Catapres-TTS-2 4 Systems/Pack
Contains 4 Systems and 4 Adhesive Covers
Antihypertensive (alpha-2 adrenergic agonist)
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Catapres TTS general information
What is Catapres TTS used for?
Catapres TTS-2 (transdermal therapeutic system) is a transdermal delivery system or skin patch containing a medication used to help lower blood pressure in the treatment of mild to moderate hypertension. Although there are usually no other symptoms, essential hypertension, which is high blood pressure when at rest with usually no obvious and identifiable cause, increases risk of cardiovascular disease and if uncontrolled can cause kidney damage, stroke, heart attack and heart failure. Catapres TTS-2 can be used alone as monotherapy or in conjunction with other antihypertensive (blood pressure lowering) medication.
How does Catapres TTS work?
Catapres TTS-2 contains clonidine, an alpha-2 adrenergic agonist that acts primarily on the central nervous system by stimulating alpha-2 adrenergic receptors in the brain, which reduces activation of the sympathetic nervous system. This part of the nervous system controls functions that work without intervention of conscious thought, such as heart rate, narrowing of blood vessels (vasoconstriction) and blood pressure. The overall effect of alpha-2 adrenergic stimulation is to reduce blood pressure. Clonidine in Catapres TTS-2 is also thought to act directly on the peripheral blood vessels reducing the effect of vasoconstrictors (chemicals that cause blood vessels to contract and narrow) making them more relaxed and widened (vasodilation) and this reduces peripheral resistance to the action of blood pumping round the circulation, which also helps reduce blood pressure. Another result of the action of clonidine in Catapres TTS-2 is thought to be increased vagal tone, which is when only the parasympathetic nerve fibres (which have opposite functions to the sympathetic nerve fibres) carried by the vagus nerve, stimulate the heart to slow the heart rate, which also helps lower blood pressure. The combined action of Clonidine in Catapres TTS-2 reduces the force needed by the heart to pump blood around the body, reducing its workload and lowering blood pressure. Catapres TTS-2 (transdermal therapeutic system) is a transdermal delivery system or skin patch. When you apply the patch to your skin clonidine diffuses out of the patch through your skin and into your blood at a constant rate, delivering a dose of 0.2 mg per day over a period of a week.
What does Catapres TTS contain?
Catapres TTS-2 (transdermal therapeutic system) contains the active ingredient clonidine hydrochloride (5mg) that is released from a transdermal delivery system or skin patch at a constant rate of 0.2 mg/24 hours over a period of a week. The drug reservoir of clonidine also contains mineral oil, polyisobutylene and colloidal silicon dioxide. The skin patch comprises a backing layer of pigmented polyester film; a microporous polypropylene membrane that controls the rate of delivery of clonidine from the system to the skin surface.
Treating hypertension (high blood pressure) with Catapres TTS
Catapres TTS-2 contains clonidine, an alpha-2 adrenergic agonist that is used to help lower blood pressure in the treatment of mild to moderate hypertension. Although there are usually no other symptoms, hypertension, which is high blood pressure when at rest with usually no obvious and identifiable cause, increases risk of cardiovascular disease and if uncontrolled can cause kidney damage, stroke, heart attack and heart failure. Clonidine in Catapres TTS-2 acts primarily on the central nervous system by stimulating alpha-2 adrenergic receptors in the brain and this reduces blood pressure by reducing stimulation of the sympathetic nervous system (controls functions that work without intervention of conscious thought), as well as causing peripheral blood vessels to relax and widen, and acting directly on the heart to slow down the heart rate. The combined actions of Catapres TTS-2 reduces resistance of peripheral blood vessels and the force needed by the heart to pump blood around the body, which in turn reduces the workload on the heart and lowers blood pressure. Reducing blood pressure reduces the risk of cardiovascular disease, including stroke and heart attack.
What Catapres TTS doses are available?
Catapres TTS patches are available in 2 strengths, each in packs of 4 patches.
- Catapres TTS-2 contains 5mg clonidine in each patch and releases 0.2mg clonidine into your blood per day
- Catapres TTS-3 contains 7.5mg clonidine in each patch and releases 0.3mg clonidine into your blood per day
What are the side effects of Catapres TTS?
The most commonly reported side effects when using Catapres TTS include: drowsiness, dry mouth and local skin reactions. Less common side effects are usually associated with oral clonidine tablets and include constipation, sleep disturbances, erectile dysfunction, orthostatic hypotension (light-headedness when you stand up suddenly), dizziness. Skin reactions can include non-allergic irritation and allergic contact dermatitis, with symptoms including: reddening of the skin under the patch, itching and in severe cases, swelling and vesiculation.
When should Catapres TTS not be used?
You should not use Catapres TTS-2 if you:
- are allergic to clonidine or any ingredients in Catapres TTS
- are pregnant or are breastfeeding
- have kidney disease
- have certain heart problems, such as irregular/slow heart beat (bradyarrhythmia)
- hypertension caused by phaeochromocytoma (a rare tumour of the adrenal gland)
- are taking medicines that interact with Catapres TTS: including other antihypertensive agents such as diuretics, vasodilators, beta-receptor blockers, calcium antagonists and ACE-inhibitors, non steroidal anti inflammatory agents, the vasodilator tolazoline, digoxin for various heart conditions like heart failure, mirtazapine for depression, beta-receptor blockers for various heart conditions and hypertension, tricyclic anti-depressants, neuroleptics antipsychotics, alcohol
What medications interact with Catapres TTS?
Several medications interact with Catapres TTS and should either not be taken while you are taking Catapres TTS or only after discussion and instruction from your doctor:
- Drugs that cause a serious reaction with Catapres TTS: digoxin for various heart conditions like heart failure, beta-receptor blockers for various heart conditions and hypertension, alcohol
- Drugs that affect Catapres TTS: other antihypertensive agents such as diuretics, vasodilators, beta-receptor blockers, calcium antagonists and ACE-inhibitors, non steroidal anti inflammatory agents, the vasodilator tolazoline, mirtazapine for depression, neuroleptics antipsychotics
How should Catapres TTS be used?
You should apply your Catapres TTS patch once a week after removing the old patch and only one patch should be worn at any time. You can use Catapres TTS patches continually and the dose you use depends on your condition, how well you respond and your doctor’s recommendation. Before you apply your patch, make sure your skin is clean and dry and is not oily, cut or irritated and choose an area of skin with little or no hair, such as upper arm or chest. Leave the patch on even in the shower or bath or when swimming. If the patch becomes loose, cover it with the extra adhesive overlay provided, but if it becomes too loose or falls off apply a new one. When you change your patch at the end of the week apply the next patch to a different part of your body as you should not use the same area of skin twice running. You should continue to use your Catapres TTS patches for as long as your doctor recommends, as they will help reduce your blood pressure but will not cure your hypertension.
How long should you take Catapres TTS?
You should continue to use your Catapres TTS patches for as long as your doctor recommends, as they will help reduce your blood pressure but will not cure your hypertension.
Missed dose of Catapres TTS
If you miss a dose of Catapres TTS by forgetting to change your patch, change it as soon as you remember. If it is more than 3 days, check with your doctor as your blood pressure may begin to rise.
How should Catapres TTS be stored?
You should store your Catapres TTS below 25°C in a cool dry place.