Scabover (Ivermectin 12mg) Tablets

Scabover general information

What is Scabover used for?

Parasites are organisms that survive by living off another organism called the host.  Some parasites may irritate, but otherwise, do not make their host sick.  However, in many cases, the parasite affects many areas of the host’s body, making the host severely ill.  Scabover tablets 12mg are used to treat parasitic infections caused by parasitic worms and ectoparasites like scabies, to relieve symptoms and prevent the spread of infection. 

Strongyloidiasis is an infection caused by the nematode Strongyloides stercoralis an intestinal parasite belonging to the hookworm group of roundworms.  Infection is by direct contact with contaminated soil.  The larval worms enter the bloodstream, migrate to the lungs, and are then swallowed.  Once in the host intestine, the larvae mature into adults and produce eggs, which hatch, and the next generation of larvae are excreted in the faeces or migrate to other parts of the body.  In this way, the larvae can re-infect the same host.  Strongyloidiasis symptoms include a rash at the site of larval penetration, usually the feet.  Also, gastrointestinal symptoms (diarrhoea, abdominal pain, nausea, and vomiting); other symptoms include low-grade fever, coughing and wheezing, due to the migration of larvae through the lungs.  The infection can be more severe if the parasite spreads throughout the body. 

Lymphatic filariasis, also known as elephantiasis, is caused by the thread-like nematode worm Wuchereria bancrofti.  This parasite is carried by mosquitos and transmitted by a bite from an infected mosquito.  This allows the larvae to enter the bloodstream and migrate to the lymph vessels.  The larvae mature into adults, mate, and produce and microfilariae, which circulate in the blood, ready to infect another mosquito when it bites.  In the mosquito, microfilariae grow into adults, to begin the life cycle again.  Symptoms of lymphatic filariasis include lymphoedema, due to obstruction of the lymphatic system.  This causes swelling in the arms, legs, or genitals, which can be painful and disfiguring. 

Other intestinal nematode parasites include roundworm (ascariasis), whipworm (Trichuriasis), and pinworm (Enterobiasis).

Scabies is a contagious ectoparasitic infection, caused by the parasitic mite Sarcoptes scabiei, transmitted by direct skin contact. The scabies mite burrows into the skin, causing itching as it burrows, which can be intense and is often worse at night.  Within two to six weeks after infection, the mite can cause an allergic reaction.  Symptoms include a rash, seen as small red bumps on the limbs and trunk, which are usually very itchy; also, nodules in the groin or armpit.  Burrow lines can also be seen at the site of infection, generally between the fingers, on the skin of the hands, feet, wrist, elbows, buttocks, and genitals.  If left untreated, scabies infection can cause secondary complications.  These include impetigo (infection and inflammation of superficial skin cells), and cellulitis (inflammation of the lower dermal or subcutaneous skin layers). 

Covid-19

In 2020, when the Covid-19 pandemic began, the search for new agents to treat the virus began with the development of a new vaccine being a core objective. Concurrent with this goal was the search to find an effective treatment amongst existing medications already part of a physicians’ treatment arsenal.

Given the urgency of the situation with regard to developing and testing a vaccine, concerns remain around its effectiveness to treat the infection and save lives, its effectiveness against emerging strains of the virus and its short-term and long-term safety profile.

Initial reports that a treatment protocol using hydroxychloroquine and antibiotics appeared promising, but it now appears that ivermectin is both more effective and has a better safety record.

Treatment of Covid-19 is considered an off-label use for Scabover (Ivermectin) tablets 12mg. Please contact your doctor for advice on treatment with Ivermectin and all Covid-19 related matters.

As a prevention treatment for high risk individuals such as medical staff or those in close contact with Covid-19 patients a dose of ivermectin 0.2mg/kg of body weight is taken on day one, with a second dose in 48 hours followed by a dose every 14 days. 

Please contact us if you need assistance calculating ivermectin dosages for your body weight.

