Motilium (Domperidone 10mg) (Sourced from Turkey)

Motilium general information

What is Motilium used for?

Motilium tablets 10mg are used to treat acute nausea and vomiting to prevent vomiting and relieve symptoms of nausea.  Motilium 10 is also used to help relieve symptoms of dyspepsia, like bloating, fullness, heartburn, flatulence and abdominal pain or discomfort when the digestive system is out of rhythm.  This can be due to gastroparesis, which is delayed emptying of the stomach caused by slowing down or paralysis of normal muscular muscle contractions as a result of altered eating patterns or some medical conditions; or dysmobility, which is when food processing slows down due to slowing down of the muscular contractions of the small intestine.  Another use for Motilium tablets 10mg is to increase breast milk production, as a side effect of its intended use.

How does Motilium work?

Motilium tablets 10mg contain domperidone an antiemetic and prokinetic that is used to relieve symptoms of nausea, vomiting and dyspepsia.  Domperidone in Motilium tablets 10mg works by blocking receptors for the chemical messenger dopamine in the chemoreceptor trigger zone in the area postrema, which is outside the blood‐brain barrier and is where the vomit response is triggered.  This action of domperidone in Motilium 10 stops messages sent from the irritated or upset stomach being received by the chemoreceptor trigger zone, preventing the brain triggering the vomiting response and relieving symptoms of feeling queasy and nauseous.  Motilium 10 also blocks dopamine receptors in the upper digestive system, which increases contractions of the stomach and intestines, allowing food to move more easily through the stomach.  This action of domperidone in Motilium 10 restores the natural rhythm of muscle contraction and relaxation in the stomach, which helps push food through the digestive system.  Motilium tablets 10mg work through the same mechanism to prevent nausea and vomiting and also to relieve symptoms of dyspepsia and gastroparesis. 

What does Motilium contain?

Motilium tablets 10mg contains the active ingredient domperidone an antiemetic and prokinetic that is used to relieve symptoms of nausea, vomiting and dyspepsia.  They also contain lactose, maize starch, microcrystalline cellulose, pregelatinized potato starch, povidone, magnesium stearate, hydrogenated cottonseed oil, sodium lauryl sulfate and hypromellose.

Treating nausea, vomiting and dyspepsia with Motilium

Motilium tablets 10mg contains domperidone an antiemetic and prokinetic that is used to relieve symptoms of acute nausea and vomiting; also dyspepsia due to gastroparesis, which is delayed emptying of the stomach, or dysmobility, which is when food processing slows down.  Motilium 10 relieves symptoms, like bloating, fullness, heartburn, flatulence and abdominal pain or discomfort when the digestive system is out of rhythm.  Domperidone in Motilium tablets 10mg works by blocking receptors for the chemical messenger dopamine in the chemoreceptor trigger zone, the area of the brain that triggers the vomiting response, which prevents messages sent from the irritated or upset stomach being received by the chemoreceptor trigger zone and relieving symptoms of feeling queasy and nauseous and preventing vomiting.  Domperidone in Motilium 10 also blocks dopamine receptors in the upper digestive system, which increases contractions of the stomach and intestines, allowing food to move more easily through the stomach.  This action of domperidone in Motilium 10 restores the natural rhythm of muscle contraction and relaxation in the stomach and intestines, which helps push food through the digestive system and relieves symptoms of nausea and dyspepsia. 

Motilium for increasing breast milk production

Motilium tablets 10mg contains domperidone an antiemetic and prokinetic that can also be used to increase breast milk production as a side effect of its actions, for women who are having trouble producing enough breast milk.  Domperidone in Motilium tablets 10mg increases blood levels of the hormone prolactin, which stimulates milk production in a new mother’s breast cells.  This is an indirect result of blocking the action of the chemical messenger dopamine, which is also how Motilium 10 prevents nausea and vomiting.  Motilium does pass from the blood into breast milk, however, it is present in small amounts and there is no indication that it will harm the baby.  Domperidone in Motilium tablets 10mg has fewer side effects than metoclopramide, which is another medication used for stomach problems that also stimulates milk production. 

What are the side effects of Motilium?

The most commonly reported side effects when taking Motilium include headache, abdominal cramps and dry mouth.  Because domperidone in Motilium tablets 10mg does not cross the blood brain barrier it does not cause what are known as extrapyramidal side effects, like convulsion and involuntary muscle actions that can be associated with some dopamine blocking medications.  However, for the same reason Motilium can increase the production of the hormone prolactin, which stimulates breast milk secretion, and this can cause breast enlargement (gynaecomastia) and temporary stoppage of periods (amenorrhoea).  These side effects are temporary will stop as soon as you stop taking Motilium 10.

When should Motilium not be used?

You should not use Motilium tablets 10mg if you:

• are allergic to domperidone or any ingredients in Motilium
• have an intolerance to lactose, a lactose malabsorption or a genetic disorder leading to accumulation of galactose in the blood (galactosaemia), as lactose is used to coat the tablets
• have kidney or liver disease
• have a condition where increasing gut motility could be harmful, such as gastrointestinal haemorrhage, mechanical obstruction or a perforation
• have a pituitary tumour that causes over-production of prolactin (prolactinoma).
• are taking medicines that interact with Motilium increasing the concentration of domperidone, including the antifungal ketoconazole, fluconazole or voriconazole, antibiotic containing erythromycin, clarithromycin or telithromycin, the antiarrhythmic amiodarone, ritonavir, saquinavir, telaprevir for HIV

How should Motilium be taken?

You should take your Motilium tablets 10mg swallowed whole with a glass of water 15 to 30 minutes before meals three times daily and again at bedtime, if necessary, but no more than four tablets in 24 hours.  Motilium 10 is not intended for long-term use and you should not continue to take your Motilium tablets 10mg for more than two weeks, unless recommended by your doctor.

How long should you take Motilium?

Motilium 10 is not intended for long-term use and you should not continue to take your Motilium tablets 10mg for more than two weeks, unless recommended by your doctor.

Missed dose of Motilium

If you miss a dose of Motilium tablets 10mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Motilium be stored?

You should store your Motilium below 25°C in a cool dry place.