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Lopimune 200/50mg 60 Tablets/Pack


Lopimune 200/50mg 60 Tablets/Pack

Lopimune 200mg (Lopinavir)

 

Product Name
Lopimune 200/50mg 60 Tablets/Pack
Also known as Kaletra
Active Ingredient
Lopinavir and Ritonavir
Manufacturer
Cipla Pharmaceuticals
Product Type
Antiretroviral (HIV protease inhibitor)
Product expiry date we are currently shipping
Feb 2020
Product Price List
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Lopimune (Lopinavir/Ritonavair) 200mg/50mg 60 Tablets
$2.10 per Tablet
|
$126.00 (USD) 
$126.00 (USD) 
Lopimune (Lopinavir/Ritonavair) 200mg/50mg 120 Tablets
$1.90 per Tablet
|
$228.00 (USD) 
$228.00 (USD) 
Lopimune (Lopinavir/Ritonavair) 200mg/50mg 180 Tablets
$1.80 per Tablet
|
$324.00 (USD) 
$324.00 (USD) 
Lopimune tablets 200/50mg contain a fixed dose combination of two antiretroviral drugs lopinavir and ritonavir, which are used to treat HIV infection.

Lopimune general information

What is Lopimune used for?

Lopimune tablets 200/50mg are a fixed dose combination treatment for Human Immunodeficiency Virus (HIV) infection in adults over and children over 6 months. Lopimune tablets200/50mg are used in combination with other medications that have a different mechanism of action to the components in Lopimune, and are used to treat patients with HIV infection who have either already received treatment with other medications for HIV or as first line therapy for treatment-inexperienced patients. HIV impairs the immune system by attacking specific immune cells called CD4+ cells that are involved in fighting infection and this can lead to opportunistic life-threatening infection (infections that would not normally be harmful); also if too many CD4+ cells are destroyed this can result in acquired immune deficiency syndrome (AIDS). Lopimune tablets prevent or slow down the ability of HIV to replicate and spread, which keeps the amount virus down to a low level and this results in an increase in CD4+ cell numbers, so that the immune system can recover, reducing the risk of disease progression.

How does Lopimune work?

Lopimune tablets 200/50mg contain lopinavir and ritonavir, which are both inhibitors of HIV protease and are only effective against RNA viruses (retroviruses) like Human Immunodeficiency Virus (HIV). Retroviruses convert RNA to DNA, by the action of the viral-specific enzyme reverse transcriptase (RT). The viral DNA is then integrated into the DNA of infected immune cells so that the virus can replicate. Most of the antiviral activity of Lopimune is due to lopinavir, which is a potent inhibitor of HIV protease, and prevents cleavage of the Gag-Pol polyprotein, an important protein in the development of active virus. The viral protease enzyme cleaves (breaks down) the Gag-Pol polyprotein during final stages of the replication cycle so that fully active mature virus can be released to infect new cells. Inhibition of protease cleavage by Lopimune results in the production of immature, non-infectious viral particles. Ritonavir in Lopimune tablets 200/50mg is included in the combination not as a protease inhibitor but because it inhibits the CYP3A-mediated metabolism (breakdown in the liver) of lopinavir, thereby increasing the plasma levels of lopinavir so that lopinavir can be used at a lower dose. Lopimune tablets are used in combination with other retrovirals that have a different mechanism of action, like emtricitabine and tenofovir, both nucleoside reverse transcriptase inhibitor (NRTI) that work by blocking the action of RT, inhibiting viral replication. The combined action of lopinavir and ritonavir in Lopimune tablets 200/50mg, in conjunction with other retroviral drugs, inhibits the production of active HIV so that the viral load (amount of virus) is reduced. Lopimune tablets slow down the replication of HIV within your body but does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others.

What does Lopimune contain?

Lopimune tablets 200/50mg contain a combination of the active ingredients lopinavir (200mg) and ritonavir (50mg), which are antiretroviral drugs that are used to treat HIV infection by inhibition of HIV protease.

Treating HIV infection with Lopimune

Lopimune tablets 200/50mg contain a combination of lopinavir and ritonavir, which are both inhibitors of HIV protease and are antiretroviral drugs used to treat HIV infection in adults and children over 6 months. HIV impairs the immune system by attacking specific immune cells called CD4+ cells that are involved in fighting infection, and this can lead to opportunistic life-threatening infection (infections that would not normally be harmful), including pneumonia, herpes virus infections, and Mycobacterium avium complex (MAC) infection. If too many CD4+ cells are destroyed this can result in acquired immune deficiency syndrome (AIDS). Lopinavir in Lopimune tablets 200/50mg is a potent inhibitor of HIV protease, and prevents cleavage of the Gag-Pol polyprotein, an important protein in the development of active virus. The viral protease enzyme cleaves (breaks down) the Gag-Pol polyprotein during final stages of the replication cycle so that fully active mature virus can be released to infect new cells. Inhibition of protease cleavage by Lopimune results in the production of immature, non-infectious viral particles. Ritonavir in Lopimune tablets 200/50mg is also a protease inhibitor but its main function is to inhibit the CYP3A-mediated metabolism (breakdown in the liver) of lopinavir, thereby increasing the plasma levels of lopinavir so that it can be used at a lower dose. The combined action of lopinavir and ritonavir in Lopimune tablets inhibits the production of active HIV so that the viral load (amount of virus) is reduced. Lopimune tablets are used in combination with other retroviral drugs that work by a different mechanism to slow down the replication of HIV within your body although it does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others.

