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Isentress 400mg (Raltegravir)

Isentress general information

What is Isentress used for?

Isentress tablets 400mg are used to treat Human Immunodeficiency Virus (HIV) infection, in combination with other HIV medications.  This combination therapy is known as highly active antiretroviral therapy (HAART).  HIV impairs the immune system by attacking specific immune cells called CD4+ cells that are involved in fighting infection, which can lead to opportunistic life-threatening infection (infections that would not normally be harmful).  If too many CD4+ cells are destroyed this can result in acquired immune deficiency syndrome (AIDS).  Isentress tablets 400mg help prevent or slow down the ability of HIV to replicate, which reduces the viral load by keeping the amount virus down to a low level and this results in an increase in CD4 cell numbers, so that the immune system can recover reducing the risk of disease progression. 

How does Isentress work?

Isentress tablets 400mg contains the antiretroviral raltegravir, an integrase strand transfer inhibitor.  Raltegravir in Isentress tablets 400mg inhibits the catalytic activity of HIV integrase, an HIV-encoded enzyme that is required for viral replication.  HIV is a retrovirus, which is an RNA virus that produces an enzyme called reverse transcriptase to transcribe its RNA into DNA.  Another viral enzyme, integrase, is used to insert or integrate viral DNA into the host cell genome during the early phase of infection.  By blocking the action of viral integrase, raltegravir in Isentress tablets 400mg prevents replication of the virus and thereby inhibits production of new infectious viral particles.  Isentress tablets 400mg slow down the replication of HIV within your body but does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others. 

What does Isentress contain?

Isentress tablets 400mg contain the active ingredient raltegravir, an antiretroviral used in the treatment of Human Immunodeficiency Virus (HIV) infection.  They also contain microcrystalline cellulose, lactose monohydrate, calcium phosphate dibasic anhydrous, hypromellose 2208, poloxamer 407, sodium stearyl fumarate, magnesium stearate.

Treating HIV infection with Isentress

Isentress tablets 400mg contain the antiretroviral drug raltegravir, an inhibitor of the viral integrase enzyme.  HIV impairs the immune system by attacking specific immune cells called CD4+ cells that are involved in fighting infection, and this can lead to opportunistic life-threatening infection (infections that would not normally be harmful), including pneumonia, herpes virus infections, and Mycobacterium avium complex (MAC) infection.  If too many CD4+ cells are destroyed this can result in acquired immune deficiency syndrome (AIDS).  HIV is a retrovirus, which is an RNA virus that produces an enzyme called reverse transcriptase to transcribe its RNA into DNA.  Another viral enzyme, integrase, is used to insert or integrate viral DNA into the host cell genome during the early phase of infection.  Raltegravir in Isentress tablets 400mg works by blocking the action of the viral integrase and this inhibits viral replication and thereby inhibits production of new infectious viral particles.  Isentress tablets 400mg are used in combination with other HIV medications to slow down the replication of HIV within your body but they do not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others. 

What are the side effects of Isentress?

The most commonly reported side effects when taking Isentress tablets 400mg include: nausea, vomiting, headaches, tiredness, inflammation of the nasal passages and throat, trouble sleeping, upper respiratory tract infection, cough, fever, bronchitis, back pain and depression.  A more serious but less common side effect is a condition is a severe skin reaction including Stevens-Johnson syndrome and toxic epidermal necrolysis.

When should Isentress not be used?

You should not use Isentress tablets 400mg if you:

  • are allergic to raltegravir or any ingredients in Isentress
  • are pregnant or are breastfeeding
  • are taking medicines that interact with Isentress, including antacids containing aluminium and/or magnesium, the anti-infective rifampicin

How should Isentress be taken?

You should take your Isentress tablets 400mg with a glass of water twice daily, with or without food and in combination with other antiretroviral drugs that have been prescribed.  You should continue to take your Isentress tablets 400mg for as long as recommended by your doctor, and you will be monitored carefully to ensure that you do not develop any serious side effects, in which case your doctor will probably recommend that you stop taking your Isentress tablets 400mg. 

