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Rifakem-550 general information

What is Rifakem-550 used for?

Rifakem 550 is an antibiotic used to treat hepatic encephalopathy (HE) to prevent its recurrence, where other treatments have failed or are contraindicated.  HE is a neuropsychiatric condition in which there is a loss of brain function due to liver damage, such as cirrhosis.  This results in a build-up of toxins like ammonia in the blood, which causes symptoms including confusion, difficulty thinking, loss of fine hand movements, behaviour changes and a musty or sweet smelling breath.  It is thought that an imbalance of the intestinal microbiota (good versus bad bacteria) with a higher proportion of pathogenic bacteria, may contribute to the pathogenesis of several diseases including liver cirrhosis.  Rifakem-550 is effective against a wide range of intestinal bacteria, including those like Streptococcus salivarius that produce ammonia.  Ammonia is a toxin that a healthy liver would convert into urea which is then excreted in the urine, but in a damaged liver this process is impaired.  Rifakem tablets 550mg help restore the balance in the composition of intestinal bacteria and reduce risk of HE and its recurrence¹.  Rifakem-550 cannot be used to treat other infections as it is not absorbed into the blood and therefore, only acts locally in the gastrointestinal tract to kill local bacteria.   

How does Rifakem-550 work?

Rifakem tablets 550mg contain rifaximin, a locally acting antibiotic belonging to the rifamycin class of antibiotics.  It is a non-systemic antibiotic, which means it acts locally in the intestines and is not absorbed into the circulation.  Rifaximin in Rifakem 550 works by binding to the bacterial enzyme DNA-dependent RNA polymerase and this action inhibits bacterial RNA synthesis.  This prevents RNA transcription and thereby the production of bacterial proteins, which inhibits growth of the bacteria.  Rifaximin in Rifakem 550 is effective against bacteria that break down proteins in the intestines by the process of deamination resulting in ammonia production, reducing the high blood levels of ammonia that contribute to the pathogenesis of hepatic encephalopathy^2-5.

What does Rifakem-550 contain?

Rifakem tablets contain the active ingredient rifaximin 550mg, a locally acting antibiotic used to prevent the recurrence of hepatic encephalopathy where other treatments have failed or are contraindicated.  

Rifakem-550 for hepatic encephalopathy

Rifakem tablets 550mg contain rifaximin, a locally acting antibiotic that is used to treat hepatic encephalopathy to prevent its recurrence where other treatments have failed or are contraindicated.  Hepatic encephalopathy is a neuropsychiatric condition in which there is a loss of brain function due to liver damage, such as cirrhosis.  This results in a build-up of toxins in the blood, such as ammonia which causes symptoms including confusion, difficulty thinking, loss of fine hand movements, behaviour changes and a musty or sweet smelling breath.  Rifaximin in Rifakem 550 is effective against bacteria that break down proteins in the intestines by deamination resulting in ammonia production.  A healthy liver would normally convert ammonia into urea which is then excreted in the urine, but in a damaged liver this process is impaired.  Rifaximin in Rifakem-550 inhibits growth of ammonia producing bacteria, reducing the high blood levels of ammonia that contribute to the pathogenesis of hepatic encephalopathy.

What are the side effects of Rifakem-550?

The most commonly reported side effects when taking Rifakem-550 include dizziness, headache, fever, fatigue, abdominal pain, constipation, defecation urgency, diarrhoea, flatulence, bloating and distension, nausea and vomiting, oedema, rash.  Rifakem-550 can result in Clostridium difficile-associated diarrhoea (CDAD), which is a more serious form of diarrhoea ranging in severity from mild to life-threatening and is due to the changes in intestinal flora that happens when taking antibiotics. 

When should Rifakem-550 not be used?

You should not use Rifakem-550 if you:

• are allergic to rifaximin or any ingredients in Rifakem-550
• are pregnant or are breastfeeding
• have severe liver disease, without discussion with your doctor
• have any form of intestinal obstruction
• are taking medicines that interact with Rifakem-550, including other rifamycin antibiotics and the immunosuppressant ciclosporin.  Rifakem-550 reduces the effect of warfarin

How should Rifakem-550 be taken?

