APO-Diltiazem CD 180mg

APO-Diltiazem CD capsules 180mg contain diltiazem, a calcium channel blocker that is used to treat chronic stable angina and hypertension.

APO-Diltiazem CD general information

What is APO-Diltiazem CD used for?

Cardiovascular disease covers a range of heart and circulation problems, including hypertension (high blood pressure), heart failure and angina.  Coronary artery disease (CAD) is the most common form of heart disease.  It is the narrowing of blood vessels that supply the heart due to clogged arteries.  Angina is a symptom of CAD, and if it gets worse, CAD can result in a heart attack.  If CAD is not treated, this can lead to heart failure, where the heart muscle becomes weakened and cannot pump efficiently.  APO-Diltiazem CD capsules 180mg are used for long-term treatment of angina that has persisted for some time.  They are also used to treat mild to moderate hypertension, in conjunction with other antihypertensive medicines like diuretics (water pills).

What is angina?

Narrowing of the arteries is also known as atherosclerosis.  It is caused by a build-up of plaque, which is fatty deposits, mainly cholesterol.  Clogged arteries restrict blood flow to the heart, and the heart muscle becomes starved of oxygen.  However, because the arteries are not blocked completely, it does not cause permanent damage to the heart.  Angina pectoris is one of the first signs that your heart is not getting enough oxygen.  The symptoms of angina include chest pain, tightness or heaviness across the chest, and a feeling of discomfort like indigestion.  If this continues, the condition is known as chronic stable angina, and symptoms can be triggered by any form of exertion or emotional stress.  This condition is a warning sign that you are at increased risk of a more serious heart problem such as heart attack.  Coronary artery spasm is a sudden tightening of the muscles in the artery wall, which temporarily cuts off the blood supply to your heart.  Coronary artery spasm causes angina symptoms but does not last long.  APO-Diltiazem CD capsules 180mg relieve symptoms of chronic stable angina and angina caused by coronary artery spasm, and to prevent the condition from getting worse.  APO-Diltiazem is not suitable for treating unstable or acute angina, which is when symptoms can develop when you are at rest, and they usually last for longer.

High blood pressure

Blood pressure is the force of your heart pumping blood around the body, combined with the resistance of the artery walls to the blood, as it is pumped through the circulation.  Two blood pressure measurements indicate whether your blood pressure is within the normal range.  Systolic pressure measures the force generated by the heart contracting with each heartbeat as it pumps blood out into the arteries.  Diastolic pressure is the resting phase between each heartbeat when the heart muscle relaxes, and the heart fills with blood.  When your blood pressure is measured, it is expressed as systolic pressure (the highest measure) over diastolic pressure (the lowest measure). 

If the arteries become narrowed or constricted, this increases their resistance to blood flow, and more force is needed to pump blood around the body.  The extra strength of the blood against artery walls due to narrowing causes systemic hypertension, which is high blood pressure when your body is relaxed and at rest.  High blood pressure puts a strain on the heart by increasing its workload and its need for more oxygen.  The extra force of blood in the circulation can damage blood vessels, especially smaller blood vessels, such as those in the kidneys, which can lead to kidney damage.  Hypertension also increases the risk of cardiovascular disease, including stroke and heart attack.  There are usually no symptoms of hypertension, so you will only know if you have high blood pressure by having a check. 

How does APO-Diltiazem CD work?

APO-Diltiazem CD capsules 180mg contain diltiazem, a calcium channel blocker that is used to treat chronic stable angina and mild to moderate hypertension. 

Calcium is needed for contraction of smooth muscle in artery walls (vasoconstriction) and also the heart muscle (myocardium).  Diltiazem in APO-Diltiazem CD capsules 180mg works by inhibiting calcium ions flowing into smooth muscle cells across specific calcium channels in their cell membranes.  If these calcium channels are blocked, the smooth muscle cells cannot contract as strongly, which allows arteries to relax and widen (vasodilation). 