How long should you take Isentress?

You should continue to take your Isentress tablets 400mg for as long as recommended by your doctor, and you will be monitored carefully to ensure that you do not develop any serious side effects, in which case your doctor will probably recommend that you stop taking your Isentress tablets 400mg. 

Missed dose of Isentress

If you miss a dose of Isentress tablets 400mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Isentress be stored?

You should store your Isentress below 25°C in a cool dry place. 

Spiractin 25 (Spironolactone)

Spiractin general information

What is Spiractin used for?

Spiractin tablets 25mg are used to reduce fluid retention and swelling (oedema) which is caused by several conditions, including congestive heart failure, hypertension (high blood pressure), liver cirrhosis and kidney disease.  Spiractin 25 can be used alone to treat hypertension or in combination with other antihypertensive medications like beta blockers, to enhance their activity.  Spiractin tablets 25mg is also used to increase blood potassium levels, which occurs in a condition called hypokalaemia (low blood potassium) and to treat hyperaldosteronism, which is caused by excess secretion by the adrenal gland of the hormone aldosterone (involved in regulating sodium and potassium levels), both of which can cause fluid retention.  Spiractin 25 has anti-androgen activity which is used in the treatment of female hirsutism (androgen-related increase in facial and body hair) and can be used as an anti-androgen component of transgender hormone therapy, to help stimulate the development of female sexual characteristics for male to female transsexuals.    

How does Spiractin work?

Spiractin tablets 25mg contain spironolactone, a potassium-sparing diuretic (water pill) that acts as an antagonist of the hormone aldosterone, by binding to the aldosterone receptor blocking its action.  This action of spironolactone in Spiractin tablets 25mg increases sodium excretion and reduces potassium loss at the distal renal tubule of the kidney.  The overall effect of this action is to increase water excretion in the urine which reduces fluid build-up in the tissues, increase blood potassium levels and lower sblood pressure.  Spironolactone in Spiractin tablets 25mg also has moderate anti-androgenic activity as it binds to the androgen receptor competing with dihydrotestosterone (DHT) an active metabolite of testosterone.  Binding of DHT to the androgen receptor promotes male characteristics therefore, blocking the action of DHT helps reduce male characteristics.  Another anti-androgenic action of Spiractin 25 is that it blocks the synthesis of a testosterone by the ovaries. 

What does Spiractin contain?

Spiractin tablets 25mg contain the active ingredient spironolactone, a potassium-sparing diuretic used to treat oedema in various conditions.  They also contain quinoline yellow, sunset yellow, erythrosine, polysorbate, peppermint oil, povidone, microcrystalline cellulose, maize starch, sodium starch glycollate, talc, magnesium stearate and lactose.

Treating oedema with Spiractin

Spiractin tablets 25mg contain spironolactone, a potassium-sparing diuretic (water pill) that is used to treat fluid retention (oedema) caused by several conditions, including congestive heart failure, hypertension (high blood pressure), liver cirrhosis and kidney disease.  Spironolactone in Spiractin tablets 25mg works by blocking the action of the hormone aldosterone on the kidneys, which increases excretion of excess water and sodium from the body while at the same time maintaining blood potassium levels. 

Spiractin for hypertension

Spiractin tablets 25mg contain spironolactone, a potassium-sparing diuretic that is used to treat hypertension or high blood pressure, which increases risk of cardiovascular disease and if uncontrolled can cause kidney damage, stroke, heart attack and heart failure.  Spironolactone in Spiractin tablets 25mg binds to the receptor for the hormone aldosterone on the kidneys, blocking the action of aldosterone, which increases sodium excretion and reduces potassium loss at the distal renal tubule of the kidney.  This action of spironolactone in Spiractin tablets 25mg increases water excretion in the urine which reduces fluid build-up in the tissues, increase blood potassium levels and lowers blood pressure. 