For hepatic encephalopathy you should take your Rifakem-550 swallowed whole with a glass of water with or without food twice daily for 6 months.  The dose you take should be as recommended by your doctor.  You should only continue to take your Rifakem-550 beyond 6 months based on your doctor’s recommendation, after evaluation by your doctor of how well you are responding and any side effects you are experiencing.  

How long should you take Rifakem-550?

You should only continue to take your Rifakem-550 beyond 6 months based on your doctor’s recommendation, after evaluation by your doctor of how well you re responding and any side effects you are experiencing. 

Missed dose of Rifakem-550

If you miss a dose of Rifakem-550 take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Rifakem-550 be stored?

You should store your Rifakem-550 below 25°C in a cool dry place. 

References

1. Ponziani FR, Gerardi V, Pecere S, D'Aversa F, Lopetuso L, Zocco MA, Pompili M, Gasbarrini A. Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications. World J Gastroenterol. 2015 Nov 21;21(43):12322-33.
2. Zeng X, Tang XJ, Sheng X, Ni W, Xin HG, et al. Does low-dose rifaximin ameliorate endotoxemia in patients with liver cirrhosis: a prospective study. J Dig Dis 2015 Nov;16(11):665-74.
3. Shayto RH, Abou Mrad R, Sharara AI. Use of rifaximin in gastrointestinal and liver diseases. World J Gastroenterol. 2016 Aug 7;22(29):6638-51.
4. Peleman C, Camilleri M. Rifaximin, Microbiota Biology, and Hepatic Encephalopathy. Clin Transl Gastroenterol 2016 Oct 6;7(10):
5. Iadevaia MD, Del Prete A, Cesaro C, Gaeta L, Zulli C, Loguercio C.  Rifaximin in the treatment of hepatic encephalopathy. Hepat Med 2011; 3: 109–117.

Newven general information

What is Newven used for?

Newven tablets 100mg are used to treat major depression and symptoms of depressive illness, including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.  Newven tablets 100mg are also used to treat other mood disorders that affect daily activities and relationships with others including, social anxiety disorder (Social Phobia), panic disorder (panic attacks) and generalised anxiety disorder.   Newven tablets 100mg help manage the emotional and physical symptoms of depression to help improve ability to function at work, in family and social life and in leisure activities.

How does Newven work?

Newven tablets 100mg contain desvenlafaxine which is the active metabolite of venlafaxine, an antidepressant belonging to the class of drugs known as Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs) but is structurally and chemically different to other antidepressants.  Desvenlafaxine in Newven tablets 100mg acts in the brain to correct the chemical imbalance caused by a lack of certain neurotransmitters (brain chemical that allows nerve cells to communicate) that is thought to be one of the major causes of depression and other mood disorders, particularly a lack of serotonin, which controls many body activities, including regulating mood.  Desvenlafaxine is a potent inhibitor of the reuptake of serotonin and noradrenaline, and also weakly inhibits dopamine reuptake, which means that it blocks the re-uptake of serotonin and noradrenaline from the synapse (the gap between nerve cells across which chemical messages are sent from one nerve cell to another).  If the re-uptake of serotonin and noradrenaline by the first nerve cell (pre-synaptic) is blocked, this means that there is more neurotransmitter remaining for the receiving nerve cell (post-synaptic), which allows nerve cells to communicate with each other for longer.  The action of Newven tablets 100mg helps relieve symptoms of depression and other mood disorders by increasing the amount of serotonin and noradrenaline in the brain, which in turn increases stimulation of nerve pathways that control mood.  Newven tablets 100mg are formulated so that desvenlafaxine is released slowly into the digestive system for extended-release of the medication, to allow for a single dose per day.

What does Newven contain?

Newven tablets 100mg contain the active ingredient desvenlafaxine, an antidepressant belonging to the Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs) that are used to treat depression and other mood disorders. 

