Apo-Nadolol general information

What is Apo-Nadolol used for?

Apo-Nadolol tablets 40mg are used to treat a variety of conditions of the cardiovascular system. These include, control of mild to moderate hypertension (high blood pressure), alone as monotherapy or in combination with other antihypertensive agents, especially thiazide diuretics, to lower blood pressure and reduce the risk of complications such as stroke and heart attack. Apo-Nadolol tablets 40mg are also used for long-term management of angina (chest pain) in patients with heart disease; and control of most forms of arrhythmias (rapid or irregular heart beat). There is also some evidence that using Apo-Nadolol tablets 40mg long-term may help in the prevention of myocardial infarction (heart attack) and treatment of heart failure to improve survival and quality of life. Apo-Nadolol tablets 40mg are also used for preventing migraine, and to treat symptoms of hyperthyroidism (overactive thyroid) as well as preparing patients for thyroid surgery. Apo-Nadolol tablets 40mg work through a common mechanism in several different body systems to manage the condition and relieve symptoms by reducing heart rate (pulse), workload on the heart (force needed to pump) and oxygen demand by the heart, which increases blood flow and lowers blood pressure.

How does Apo-Nadolol work?

Apo-Nadolol tablets 40mg contain nadolol, a non-selective beta-blocker (also known as beta adrenergic antagonist), that binds to beta receptors found in vascular smooth muscle of blood vessel walls and several organs of the body, including the heart and lungs. Nadolol in Apo-Nadolol tablets 40mg blocks the action of chemicals called catecholamines, such as adrenaline (epinephrine) and noradrenaline (nor epinephrine), which are released by the adrenal glands in response to nerve stimulation during physical and mental stress. Adrenaline works binds to beta-receptors in the heart to stimulate increased heart rate and constriction (narrowing) of blood vessels. These actions of adrenaline are reduced or inhibited by nadolol in Apo-Nadolol tablets 40mg, to slow heart rate, dilate (widen) blood vessels, lower blood pressure, and increase blood flow and oxygen to the heart. When the heart beats more slowly and with less force, this reduces the pain associated with angina and frequency of angina attacks, also helps the heart beat to become more regular and reduces the force needed to pump blood around the body, which helps lower blood pressure. Since beta-receptors are found in many tissues, all short-term and long-term symptom relief due to taking Apo-Nadolol tablets 40mg, is based on blocking beta-receptors in the target tissue, for example, reducing symptoms associated with hyperthyroidism (overactive thyroid), including rapid heart rate, sweating and tremor. Although the mechanism by which Apo-Nadolol tablets 40mg help prevent migraine is not fully known, it is thought to involve prevention of vasoconstriction (blood vessel narrowing) of the internal carotid artery, by blocking beta receptors in the brain and prevention of excessive adrenergic vasodilation in the external carotid artery, which happens during a migraine attack. Apo-Nadolol tablets 40mg are formulated for controlled release so that nadolol is that released in a sustained and time controlled manner, to ensure a more even effect over 24 hours, which provides better symptom relief with fewer side effects.

What does Apo-Nadolol contain?

Apo-Nadolol tablets 40mg contain the active ingredient nadolol, a beta-blocker that is used to treat variety of conditions of the cardiovascular system and other conditions.

Treating high blood pressure (hypertension) with Apo-Nadolol

Apo-Nadolol tablets 40mg contain nadolol, a non-selective beta-blocker (also known as beta adrenergic antagonist), that binds to beta receptors that are found in vascular smooth muscle in blood vessel walls and several organs of the body, including the heart lungs and kidney. Nadolol in Apo-Nadolol tablets 40mg blocks the action of chemicals called catecholamines, such as adrenaline (epinephrine) and noradrenaline (nor epinephrine), which are released by the adrenal glands in response to nerve stimulation during physical and mental stress. Adrenaline binds to beta-receptors in the heart to stimulate increased heart rate and constriction (narrowing) of blood vessels. These actions of adrenaline are reduced or inhibited by nadolol in Apo-Nadolol tablets 40mg, to slow heart rate and dilate (widen) blood vessels, which prevents resistance to blood flow in peripheral blood vessels and increases blood flow and oxygen to the heart, which result in lower blood pressure. Lowering blood pressure using Nadolol tablets 40mg reduces the risk of complications such as stroke and heart attack, due to high blood pressure.