Spiractin for transgender treatment

Spiractin tablets 25mg contain spironolactone, which is primarily used as a diuretic, to reduce fluid retention in conditions such as congestive heart failure, hypertension (high blood pressure), liver cirrhosis and kidney disease.  Spironolactone in Spiractin tablets 25mg also acts as an anti-androgen by binding to the androgen receptor and competing with dihydrotestosterone (DHT), the active metabolite of testosterone, which promotes male characteristics, thereby blocking the action of DHT.  Using an anti-androgen like spironolactone (usually in high doses of 200–400 mg per day) allows the amount of oestrogen administered for feminising hormone therapy to be reduced while optimising the hormone regime needed to stimulate breast development, feminisation of skin, and female fat distribution. 

What are the side effects of Spiractin?

The most commonly reported side effects when taking Spiractin includes nausea, vomiting, headache, abdominal cramps and pain, diarrhoea, headache, drowsiness, lethargy, hair loss and excessive hair growth.  Other side effects include skin rash, menstrual period changes in women, breast enlargement (gynaecomastia) and sexual problems (impotence) in men.

When should Spiractin not be used?

You should not use Spiractin tablets 25mg if you:

  • are allergic to spironolactone or any ingredients in Spiractin
  • are pregnant or are breastfeeding
  • have kidney or liver disease
  • have high potassium levels in your blood due to a potassium rich diet or if you are taking medications or supplements that increase blood potassium levels
  • are not producing or passing urine
  • are taking other medications that may interact with Spiractin, such as potassium supplements, non-steroidal anti-inflammatory drugs like indomethacin or mefenamic acid, aspirin, digoxin for heart failure, carbenoxolone for mouth ulcers, other diuretics, the ACE inhibitors antihypertensives, ammonium chloride in some cough medications, cholestyramine for lowering blood cholesterol

What medications interact with Spiractin?

Several medications interact with Spiractin tablets 25mg and should either not be taken while you are taking Spiractin or only after discussion and instruction from your doctor:

  • Drugs that cause a serious reaction with Spiractin: potassium supplements, ammonium chloride in some cough medications, cholestyramine for lowering blood cholesterol, the ACE inhibitors antihypertensives
  • Drugs that affect Spiractin: non-steroidal anti-inflammatory drugs like indomethacin or mefenamic acid and aspirin, carbenoxolone for mouth ulcers
  • Drugs that are affected by Spiractin: digoxin for heart failure

How should Spiractin be taken?

You should take your Spiractin tablets 25mg with a glass of water with or without food, once or twice daily.  The dose you take depends on your condition and what you are being treated for and should be as recommended by your doctor.  You should continue taking your Spiractin tablets 25mg even if you are feeling well, which may be for a few days or several weeks and your doctor may increase your dose during treatment. 

How long should you take Spiractin?

You should continue taking your Spiractin tablets 25mg even if you are feeling well, which may be for a few days or several weeks and your doctor may increase your dose during treatment. 

Missed dose of Spiractin

If you miss a dose of Spiractin tablets 25mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Spiractin be stored?

You should store your Spiractin tablets 25mg below 30°C in a cool dry place. 

 

 

Cardinol 160 LA (Propranolol)

Cardinol general information

What is Cardinol used for?

Cardinol 160mg capsules are used to treat a variety of conditions including, control of hypertension (high blood pressure); management of angina (chest pain) and long-term prevention of myocardial infarction (heart attack). Cardinol capsules 160 LA work through a common mechanism in several different body systems to manage the condition and relieve symptoms by reducing heart rate (pulse), workload (force needed to pump) and oxygen demand, increasing blood flow and lowering blood pressure.

How does Cardinol work?