Treating depression with Newven

Newven tablets 100mg contain desvenlafaxine which is the active metabolite of venlafaxine, an antidepressant belonging to the class of drugs known as Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs).  Newven tablets 100mg are used to treat symptoms of depression, including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating and recurrent thoughts of suicide.  One of the major causes of depression is thought to be an imbalance of neurotransmitters (brain chemicals that allows nerve cells to communicate), particularly a lack of serotonin that controls mood.  Desvenlafaxine in Newven tablets 100mg works by specifically blocking the reuptake of serotonin and noradrenaline from the synapse, or gap between nerve cells across which chemical messages are sent to allow nerve cell to communicate with each other.  By preventing the reuptake of serotonin and noradrenaline by the first nerve cell (pre-synaptic) there is more neurotransmitter remaining for the receiving nerve cell (post-synaptic), so that nerve cells can communicate with each other for longer which increases stimulation of nerve pathways that control mood changes, relieving symptoms of depression. 

What are the side effects of Newven?

The most commonly reported side effects when taking Newven tablets 100mg include: decreased or loss of appetite, dry mouth, diarrhoea, nausea, constipation, sleeplessness, fatigue, drowsiness, increased sweating, vasodilation (hot flashes), hypertension (increase in blood pressure), sexual problems.

When should Newven not be used?

You should not use Newven tablets 100mg if you:

• are allergic to desvenlafaxine or any ingredients in Newven
• are pregnant or are breastfeeding
• have liver disease
• have a recent history of myocardial infarction or unstable heart disease
• are taking any monoamine oxidase inhibitor medications (such as phenelzine and tranylcypromine) as these can cause serious reactions if taken with Newven or within 14 days
• are taking medicines that interact with Newven monoamine oxidase inhibitors (MAOIs) for depression, other antidepressants, the analgesic tramadol, tryptophan, or phentermine (weight-reducing medicines), sumatriptan for migraine, the antipsychotic pimozide, herbal remedies containing St. John´s Wort, bupropion, for nicotine dependence, the antifungal ketoconazole, the antibiotic erythromycin, clozapine for schizophrenia
• are taking medication that affects blood clotting as these may increase risk of bleeding if taken with Newven

What medications interact with Newven?

Several medications interact with Newven tablets 100mg and should either not be taken while you are taking Newven or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with Newven: monoamine oxidase inhibitors (MAOIs) like phenelzine and tranylcypromine for depression, medication that affects blood clotting like warfarin
• Drugs that affect Newven: the analgesic tramadol, tryptophan, or phentermine (weight-reducing medicines), sumatriptan for migraine, St John's wort, a herbal remedy used to treat mood disorders, cimetidine for reflux and ulcers, antifungal ketoconazole, the antibiotic erythromycin
• Drugs that are affected by Newven: the antidepressants lithium and Imipramine, clozapine for schizophrenia, the anticoagulant warfarin

How should Newven be taken?

You should take your Newven tablets 100mg with a glass of water, swallowed whole with or without food You should take your Newven tablets 100mg swallowed whole with a glass of water, with or without food once a day, at the same time each day.  Your doctor may increase your dose, depending on what you are being treated for.  You should continue take your Newven tablets 100mg for as long as recommended by your doctor, depending on your condition and your doctor’s recommendations, usually for several weeks or months and you should continue your medication even if you feel well. 

How long should you take Newven?

You should continue take your Newven tablets 100mg for as long as recommended by your doctor, depending on your condition and your doctor’s recommendations, usually for several weeks or months and you should continue your medication even if you feel well.

Missed dose of Newven

If you miss a dose of Newven tablets 100mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Newven be stored?

You should store your Newven tablets 100mg below 25°C in a cool dry place. 

Cipflox general information

What is Cipflox used for?

Cipflox tablets 500mg are an antibiotic medication used to treat uncomplicated and complicated bacterial infections in adults, caused by a wide range of susceptible bacteria in various parts of the body.  Cipflox tablets 500mg are used to treat pneumonia (community acquired as outpatients), caused by various bacteria, but should not be the antibiotic of first choice for pneumonia caused by Pneumococcus.  Cipflox tablets 500mg are also use to treat infections of the skin and soft tissue, such as impetigo and cellulitis; also of the bones and joints, which can be very painful; and infections of the abdominal cavity such as peritonitis.  Cipflox tablets 500mg are also used to treat infections of the urogenital system, including adnexitis (infection and inflammation of the ovary and the fallopian tubes), prostatitis (infection and inflammation of the prostate), gonorrhoea, infections of the efferent urinary tract like cystitis and pyelonephritis (infection and inflammation of the kidney).  Cipflox tablets 500mg are used to treat sepsis, which is a serious and life-threatening condition that occurs as a result of the body’s response to an infection.  It is caused by chemicals released into the bloodstream to fight the infection, which can result in damage to tissues and organs.  Cipflox tablets 500mg may also be used after inhalation of anthrax spores, as post exposure prophylaxis to reduce risk of pulmonary disease.  Cipflox tablets 500mg are also used to treat acute pulmonary exacerbation of cystic fibrosis caused by the bacteria Pseudomonas aeruginosa; also complicated urinary tract infections or pyelonephritis due to E.coli in children over the age of 5 years.   