Widening of the main arteries of the heart increases the oxygen supply to the heart, which reduces the heart’s workload and demand for oxygen.  As the heart recovers its oxygen supply, the heart rate and systemic blood pressure are also reduced.  Increasing the oxygen supply to the heart means that the heart does not need to work so hard to pump blood, which improves your exercise tolerance.  Now you can exercise without getting so breathless, and you will also find that APO-Diltiazem CD relieves other symptoms of angina like chest pain. 

Relaxation and widening of the arteries taking oxygenated blood to the rest of the body decreases the resistance to blood flow in these peripheral arteries.  Reduced resistance to blood flow has a direct effect on lowering blood pressure, allowing blood pressure to return to within normal levels.  

APO-Diltiazem CD capsules 180mg are formulated for controlled release, which means that the active ingredient is released slowly into the blood.  Therefore, you only need to take your medication once a day.

What does APO-Diltiazem CD contain?

APO-Diltiazem CD capsules 180mg contain the active ingredient diltiazem, a calcium channel blocker that is used to treat chronic stable angina and hypertension.  They also contain methylcellulose, microcrystalline cellulose, tributyl citrate, polysorbate, purified talc, methacrylic acid copolymer, gelatin capsule shell (contains brilliant blue FCF and titanium dioxide as colouring agents).

What are the side effects of APO-Diltiazem CD?

Most medications have some side effects, but they are not experienced by everyone.  Some side effects are commonly experienced when taking APO-Diltiazem CD, but others are not so common, and you should discuss any problems or concerns with your primary care physician. 

Common side effects when taking APO-Diltiazem CD include headache, dizziness, gastrointestinal upset with nausea, vomiting and constipation, oedema (swelling of the ankles, feet, face or hands), arrhythmia (palpitations), fatigue, flushing, rash.

When should APO-Diltiazem CD not be used?

Have a talk with your primary healthcare physician before taking APO-Diltiazem CD so that you have a full understanding of what this medicine is for and how to use it.  There are some reasons for not taking a medication; these are called contraindications, and for APO-Diltiazem CD you should consider the following before taking APO-Diltiazem CD:

• Have you ever had an unusual reaction or an allergy when taking APO-Diltiazem CD?
• Are you allergic to diltiazem, other calcium channel blockers or any ingredients in APO-Diltiazem CD?
• Are you pregnant or breastfeeding?
• Do you have any problems with your kidneys or your liver?
• Do you have certain types of abnormal heart rhythm like sick sinus syndrome?
• Do you have heart problems including, congestive heart failure, left ventricular failure or myocardial infarction with pulmonary congestion?
• Do you have hypotension (low blood pressure)?

What medications interact with APO-Diltiazem CD?

Some medicines interact with APO-Diltiazem CD and may affect the way it works, or are affected by APO-Diltiazem CD or increase side effects; you should discuss possible interactions with your primary care physician.  These may include cimetidine for reflux, digoxin for heart failure, the immunosuppressant cyclosporine, the antiepileptic carbamazepine, nitrates for heart conditions, statins for high cholesterol like simvastatin, theophylline for asthma, benzodiazepines like diazepam for anxiety, lithium for mood disorders, the antiarrhythmic amiodarone, corticosteroids like methylprednisolone..   

If other medications may interact with APO-Diltiazem CD, your doctor will discuss these with you. 

How should APO-Diltiazem CD be taken and for how long?

You should take your APO-Diltiazem CD capsules 180mg swallowed whole with a glass of water, once daily, with or without food.  The dose you take and for how long should be as recommended by your doctor.  If required, your doctor may increase your dose. 

Missed dose of APO-Diltiazem CD

If you miss a dose of APO-Diltiazem CD capsules 180mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should APO-Diltiazem CD be stored?

You should store your APO-Diltiazem CD capsules 180mg below 25°C in a cool dry place.