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Imuran (Azathioprine 50mg) 100 Tablets/Pack


Imuran (Azathioprine 50mg) 100 Tablets/Pack

Imuran (Azathioprine 50mg)


Product Name
Imuran (Azathioprine 50mg) 100 Tablets/Pack
Active Ingredient
Azathioprine
Manufacturer
Product Type
Immunosuppressive
Product expiry date we are currently shipping
Nov 2022
Product Price List
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Imuran (Azathioprine) 50mg 100 Tablets
$0.50 per Tablet
|
$49.50 (USD) 
$49.50 (USD) 
Imuran (Azathioprine) 50mg 200 Tablets
$0.45 per Tablet
|
$89.00 (USD) 
$89.00 (USD) 

Imuran tablets 50mg contain azathioprine an immunosuppressant antimetabolite used to suppress the immune system to prevent transplant rejection and to treat a range of autoimmune disorders. 

Imuran general information

What is Imuran used for?

Imuran tablets 50mg are used to prevent transplant rejection by improving the survival of organ transplant such as kidney, heart and lung transplants Imuran tablets 50mg.  Organ transplants most commonly fail because the host immune system recognises the cells as foreign and attacks these cells, which causes destruction of the transplanted organ.  Imuran tablets 50mg can either be used as monotherapy alone or in combination with other drugs that influence the immune response such as corticosteroid medication, and are also used to reduce corticosteroid dependence following organ transplant. 

Imuran tablets 50mg are also used to suppress the immune system in the treatment of various autoimmune diseases, which is when the immune system does not recognise cells of the body as self and attacks healthy cells, causing destruction of otherwise normal tissue.  These include autoimmune diseases like Rheumatoid Arthritis, a chronic progressive disease of the joints in which inflammation causes joint destruction and deformity of the joints; and Systemic Lupus Erythematosus (SLE), a connective tissue disease that can affect many parts of the body like the skin, joints and many of the body’s organs and characterised by the deposition of autoantibodies.  Other autoimmune diseases that Imuran tablets 50mg are used for include Ulcerative Colitis and Crohn's Disease, which are chronic inflammatory bowel disorders; dermatomyositis and polymyositis, which are inflammatory diseases of the muscles causing muscle weakness; auto-immune chronic active hepatitis, which is when the normal liver cells are attacked by the immune system causing liver damage; pemphigus vulgaris, an autoimmune disease of the skin and mucous membranes causing blistering; polyarteritis nodosa, inflammation of the artery wall of small and medium arteries causing swelling and damage; auto-immune haemolytic anaemia, where red blood cells are targeted and destroyed resulting in insufficient numbers of oxygen carrying cells in the blood; chronic refractory idiopathic thrombocytopenic purpura, where the blood platelets are targeted and destroyed resulting in excessive bleeding and bruising.  Imuran tablets 50mg can be used as monotherapy alone or in combination with other drugs that influence the immune response such as corticosteroid medication, or where corticosteroid therapy cannot be tolerated or other treatments do not work, to dampen down the immune response and relieve symptoms of autoimmune disorders.

How does Imuran work?

Imuran tablets 50mg contain azathioprine an immunosuppressant antimetabolite used to prevent transplant rejection and treat a range of autoimmune disorders.  Azathioprine in Imuran tablets 50mg is a pro-drug of 6-mercaptopurine (6-MP), and is converted into 6-MP, which is a purine analogue that acts as an antimetabolite and inhibits nucleic acid synthesis.  Transplant rejection and autoimmune diseases are caused by destruction of normal cells by cells of the immune system due to proliferation and amplification of specific antibody producing cells.  These antibodies then target the healthy cells of the body (or transplant) and can be specific to a single tissue such as joints in rheumatoid arthritis, or the whole body as in the case of SLE.  If the match of the transplant is not close enough the immune system recognises the cells as non-self and in the case of autoimmune diseases the immune system mistakes normal cells of the body as foreign.  In both cases an immune response is initiated and cell destruction is the result.  Azathioprine in Imuran tablets 50mg, once converted to 6-MP, is incorporated into the nucleic acid of rapidly diving white blood cells of the immune system that promote the immune response.  This causes cell death of these immune cells which contributes to the immunosuppressive effects, and may take several weeks to become evident. 

What does Imuran contain?

Imuran tablets 50mg contains the active ingredient azathioprine, an immunosuppressant antimetabolite used to prevent transplant rejection and treat a range of autoimmune disorders.   They also include hypromellose, lactose, macrogol 400, magnesium stearate, maize starch, pregelatinised maize starch, stearic acid.