Treating heart disease with Apo-Nadolol

Apo-Nadolol tablets 40mg contain nadolol, a non-selective beta-blocker (also known as beta adrenergic antagonist), that that binds to beta receptors that are found in vascular smooth muscle in blood vessel walls and several organs of the body, including the heart lungs and kidney. Nadolol in Apo-Nadolol tablets 40mg and blocks the action of chemicals called catecholamines, such as adrenaline (epinephrine), which are released by the adrenal glands in response to nerve stimulation during physical and mental stress, with effects that slow heart rate, dilate (widen) blood vessels, lower blood pressure, and increase blood flow and oxygen to the heart. Apo-Nadolol tablets 40mg are used to treat a variety of conditions of the cardiovascular system to improve survival, reduce symptoms and improve the quality of life in patients with heart disease, including, control of hypertension (high blood pressure), management of angina (chest pain); long-term prevention of myocardial infarction (heart attack) and treatment of heart failure.

What are the side effects of Apo-Nadolol?

The most commonly reported side effects when taking Apo-Nadolol tablets 40mg include: bradycardia (slow heart beat), heart failure (shortness of breath on exertion), dizziness, gastrointestinal disturbances (diarrhoea, constipation, nausea, vomiting, abdominal pain), fatigue, sleepiness, bronchospasm, cold hands and feet (narrowing of the airways), headache.

When should Apo-Nadolol not be used?

You should not use Apo-Nadolol tablets 40mg if you:

• are allergic to nadolol or any ingredients in Apo-Nadolol
• are pregnant or are breastfeeding, without discussion with your doctor
• have a history of obstructive lung disorder, bronchial asthma or bronchospasm
• are diabetic and taking hypoglycaemic therapy, without discussion with your doctor as metoprolol may prolong the hypoglycaemic response to insulin
• have poor peripheral blood circulation, uncontrolled heart failure, low blood pressure (hypotension)
• have a phaeochromocytoma (a rare tumour of the adrenal gland) which is not already being treated with other medicines
• have certain other heart problems
• are taking medication that may interact with Apo-Nadolol, including: other medicines for high blood pressure; angina or an irregular heart beat such as calcium channel blockers (diltiazem, verapamil, and nifedipine), antiarrhythmics (disopyramide) digoxin, clonidine, hydralazine; other beta-blockers, including eye drops; the antibiotic rifampicin; adrenaline for emergencies like anaphylaxis; monoamine oxidase inhibitors; antiinflammatories like ibuprofen or indomethacin; cimetidine for reflux and ulcers; chlorpromazine for psychiatric disorders.

How should Apo-Nadolol be taken?

You should take your Apo-Nadolol tablets 40mg with a glass of water, once daily, with or without food. The dose of Apo-Nadolol tablets 40mg that you are taking depends on what you are being treated for and may be gradually increased by your doctor, depending on your condition and your response. You must take your tablets every day, as instructed and if you are advised to stop taking them, withdrawal should be gradual and treatment should not be discontinued abruptly.

How long should you take Apo-Nadolol?

You should take your Apo-Nadolol tablets 40mg for as long as your doctor recommendations, which may be for a few days, weeks, months or longer depending on the condition you are being treated for.

Missed dose of Apo-Nadolol

If you miss a dose of Apo-Nadolol tablets 40mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Apo-Nadolol be stored?

You should store your Apo-Nadolol below 30°C in a cool dry place, protected from light and moisture..