How does Cipflox work?

Cipflox tablets 500mg contain the antibiotic ciprofloxacin that belongs to the fluoroquinolones group of antibiotics and is a synthetic broad spectrum antibiotic with antibacterial activity against a wide range of bacteria including, Klebsiella, Haemophilus, Enterobacter, E. coli, Pseudomonas, Legionella, Staphylococcus, Streptococcus, Listeria and Chlamydia.  Ciprofloxacin in Cipflox tablets 500mg works by inhibiting several bacterial enzymes (bacterial topoisomerase IV and DNA gyrase) needed for the bacteria to replicate and repair its DNA.  This action of ciprofloxacin in Cipflox tablets 500mg kills the bacteria by blocking its growth and preventing the spread of infection.  Cipflox tablets 500mg do not work against viruses which use a different mechanism to grow and replicate.  

What does Cipflox contain?

Cipflox tablets 500mg contain the active ingredient ciprofloxacin, a synthetic broad spectrum antibiotic used to treat a wide range of bacterial infections.  They also contain microcrystalline cellulose, maize starch, pregelatinised maize starch, crospovidone, colloidal anhydrous silica, magnesium stearate, titanium dioxide, polydextrose, hypromellose, glycerol triacetate, macrogol.

Treating bacterial infection with Cipflox

Cipflox tablets 500mg contain ciprofloxacin a synthetic broad spectrum fluoroquinolone antibiotic that used to treat uncomplicated and complicated bacterial infections in adults, caused by a wide range of susceptible bacteria in various parts of the body.  Infections that Cipflox tablets 500mg are suitable for include, pneumonia; infections of the skin, soft tissue bones and joints; infections of the urogenital system; infections of the abdominal cavity; sepsis and to reduce risk of pulmonary disease following inhalation of anthrax spores.  Cipflox tablets 500mg are also used to treat acute pulmonary exacerbation of cystic fibrosis and complicated urinary tract infections in children over the age of 5 years.  Ciprofloxacin in Cipflox tablets 500mg works by inhibiting several bacterial enzymes needed for the bacteria to replicate and repair its DNA.  This action of ciprofloxacin in Cipflox tablets 500mg kills the bacteria by blocking its growth and preventing the spread of infection. 

What are the side effects of Cipflox?

The most commonly reported side effects when taking Cipflox tablets 500mg include diarrhoea, nausea, vomiting, abdominal pain, rash, headache, altered taste, arthralgia (joint pain).  Very rarely taking Cipflox tablets 500mg is associated with an increased risk of tendonitis and tendon rupture with increased risk if you are over the age of 60 years, taking systemic steroids or have received a kidney, heart or lung transplant.

When should Cipflox not be used?

You should not use Cipflox tablets 500mg if you:

• are allergic to ciprofloxacin or any ingredients in Cipflox
• are pregnant or are breastfeeding
• have kidney or liver disease
• history of tendon disease/disorder related to quinolone treatment
• have epilepsy or a history of convulsion
• have a history of stroke, heart attack or heart failure, without discussion with your doctor
• have myasthenia gravis
• are taking medicines that interact with Cipflox, including the muscle relaxant tizanidine for cystic fibrosis, anti-arrhythmics like amiodarone, tricyclic antidepressants like amitriptylene, macrolides antibiotics like azithromycin, clarithromycin, antipsychotics like olanzapine,, mineral supplements, sucralfate, omeprazole or antacids for ulcers and reflux, probenecid for gout, theophylline for asthma, caffeine and methylxanthines (found in some medicines and in drinks such as coffee, tea, cola), phenytoin for seizures, some NSAIDs (non-steroidal anti-inflammatory drugs), the immunosuppressant cyclosporine, anticoagulants like warfarin, oral antidiabetic medications like glibenclamide, methotrexate for cancer treatment, the antiemetic metoclopramide, the antidepressant duloxetine, ropinirole for Parkinson’s disease, clozapine for schizophrenia, sildenafil for erectile dysfunction

What medications interact with Cipflox?