What are the health risks when taking Lopimune

Pancreatitis is a serious and potentially fatal condition that has been reported when taking Lopimune tablets200/50mg. Symptoms begin within a few months of treatment and include: nausea, vomiting and abdominal pain; also abnormal laboratory results. Lopimune has also been reported to increase blood glucose levels, which increases risk for diabetes. In some cases PR Interval Prolongation has been reported which increases risk of heart problems like atrial fibrillation and heart attack.

What are the side effects of Lopimune?

The most commonly reported side effects when taking Lopimune tablets 200/50mg include: mild to moderate diarrhoea; increased blood cholesterol and triglycerides, which may be a risk factor for pancreatitis; increased liver enzymes such as gamma-glutamyltransferase (GGT); redistribution of body fat from the arms, legs and face to the abdominal region; inflammation reaction due to immune reconstitution syndrome as the immune system recovers and fights infection caused by residual infection.

When should Lopimune not be used?

You should not use Lopimune tablets200/50mg if you:
  • are allergic to lopinavir and ritonavir or any ingredients in Lopimune
  • are pregnant or are breastfeeding
  • have a particular heart condition called long QT syndrome, underlying structural heart disease, preexisting conduction system abnormalities, ischemic heart disease or cardiomyopathies
  • have severe liver disease like hepatitis or cirrhosis
  • have the blood condition haemophilia, without discussion with your doctor as Lopimune can cause increased bleeding
  • are taking medicines that interact with Lopimune, including: other retrovirals like zidovudine and saquinavir, antiarrhythmics like amiodarone, anticancer agents like vincristine, the anticoagulant warfarin, anticonvulsants like carbamazepine, analgesics like fentanyl, digoxin for heart failure, the antidepressants trazodone and bupropion, anticonvulsants like phenytoin and carbamazepine, antifungals like ketoconazole, the antibiotics clarithromycin and rifampicin, benzodiazepines like midazolam, calcium channel blockers like nifedipine, corticosteroids like dexamethasone, the antipsychotic blonanserin, PDE5 inhibitors like sildenafil for erectile dysfunction, statin drugs atorvastatin like for high cholesterol, salmeterol for asthma, contraceptives like ethinyl estradiol, ergot drugs like ergotamine for migraine headaches, the herbal product St Johns wort, cisapride for gastric reflux, the antipsychotic pimozide

What medications interact with Lopimune?

Several medications interact with Lopimune 200/50mg and should either not be taken while you are taking Lopimune or only after discussion and instruction from your doctor:
  • Drugs that cause a serious reaction with Lopimune: benzodiazepines like midazolam, PDE5 inhibitors like sildenafil for erectile dysfunction, statin drugs atorvastatin like for high cholesterol, salmeterol for asthma, ergot drugs like ergotamine for migraine headaches, cisapride for gastric reflux, the antipsychotic pimozide
  • Drugs that affect Lopimune: anticonvulsants like phenytoin and carbamazepine, the antibiotic rifampicin, corticosteroids like dexamethasone, the herbal product St Johns wort,
  • Drugs that are affected by Lopimune: other retrovirals like zidovudine and saquinavir, antiarrhythmics like amiodarone, anticancer agents like vincristine, the anticoagulant warfarin, anticonvulsants like carbamazepine, analgesics like fentanyl, digoxin for heart failure, the antidepressants trazodone and bupropion, anticonvulsants like phenytoin and carbamazepine, antifungals like ketoconazole, the antibiotic clarithromycin, benzodiazepines like midazolam, calcium channel blockers like nifedipine, the antipsychotic blonanserin, PDE5 inhibitors like sildenafil for erectile dysfunction, statin drugs atorvastatin like for high cholesterol, salmeterol for asthma, contraceptives like ethinyl estradiol

How should Lopimune be taken?

You should take your Lopimune tablets 200/50mg whole with a glass of water with or without food, once or twice daily depending on your condition, whether you have taken, or are currently taking other antiretroviral drugs and your doctor’s recommendation. Your dose may be increased or decreased depending on how well you respond and whether you have any reactions or side effects. For children the dose should be calculated based on body weight (kg) or body surface area (BSA) and should not exceed the recommended adult dose. You should continue to take your Lopimune tablets 200/50mg regularly for as long as your doctor recommends as it helps control the HIV infection but does not cure it; do not stop taking your tablets even if you feel better without discussion with your doctor.

How long should you take Lopimune?

You should continue to take your Lopimune tablets 200/50mg regularly for as long as your doctor recommends as it helps control the HIV infection but does not cure it; do not stop taking your tablets even if you feel better without discussion with your doctor.

Missed dose of Lopimune

If you miss a dose of Lopimune tablets 200/50mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Lopimune be stored?

You should store your Lopimune tablets 200/50mg below 30°C in a cool dry place.



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