Treating autoimmune diseases with Imuran

Imuran tablets 50mg contain azathioprine an immunosuppressant antimetabolite used to treat a range of autoimmune disorders.  The main function of the immune system is to protect the body from invasion with harmful foreign bodies such as bacteria and viruses.  An autoimmune disease is when the body’s immune system attacks its own normal healthy cells.  This happens due to proliferation and amplification of specific antibody producing cells of the immune system.  These antibodies then target healthy cells of the body and can be directed against a single tissue type, such as the lining of the joints in rheumatoid arthritis, a chronic progressive disease of the joints in which inflammation causes joint destruction and deformity of the joints, or the whole body as in the case of systemic lupus erythematosus (SLE), a connective tissue disease that can affect many parts of the body like the skin, joints and many of the body’s organs.  Other autoimmune diseases that Imuran tablets 50mg are used to treat include, ulcerative colitis and Crohn's disease, which are chronic inflammatory bowel disorders; dermatomyositis and polymyositis, which are inflammatory diseases of the muscles causing muscle weakness; auto-immune chronic active hepatitis, which is when the normal liver cells are attacked by the immune system causing liver damage; pemphigus vulgaris, an autoimmune disease of the skin and mucous membranes causing blistering; polyarteritis nodosa, inflammation of the artery wall of small and medium arteries causing swelling and damage; auto-immune haemolytic anaemia, where red blood cells are targeted and destroyed resulting in insufficient numbers of oxygen carrying cells in the blood; chronic refractory idiopathic thrombocytopenic purpura, where the blood platelets are targeted and destroyed resulting in excessive bleeding and bruising.  Azathioprine in Imuran tablets 50mg is a pro-drug of 6-mercaptopurine (6-MP), and is converted into 6-MP, a purine analogue that is incorporated into the nucleic acid of rapidly diving white blood cells of the immune system that promote the immune response, inhibiting nucleic acid synthesis and causing cell death of these immune cells.  This contributes to the immunosuppressive effect of Imuran tablets 50mg, which may take several weeks to become evident. 

Imuran for preventing transplant rejection

Imuran tablets 50mg contain azathioprine an immunosuppressant antimetabolite used to prevent transplant rejection.  Organ transplantation is the final option for organ failure such as liver, heart or kidney, and involves tissue typing to ensure that the match between donor and recipient is close enough to prevent rejection.  This is genetically determined by the Major Histocompatibility Complex (MHC) that code for a group of genes known as the HLA (Human leucocyte antigen) system.  The system produces proteins that appear on the cell surface of all cells of the body and help the body’s immune system tell the difference between self and harmful foreign invaders like bacteria and viruses, which is the main function of the immune system.  If the transplanted organ is not a close enough match to the body’s own HLA antigens, the immune system attacks the healthy transplanted organ cells.  This happens due to proliferation and amplification of specific antibody producing cells of the immune system, which produce antibodies against the transplant and cell destruction is the result.  Azathioprine in Imuran tablets 50mg is a pro-drug of 6-mercaptopurine (6-MP), and is converted into 6-MP, a purine analogue that is incorporated into the nucleic acid of rapidly diving white blood cells of the immune system that promote the immune response and inhibits nucleic acid synthesis.  This causes cell death of these immune cells which blocks the body’s natural defence mechanism and contributes to the immunosuppressive effects of Imuran tablets 50mg, which may take several weeks to become evident. 

What are the side effects of Imuran?

The most commonly reported side effects when taking Imuran tablets 50mg include nausea, increased bleeding and bruising, increased risk of infection. 

When should Imuran not be used?

You should not use Imuran tablets 50mg if you:

  • are allergic to azathioprine or 6-mercaptopurine or any ingredients in Imuran
  • are pregnant or are breastfeeding
  • have kidney or liver disease
  • have chicken pox, shingles or Hepatitis B
  • have recently been or plan to be immunised with live vaccine, as azathioprine can affect the efficacy of the vaccine and cause infection
  • have Lesch-Nyhan syndrome (a deficiency in hypoxanthine- guanine-phosphoribosyltransferase causing overproduction of uric acid)
  • are taking medicines that interact with Imuran including allopurinol, oxipurinol or thiopurinol for gout, succinylcholine, used during anaesthesia, the anticoagulant warfarin, penicillamine for rheumatoid arthritis, the antibiotic co-trimoxazole, captopril for high blood pressure and heart failure, mesalazine, olsalazine or sulphasalazine for ulcerative colitis, methotrexate for cancer chemotherapy, the antiviral ribavirin for respiratory infection

What medications interact with Imuran?

Several medications interact with Imuran tablets 50mg and should either not be taken while you are taking Imuran or only after discussion and instruction from your doctor:

  • Drugs that cause a serious reaction with Imuran: penicillamine for rheumatoid arthritis, the antibiotic co-trimoxazole, captopril for high blood pressure and heart failure,
  • Drugs that affect Imuran: oxipurinol or thiopurinol for gout, mesalazine, olsalazine or sulphasalazine for ulcerative colitis, methotrexate for cancer chemotherapy, the antiviral ribavirin for respiratory infection
  • Drugs that are affected by Imuran: succinylcholine, used during anaesthesia, the anticoagulant warfarin

How should Imuran be taken?

You should take your Imuran tablets 50mg swallowed whole with a glass of water at least one hour before or three hours after food or milk.  The dose you take and for how long depends on what you are being treated for, how well you respond and your doctor’s recommendation.  You should continue to take your Imuran tablets 50mg for as long as recommended by your doctor which may be long term or indefinitely for preventing transplant rejection.

How long should you take Imuran?

You should continue to take your Imuran tablets 50mg for as long as recommended by your doctor which may be long term or indefinitely for preventing transplant rejection.

Missed dose of Imuran

If you miss a dose of Imuran tablets 50mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Imuran be stored?

You should store your Imuran tablets 50mg below 25°C in a cool dry place. 

 

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