelling and pain on the palm of the hands and soles of the feet), fever.
When should Brinov not be used?
You should not use Brinov tablets 500mg if you:
- are allergic to capecitabine or any ingredients in Brinov
- are pregnant or are breastfeeding
- have kidney or liver disease
- have a heart problem or a history of cardiovascular disease, arrhythmias, angina pectoris
- have known dihydropyrimidine dehydrogenase (DPD) deficiency
- are taking medicines that interact with Capecitabine, including anticoagulants like warfarin, the anticonvulsant phenytoin, leucovorin for folic acid deficient anaemias, the antiviral sorivudine or analogues like brivudine, allopurinol for gout, antacids like aluminium hydroxide for indigestion, the antipsychotic clozapine
What medications interact with Brinov?
Several medications interact with Brinov tablets 500mg and should either not be taken while you are taking Brinov or only after discussion and instruction from your doctor:
- Drugs that cause a serious reaction with Brinov: anticoagulants like warfarin can cause altered coagulation or bleeding; the antiviral sorivudine or analogues like brivudine can cause fluoropyrimidine toxicity, which is potentially fatal; the antipsychotic clozapine increases risk of agranulocytosis (affecting white cell production in the bone marrow)
- Drugs that affect Brinov: leucovorin for folic acid deficient anaemias, allopurinol for gout, antacids like aluminium hydroxide for indigestion
- Drugs that are affected by Brinov: the anticonvulsant phenytoin
How should Brinov be taken?
You should take your Brinov tablets 500mg swallowed whole and with food (within 30 minutes of eating) twice daily, morning and evening. The dose you take and for how long depends on what you are being treated for and your doctor’s recommendation. In most cases you will take your Brinov 500 for the recommended number of weeks followed by a rest period. You may also be taking other cytotoxic medication as advised by your doctor. You should continue to take your Brinov tablets 500mg for as long as recommended by your doctor, which may be for several treatment cycles, depending on how well you respond.
How long should you take Brinov?
You should continue to take your Brinov tablets 500mg for as long as recommended by your doctor, which may be for several treatment cycles, depending on how well you respond.
Missed dose of Brinov
If you miss a dose of Brinov tablets 500mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.
How should Brinov be stored?
You should store your Brinov tablets 500mg below 25°C in a cool dry place.