Several medications interact with Cipflox tablets 500mg and should either not be taken while you are taking Cipflox or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction or increase side effects with Cipflox: the muscle relaxant tizanidine for cystic fibrosis, anti-arrhythmics like amiodarone, tricyclic antidepressants like amitriptylene, macrolides antibiotics like azithromycin, clarithromycin, antipsychotics like olanzapine, theophylline for asthma, some NSAIDs (non-steroidal anti-inflammatory drugs), the immunosuppressant cyclosporine,
• Drugs that affect Cipflox: mineral supplements, sucralfate, omeprazole or antacids for ulcers and reflux, probenecid for gout, the antiemetic metoclopramide
• Drugs that are affected by Cipflox: the muscle relaxant tizanidine for cystic fibrosis, theophylline for asthma, caffeine and methylxanthines (found in some medicines and in drinks such as coffee, tea, cola), phenytoin for seizures, anticoagulants like warfarin, oral antidiabetic medications like glibenclamide, methotrexate for cancer treatment, the antidepressant duloxetine, ropinirole for Parkinson’s disease, clozapine for schizophrenia, sildenafil for erectile dysfunction

How should Cipflox be taken?

You should take your Cipflox tablets 500mg swallowed whole with a glass of water, with or without food.  The dose you take and how often, depends on what you are being treated for and your doctor’s recommendations, which for most infections is usually one tablet twice daily for 7 to 14 days, but the dose or length of time you need to take your Cipflox tablets 500mg for may be increased depending on the severity of your infection and your response to treatment.  You should not consume dairy products that are high in calcium (milk and yoghurt) or calcium-fortified orange juice, unless they are part of a meal as this may affect the absorption of ciprofloxacin.  Avoid direct exposure to excessive sunlight or UV-light as this can cause photosensitisation (sunburn-like skin reactions).  You should continue to take your Cipflox tablets 500mg for as long as recommended by your doctor.

How long should you take Cipflox?

You should continue to take your Cipflox tablets 500mg for as long as recommended by your doctor.

Missed dose of Cipflox

If you miss a dose of Cipflox tablets 500mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Cipflox be stored?

You should store your Cipflox tablets 500mg below 25°C in a cool dry place.  

Cipflox general information

What is Cipflox used for?

Cipflox tablets 250mg are an antibiotic medication used to treat uncomplicated and complicated bacterial infections in adults, caused by a wide range of susceptible bacteria in various parts of the body.  Cipflox tablets 250mg are used to treat pneumonia (community acquired as outpatients), caused by various bacteria, but should not be the antibiotic of first choice for pneumonia caused by Pneumococcus.  Cipflox tablets 250mg are also use to treat infections of the skin and soft tissue, such as impetigo and cellulitis; also of the bones and joints, which can be very painful; and infections of the abdominal cavity such as peritonitis.  Cipflox tablets 250mg are also used to treat infections of the urogenital system, including adnexitis (infection and inflammation of the ovary and the fallopian tubes), prostatitis (infection and inflammation of the prostate), gonorrhoea, infections of the efferent urinary tract like cystitis and pyelonephritis (infection and inflammation of the kidney).  Cipflox tablets 250mg are used to treat sepsis, which is a serious and life-threatening condition that occurs as a result of the body’s response to an infection.  It is caused by chemicals released into the bloodstream to fight the infection, which can result in damage to tissues and organs.  Cipflox tablets 250mg may also be used after inhalation of anthrax spores, as post exposure prophylaxis to reduce risk of pulmonary disease.  Cipflox tablets 250mg are also used to treat acute pulmonary exacerbation of cystic fibrosis caused by the bacteria Pseudomonas aeruginosa; also complicated urinary tract infections or pyelonephritis due to E.coli in children over the age of 5 years.   