One Scabover (Ivermectin) 12mg tablet is suitable for those that weigh 51-60 Kg (112-132 pounds).

One-and-a-quarter Scabover (Ivermectin) 12mg tablets are suitable for those that weigh 61-75 Kg (134-165 pounds).

One-and-a-half Scabover (Ivermectin) 12mg tablets are suitable for those that weigh 76-90 Kg (167-198 pounds).

One-and-a-three-quarter Scabover (Ivermectin) 12mg tablets are suitable for those that weigh 91-105 Kg (200-231 pounds).

Two Scabover (Ivermectin) 12mg tablets are suitable for those that weigh 106-120 Kg (233-264 pounds).

As a prevention treatment for those exposed to Covid-19 the same treatment is given - a dose of ivermectin 0.2mg/kg of body weight is taken on day one, with a second dose in 48 hours.

An outpatient protocol has been developed for those in the early stages of infection. A single daily dose of 0.2mg/Kg for at least two days but no greater than five days is recommended.

Additionally, Vitamin D3 (4000 iu/day), Vitamin C (1000mg twice daily), Zinc (50-100mg daily) are recommended. We recommend that you seek advice from your doctor and further information from the Front Line Covid-19 Critical Care Alliance website for more details if you are in a high risk situation.

How does Scabover work?

Scabover dispersible tablets 12mg contains ivermectin, an anthelmintic that is used to treat parasitic infections.  Ivermectin in Scabover dispersible tablets 12mg is derived from the avermectins.  These are a series of drugs that are isolated from the fermentation of the soil bacteria Streptomyces avermitilis.  The avermectins are used to treat a variety of parasitic diseases. 

Ivermectin in Scabover tablets 12mg works by interacting directly and specifically with the nervous system of the parasite but does not affect mammals.  Ivermectin in Scabover dispersible tablets 12mg binds strongly to specific receptors in the parasite nerve and muscle cells that are only found in invertebrate cells.  These are the gamma-aminobutyric acid (GABA) and glutamate (GluCl) regulated chloride channels.  Ivermectin binding to these channels causes paralysis and death of the parasite.  Scabover tablets 12mg are effective in interrupting the infectious cycle and helping to prevent the spread of infection. 

What does Scabover contain?

Scabover contains the active ingredient ivermectin (12mg), an anthelmintic used to treat various parasitic diseases.

What are the side effects of Scabover?

Most medications have some side effects, but they are not experienced by everyone.  Some side effects are commonly experienced when taking Scabover tablets 12mg, but others are not so common, and you should discuss any problems or concerns with your primary care physician. 

Common side effects when taking Scabover include transient tachycardia (fast heart rate), flushing, nausea, diarrhoea, nausea, vomiting, abdominal pain, itching skin rash, asthenia (weakness), light-headedness, dizziness, drowsiness, vertigo, tremor

When should Scabover not be used?

Have a talk with your primary healthcare physician before taking Scabover tablets 12mg so that you have a full understanding of what this medicine is for and how to use it.  There are some reasons for not taking a medication; these are called contraindications, and for Scabover, you should consider the following before taking Scabover:

• Have you ever had an unusual reaction or an allergy when taking Scabover?
• Are you pregnant or breastfeeding?
• Do you have any problems with your kidneys or your liver?
• Do you have asthma?
• Do you have another infection with other microfilarial worms such as loa loa?

What medications interact with Scabover?

Some medicines interact with Scabover tablets 12mg and may affect the way it works, or are affected by Scabover or increase side effects; you should discuss possible interactions with your primary care physician.  These may include diethylcarbamazine citrate a rapid action drug for microfilarial infections, and the anticoagulant warfarin. 

If other medications may interact with Scabover tablets 12mg, your doctor will discuss these with you. 

How should Scabover be taken and for how long?

You should take your Scabover tablets 12mg dispersed in a small amount of water (approximately one teaspoon) and then swallowed in one dose.  You can take your Scabover tablet