Duova Rotacaps

Duova Rotacaps general information

What is Duova Rotacaps used for?

Duova Rotacaps contain a combination treatment used for the long-term maintenance treatment of chronic obstructive pulmonary disease (COPD), which is a progressive obstructive airways disease that usually gets worse with time. COPD has symptoms similar to asthma caused by bronchospasm, including tightness of the chest, wheezing and shortness of breath, as well as chronic cough with sputum production because the lung tissues have become damaged. Duova Rotacaps provides improved action to open airways and improve breathing, which helps relieve symptoms, where a single medication has not been sufficiently effective.

How does Duova Rotacaps work?

Duova Rotacaps contains two bronchodlators that are used for long-term treatment chronic obstructive pulmonary disease (COPD). Formoterol in Duova Rotacaps is a potent, selective, long-acting beta-agonist that acts locally in the lungs and works as a bronchodilator by relaxing the smooth muscle in the airway walls to widen the airways. Tiotropium in Duova Rotacaps is a long-acting anticholinergic that acts on specific receptors (muscarinic receptors) in the bronchioles of the lung and inhibits the interaction of acetylcholine (a neurotransmitter or chemical messenger of the nervous system) with muscarinic receptors, which prevents spasm of the airway wall caused by acetylcholine. The synergistic action (interacting to enhance the action of each other) of the two drugs working together by different mechanisms, reduces bronchospasm (contraction of the airways) to a greater extent than would be provided by each drug alone and increases air flow into the lungs, relieving symptoms of COPD such as chronic cough with sputum production, tightness of the chest, wheezing and shortness of breath.

What do Duova Rotacaps contain?

Duova Rotacaps are inhalation capsules that contain a dry powder with a combination of two active ingredients;formoterol fumarate dihydrate (12mcg), a long-acting beta-agonist, and tiotropium bromide monohydrate (18mcg) a long-acting anticholinergic used to treat chronic obstructive pulmonary disease (COPD).

Treating chronic obstructive pulmonary disease (COPD) with Duova Rotacaps

Duova Rotacaps contains two bronchodlators, formoterol and tiotropium that are used in combination for long-term treatment of chronic obstructive pulmonary disease (COPD). Formoterol and tiotropium in Duova Rotacaps work synergistically by different mechanisms, to relax the muscles of the airways, reducing bronchospasm (narrowing of the airways) and increasing air flow into the lungs. Formoterol is a potent, selective, long-acting beta-agonist that acts locally in the lungs and works as a bronchodilator by relaxing the smooth muscle in the airway walls to widen the airways. Tiotropium is a long-acting anticholinergic that acts on specific receptors (muscarinic receptors) in the bronchioles of the lung and inhibits the interaction of acetylcholine (a neurotransmitter or chemical messenger of the nervous system) with muscarinic receptors, which prevents spasm of the airway wall caused by acetylcholine. Chronic obstructive pulmonary disease (COPD) is a progressive obstructive airways disease that usually gets worse with time, with symptoms similar to asthma caused by bronchospasm, including tightness of the chest, wheezing and shortness of breath, as well as chronic cough with sputum production because the lung tissues have become damaged. Duova Rotacaps provides improved action to open airways and improve breathing, which helps relieve symptoms, where a single medication has not been sufficiently effective.

What are the side effects of Duova Rotacaps?

The most commonly reported side effects when taking Duova Rotacaps include: dry mouth and throat, cough, rapid heartbeat (tachycardia), blurred vision, high pressure in the eye (glaucoma), oral candida (thrush), dizziness, nausea, constipation, upset stomach, stuffy nose, dysphonia (hoarse voice), sinusitis, viral Infection, bronchitis, chest pain, tremors, dizziness, insomnia, tonsillitis, rash. Paradoxical bronchospasm is uncommon but can occur in which your Rotacaps worsens your breathing. Also hypokalaemia (low blood potassium) is an uncommon but serious side effect.

When should Duova Rotacaps not be used?

You should not use Duova Rotacaps if you:

• are allergic to atropine or its derivatives like ipratropium, tiotropium, formoterol, or any ingredients in Duova Rotacaps
• are pregnant or are breastfeeding
• have kidney disease
• are having an acute episode of bronchospasm, as Duova is not intended for rescue therapy
• have glaucoma, urinary problems, irregular heartbeat, or prostate or kidney disease
• have any of the following condition without discussion with your doctor: heart disease, high blood pressure, or congestive heart failure, epilepsy, diabetes, overactive thyroid
• are taking medicines that interact with Duova Rotacaps, including: other beta-agonists like pseudoephidrine in cold medications, beta-blockers like atenolol, MAOIs like phenelzine, tricyclic antidepressants (TCAs) like amitriptyline, diuretics like furosemide or hydrochlorothiazide

What medications interact with Duova Rotacaps?

Several medications interact with Duova Rotacaps and should either not be taken while you are taking Duova Rotacaps or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with Duova Rotacaps: anticholinergics like atropine, other beta-agonists like pseudoephidrine in cold medications, diuretics like furosemide or hydrochlorothiazide
• Drugs that affect Duova Rotacaps: beta-blockers like atenolol
• Drugs that are affected by Duova Rotacaps: beta-blockers like atenolol

How should Duova Rotacaps be taken?

You should use your Duova Rotacaps as recommended by your doctor, usually one inhalation capsule once daily. The inhalation capsules should not be swallowed and the dry powder contents should be inhaled using the rotahaler/revolizer as recommended by the manufacturer. You should continue to use your Duova Rotacaps continually for as long as your doctor recommends. You should not stop taking your Duova Rotacaps, even if you feel better.

How long should you take Duova Rotacaps?

You should continue to use your Duova Rotacaps continually for as long as your doctor recommends. You should not stop taking your Duova Rotacaps, even if you feel better.

Missed dose of Duova Rotacaps

If you miss a dose of Duova Rotacaps take it as soon as you remember, unless it is time to take the next dose, then skip the missed d@ose. Do not take a double dose.
How should Duova Rotacaps be stored?
You should store your Duova Rotacaps below 25°C in a cool dry place.