How does Cipflox work?

Cipflox tablets 250mg contain the antibiotic ciprofloxacin that belongs to the fluoroquinolones group of antibiotics and is a synthetic broad spectrum antibiotic with antibacterial activity against a wide range of bacteria including, Klebsiella, Haemophilus, Enterobacter, E. coli, Pseudomonas, Legionella, Staphylococcus, Streptococcus, Listeria and Chlamydia.  Ciprofloxacin in Cipflox tablets 250mg works by inhibiting several bacterial enzymes (bacterial topoisomerase IV and DNA gyrase) needed for the bacteria to replicate and repair its DNA.  This action of ciprofloxacin in Cipflox tablets 250mg kills the bacteria by blocking its growth and preventing the spread of infection.  Cipflox tablets 250mg do not work against viruses which use a different mechanism to grow and replicate.  

What does Cipflox contain?

Cipflox tablets 250mg contain the active ingredient ciprofloxacin, a synthetic broad spectrum antibiotic used to treat a wide range of bacterial infections.  They also contain microcrystalline cellulose, maize starch, pregelatinised maize starch, crospovidone, colloidal anhydrous silica, magnesium stearate, titanium dioxide, polydextrose, hypromellose, glycerol triacetate, macrogol.

Treating bacterial infection with Cipflox

Cipflox tablets 250mg contain ciprofloxacin a synthetic broad spectrum fluoroquinolone antibiotic that used to treat uncomplicated and complicated bacterial infections in adults, caused by a wide range of susceptible bacteria in various parts of the body.  Infections that Cipflox tablets 250mg are suitable for include, pneumonia; infections of the skin, soft tissue bones and joints; infections of the urogenital system; infections of the abdominal cavity; sepsis and to reduce risk of pulmonary disease following inhalation of anthrax spores.  Cipflox tablets 250mg are also used to treat acute pulmonary exacerbation of cystic fibrosis and complicated urinary tract infections in children over the age of 5 years.  Ciprofloxacin in Cipflox tablets 250mg works by inhibiting several bacterial enzymes needed for the bacteria to replicate and repair its DNA.  This action of ciprofloxacin in Cipflox tablets 250mg kills the bacteria by blocking its growth and preventing the spread of infection. 

What are the side effects of Cipflox?

The most commonly reported side effects when taking Cipflox tablets 250mg include diarrhoea, nausea, vomiting, abdominal pain, rash, headache, altered taste, arthralgia (joint pain).  Very rarely taking Cipflox tablets 250mg is associated with an increased risk of tendonitis and tendon rupture with increased risk if you are over the age of 60 years, taking systemic steroids or have received a kidney, heart or lung transplant.

When should Cipflox not be used?

You should not use Cipflox tablets 250mg if you:

• are allergic to ciprofloxacin or any ingredients in Cipflox
• are pregnant or are breastfeeding
• have kidney or liver disease
• history of tendon disease/disorder related to quinolone treatment
• have epilepsy or a history of convulsion
• have a history of stroke, heart attack or heart failure, without discussion with your doctor
• have myasthenia gravis
• are taking medicines that interact with Cipflox, including the muscle relaxant tizanidine for cystic fibrosis, anti-arrhythmics like amiodarone, tricyclic antidepressants like amitriptylene, macrolides antibiotics like azithromycin, clarithromycin, antipsychotics like olanzapine,, mineral supplements, sucralfate, omeprazole or antacids for ulcers and reflux, probenecid for gout, theophylline for asthma, caffeine and methylxanthines (found in some medicines and in drinks such as coffee, tea, cola), phenytoin for seizures, some NSAIDs (non-steroidal anti-inflammatory drugs), the immunosuppressant cyclosporine, anticoagulants like warfarin, oral antidiabetic medications like glibenclamide, methotrexate for cancer treatment, the antiemetic metoclopramide, the antidepressant duloxetine, ropinirole for Parkinson’s disease, clozapine for schizophrenia, sildenafil for erectile dysfunction

What medications interact with Cipflox?

