Domperon 10 (Domperidone)

Domperon General Information

What is Domperon used for?

Domperon 10 is used to treat nausea and vomiting and help relieve symptoms like bloating, fullness, heartburn and flatulence that cause discomfort when the digestive system is out of rhythm or you have eaten too much. Domperon 10 can also be used to relieve symptoms of nausea caused by some medications, such as anti-cancer drugs and medications used for Parkinson’s disease. Another use for Domperon is to increase breast milk production, as a side effect of its intended use.

How does Domperon work?

Domperon 10 contains domperidone, a dopamine antagonist that acts as an antiemetic (prevents nausea and vomiting) and as a gastrokinetic (stimulates gastrointestinal mobility). Nausea and vomiting are triggered when the chemoreceptor trigger zone (CTZ) in the brain is stimulated, and this causes nerve impulses to be sent to area postrema or vomiting centre of the brain, to induce the vomiting reflex. The CTZ can be activated by two mechanisms; either indirectly by transmission of nerve impulses sent to the brain from the stomach when it has been irritated, or directly by chemicals or drugs that are circulating in the blood and stimulate receptors in the brain. Domperon 10 works by blocking the action of the chemical messenger dopamine and this stops the transmission of messages from the irritated or upset stomach to the brain, preventing the brain triggering the vomiting response. Domperon 10 also blocks the same chemical messengers in the upper digestive system. This relieves dysmobility, which is when food processing slows down causing uncomfortable symptoms. Domperon 10 restores the natural rhythm of muscle contraction and relaxation in the stomach, which helps push food through the digestive system and prevents vomiting.

What does Domperon contain?

Domperon tablets 10mg contain the active ingredient domperidone, an antiemetic used to relieve nausea and vomiting.
Inactive ingredients: Aspartame, polycarboxylic acid potassium, pearlitol-granular mannitol, sunset yellow lake, starch, colloidal silicon dioxide, sodium starch glycollate, orange flavour and magnesium stearate.

Treating nausea and vomiting with Domperon

Domperon tablets 10mg contain domperidone, a dopamine antagonist that is used as antiemetic (prevents nausea and vomiting) to treat nausea and vomiting caused by a variety of conditions, including, gastrointestinal disorders or medication such as anti-cancer drugs. Domperon 10 works by blocking the action of the chemical messenger dopamine in the brain and in the upper intestine, and this prevents vomiting and restores the natural rhythm of the digestive system. The action of Domperon 10 helps relieve symptoms of digestive problems including bloating, fullness, heartburn, regurgitation of bile, abdominal pain and flatulence, which can happen when the digestive system is out of rhythm and cause discomfort.

How does Domperon help with breastfeeding?

If you are having trouble producing enough breast milk you can use Domperon to help with breastfeeding. Domperidone 10mg, the active ingredient of Domperon, increases blood levels of the hormone prolactin, which stimulates milk production in a new mother’s breast cells. This is an indirect result of blocking the chemical messenger dopamine, which is also how Domperon prevents nausea and vomiting. Domperon does pass from the blood into breast milk, however, it is present in small amounts and there is no indication that it will harm the baby. Domperon has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production.

Domperon for increasing breast milk production

Domperon can be used to increase breast milk production as it has been found to increase blood levels of the hormone prolactin, which stimulates milk production in a new mother’s breast cells. This is an indirect result of blocking the chemical messenger dopamine, which is also how Domperon prevents nausea and vomiting. Domperon 10 does pass from the blood into your breast milk, however, it is present in small amounts and there is no indication that it will harm the baby. Domperon has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production.

What are the side effects of Domperon?

The most commonly reported side effects when taking Domperon 10 include: headache, abdominal cramps and dry mouth. Because Domperon does not cross the blood brain barrier it does not cause what are known as extrapyramidal side effects, like convulsion and involuntary muscle actions that can be associated with some dopamine blocking medications. However, for the same reason Domperon can increase the production of the hormone prolactin, which stimulates breast milk secretion, and this can cause breast enlargement (gynaecomastia) and temporary stoppage of periods (amenorrhoea). These side effects will stop as soon as you stop taking Domperon.

When should Domperon not be used?

You should not use Domperon 10 if you:

• are allergic to to domperidone or any of the other components in Domperon 10
• have an intolerance to lactose, a lactose malabsorption or a genetic disorder leading to accumulation of galactose in the blood (galactosaemia), as lactose is used to coat the tablets
• have a condition where increasing gut motility could be harmful, such as gastrointestinal haemorrhage, mechanical obstruction or a perforation
• have a kidney or liver condition than causes impairment of renal or hepatic function
• have a pituitary tumour that causes over-production of prolactin (prolactinoma)
• are taking another medication that may interact with Domperon and prevent one or both drugs working effectively, such as the antifungals ketoconazole, fluconazole or voriconazole, antibiotics containing erythromycin, clarithromycin or telithromycin; amiodarone for rapid heart beat.

How should Domperon be taken?

You should take Domperon tablets 10mg with a glass of water 15 to 30 minutes before meals. If you are over 16, you can take a tablet three times a day and at bedtime, if necessary, but no more than four tablets in 24 hours. You should continue to take Domperon 10 for as long as recommended by your doctor.

How long should you take Domperon?

You should continue to take Domperon 10 for as long as recommended by your doctor.

Missed dose of Domperon

If you miss a dose of Domperon 10, take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Domperon be stored?

You should store your Domperon tablets 10mg below 30°C in a cool dry place and protect from light.