Several medications interact with Cipflox tablets 250mg and should either not be taken while you are taking Cipflox or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction or increase side effects with Cipflox: the muscle relaxant tizanidine for cystic fibrosis, anti-arrhythmics like amiodarone, tricyclic antidepressants like amitriptylene, macrolides antibiotics like azithromycin, clarithromycin, antipsychotics like olanzapine, theophylline for asthma, some NSAIDs (non-steroidal anti-inflammatory drugs), the immunosuppressant cyclosporine,
• Drugs that affect Cipflox: mineral supplements, sucralfate, omeprazole or antacids for ulcers and reflux, probenecid for gout, the antiemetic metoclopramide
• Drugs that are affected by Cipflox: the muscle relaxant tizanidine for cystic fibrosis, theophylline for asthma, caffeine and methylxanthines (found in some medicines and in drinks such as coffee, tea, cola), phenytoin for seizures, anticoagulants like warfarin, oral antidiabetic medications like glibenclamide, methotrexate for cancer treatment, the antidepressant duloxetine, ropinirole for Parkinson’s disease, clozapine for schizophrenia, sildenafil for erectile dysfunction
  

How should Cipflox be taken?

You should take your Cipflox tablets 250mg swallowed whole with a glass of water, with or without food.  The dose you take and how often, depends on what you are being treated for and your doctor’s recommendations, which for most infections is usually one tablet twice daily for 7 to 14 days, but the dose or length of time you need to take your Cipflox tablets 250mg for may be increased depending on the severity of your infection and your response to treatment.  You should not consume dairy products that are high in calcium (milk and yoghurt) or calcium-fortified orange juice, unless they are part of a meal as this may affect the absorption of ciprofloxacin.  Avoid direct exposure to excessive sunlight or UV-light as this can cause photosensitisation (sunburn-like skin reactions).  You should continue to take your Cipflox tablets 250mg for as long as recommended by your doctor.

How long should you take Cipflox?

You should continue to take your Cipflox tablets 250mg for as long as recommended by your doctor.

Missed dose of Cipflox

If you miss a dose of Cipflox tablets 250mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Cipflox be stored?

You should store your Cipflox tablets 250mg below 25°C in a cool dry place.  

Myloc CR general information

What is Myloc CR used for?

Myloc CR tablets 23.75mg are used to treat a variety of conditions of the cardiovascular system including, control of hypertension (high blood pressure) by lowering blood pressure to reduce the risk of complications such as stroke and heart attack; management of angina (chest pain) in patients with heart disease; long-term prevention of myocardial infarction (heart attack); treatment of heart failure to improve survival and quality of life; and control of most forms of arrhythmias and dysrhythmias (irregular heart beat or rhythm) and palpitations. Myloc CR tablets are also used for preventing migraine, and as a supplementary treatment for hyperthyroidism (overactive thyroid). Myloc CR tablets work through a common mechanism in several different body systems to manage the condition and relieve symptoms by reducing heart rate (pulse), workload on the heart (force needed to pump) and oxygen demand by the heart, which increases blood flow and lowers blood pressure.

How does Myloc CR work?

Myloc CR tablets 23.75mg contain metoprolol, which is a beta-blocker or selective beta 1-receptor antagonist and acts by blocking the action of chemicals called catecholamines, such as adrenaline (epinephrine), which are released by the adrenal glands in response to nerve stimulation during physical and mental stress. Adrenaline works via beta-receptors in the heart to stimulate increased heart rate and constriction (narrowing) of blood vessels. These actions of adrenaline are reduced or inhibited by metoprolol in Myloc CR tablets, to slow heart rate, dilate (widen) blood vessels, lower blood pressure, and increase blood flow and oxygen to the heart. Since beta-receptors are found in many tissues, particularly the heart, kidneys, vascular smooth muscle in blood vessel walls, lung, skeletal muscle and liver, all short-term and long-term symptom relief due to taking Myloc CR, is based on blocking beta-receptors in the target tissue. Myloc CR tablets are formulated for controlled release so that metoprolol is that released in a sustained and time controlled manner, to ensure a more even effect over 24 hours, which provides better symptom relief with fewer side effects.

What does Myloc CR contain?

Myloc CR tablets 23.75mg contain the active ingredient metoprolol succinate, a beta-blocker used to treat variety of conditions of the cardiovascular system and other conditions. They also contain ethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, microcrystalline cellulose, paraffin, polyethylene glycol, silicon dioxide, sodium stearyl fumarate, titanium dioxide

What Myloc CR doses are available?

Myloc CR tablets are available to order and buy online from Inhouse Pharmacy in doses of 23.75mg, 47.5mg, 95mg and 190mg.

Treating blood pressure (hypertension) with Myloc CR

Myloc CR tablets 23.75mg contain metoprolol, which is a beta-blocker and acts by blocking the action of chemicals called catecholamines, such as adrenaline (epinephrine), which are released by the adrenal glands in response to nerve stimulation during physical and mental stress. Myloc CR tablets 23.75mg are used to treat high blood pressure (hypertension) by widening blood vessels, reducing heart rate (number of heart beats) and reducing the force of the heart contraction. These actions lower blood pressure and help the heart to cope better, reducing symptoms of breathlessness on exertion and reducing the risk of complications such as stroke and heart attack, due to high blood pressure.

Treating heart disease with Myloc CR

Myloc CR tablets 23.75mg contain metoprolol, which is a beta-blocker and acts by blocking the action of chemicals called catecholamines, such as adrenaline (epinephrine), which are released by the adrenal glands in response to nerve stimulation during physical and mental stress. Myloc CR tablets 23.75mg are used to treat a variety of conditions of the cardiovascular system to improve survival, reduce symptoms and improve the quality of life in patients with heart disease, including, control of hypertension (high blood pressure), management of angina (chest pain); long-term prevention of myocardial infarction (heart attack) and treatment of heart failure.

What are the side effects of Myloc CR?

The mot common side effects reported while taking Myloc CR tablets 23.75mg include: tiredness, dizziness when you change position, cold hands and feet, nausea, vomiting, diarrhoea, stomach pain, constipation, palpitations, weight gain, sleep disturbances or nightmares, shortness of breath on exertion, mood changes or confusion, dry eyes.

When should Myloc CR not be used?

You should not use Myloc CR tablets 23.75mg if you:

• are allergic to metoprolol or any other ingredients in Myloc CR tablets
• have a history of obstructive lung disorder, bronchial asthma or bronchospasm
• are diabetic and taking hypoglycaemic therapy, without discussion with your doctor as metoprolol may prolong the hypoglycaemic response to insulin
• are pregnant or breast feeding, without discussion with your doctor
• have, poor peripheral blood circulation, uncontrolled heart failure, low blood pressure (hypotension),
• have a phaeochromocytoma (a rare tumour of the adrenal gland) which is not already being treated with other medicines
• have certain other heart problems
• are taking medication that may interact with Myloc CR tablets, including: other medicines for high blood pressure; angina or an irregular heart beat such as calcium channel blockers (diltiazem, verapamil, and nifedipine), antiarrhythmics (disopyramide) digoxin, clonidine, hydralazine; other beta-blockers, including eye drops; the antibiotic rifampicin; adrenaline for emergencies like anaphylaxis; monoamine oxidase inhibitors; antiinflammatories like ibuprofen or indomethacin; cimetidine for reflux and ulcers; chlorpromazine for psychiatric disorders.

How should Myloc CR be taken?

You should take your Myloc CR tablets 23.75mg with a glass of water, swallowed whole, with or without food, usually once daily either morning or evening, but at the same time each day. You should take Myloc CR tablets according to your doctor’s recommendations and the number of capsules you take each day, how often you take them and for how long depends on the condition you are being treated for. The dose you are taking may be increased by your doctor. You must take your capsules every day, as instructed and if you are advised to stop taking them, withdrawal should be gradual and treatment should not be discontinued abruptly.

How long should you take Myloc CR?

You should take your Myloc CR tablets 23.75mg for as long as your doctor recommendations, which may be for a few days, weeks, months or longer depending on the condition you are being treated for.

Missed dose of Myloc CR

If you miss a dose of Myloc CR tablets 23.75mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Myloc CR be stored?

You should store your Myloc CR tablets 23.75mg in a cool dry place below 25°C, protected from light and moisture.