Cardinol capsules 160mg contain propanolol, which is a beta-blocker or selective beta-receptor antagonist and acts by blocking the action of chemicals called catecholamines, such as adrenaline (epinephrine), which are released by the adrenal glands in response to nerve stimulation during physical and mental stress. Adrenaline works via beta-receptors in the heart to stimulate increased heart rate and constriction (narrowing) of blood vessels. These actions of adrenaline are blocked by propanolol in Cardinol capsules 160mg, to slow heart rate, dilate (widen) blood vessels, lower blood pressure, and increase blood flow and oxygen to the heart. Since beta-receptors are found in many tissues, particularly the heart, kidneys, vascular smooth muscle in blood vessel walls, lung, skeletal muscle and liver, all short-term and long-term symptom relief due to taking Cardinol capsules 160 LA, is based on blocking beta-receptors in the target tissue. Cardinol capsules 160mg are formulated for long acting slow release of propanolol over a 24 hour period so that you need only take one capsule a day.

What Cardinol doses are available?

Cardinol is available to order and buy online from Inhouse Pharmacy in the following doses:
  • Cardinol 10mg tablets
  • Cardinol 40mg tablets
  • Cardinol 160mg capsules (long-acting slow release)

What does Cardinol contain?

Cardinol 160mg capsules contain spheroids of the active ingredient propanolol hydrochloride, a beta-blocker and beta-receptor agonist that blocks the action of adrenaline to slow heart rate and relax blood vessels, amongst other actions. These spheroids have a sustained release coating to provide long action. Propanolol Cardinol 160mg capsules also contain sucrose, maize starch, shellac, talc and the gelatin capsule.

What is the difference between Cardinol long acting capsules and Cardinol tablets?

Cardinol tablets are formulated for rapid release and absorption and contain lower concentrations of active ingredient than capsules. Cardinol capsules contain slow release spheroids which release the active ingredient over a longer time period for slower but sustained drug absorption, which means that you need only take one capsule a day to get the same dose of drug as several tablets taken each day.

Treating high blood pressure (hypertension) with Cardinol

Cardinol capsules 160mg contain propanolol, a beta-blocker that blocks the action of adrenaline in stimulating beta-receptors in blood vessel walls, causing blood vessels to constrict (narrow) which reduces blood flow and raises blood pressure. Cardinol capsules 160 LA are used to treat high blood pressure (hypertension) by widening blood vessels, reducing heart rate (number of heart beats) and reducing the force of the heart contraction. These actions lower blood pressure and help the heart to cope better,
Reducing heart rate with Cardinol
Cardinol 160mg capsules contain propanolol, a beta-blocker that blocks the action of adrenaline in stimulating beta-receptors in the heart muscle. Adrenaline increases heart rate and the strength of muscular contraction in response to excitement/physical exertion. Cardinol capsules 160 LA are used for management of angina (chest pain) and long-term prevention of myocardial infarction (heart attack) by widening blood vessels, reducing heart rate and the force of contraction of the heart. When the heart does not have to work as hard, it requires less oxygen and relieves symptoms of angina including chest pain and breathlessness on exertion.

What are the side effects of Cardinol?

The mot common side effects reported while taking Cardinol capsules 160mg include: tiredness, dizziness, sleep disturbances or nightmares, hair loss, mood changes or confusion, dry eyes, nausea, vomiting, diarrhoea, stomach pain.

When should Cardinol not be used?

You should not use Cardinol capsules 160mg if you:
  • are allergic to propranolol hydrochloride or any other ingredients in Cardinol 160 LA
  • have a history of bronchial asthma or bronchospasm
  • are diabetic and taking hypoglycaemic therapy as propranolol may prolong the hypoglycaemic response to insulin
  • have, poor peripheral blood circulation, uncontrolled heart failure, low blood pressure (hypotension), metabolic acidosis (too much acid in your blood) or a certain type of angina called Prinzmetal's angina
  • have a phaeochromocytoma (a rare tumour of the adrenal gland) which is not already being treated with other medicines
  • have certain other heart problems
  • are taking medication that may interact with Cardinol 160mg capsules, including: other medicines for high blood pressure; angina or an irregular heart beat such as calcium channel blockers (disopyramide) digoxin, clonidine, hydralazine, diltiazem, verapamil, and nifedipine; adrenaline for emergencies like anaphylaxis; ergotamine and derivatives for migraine; antiinflammatories like ibuprofen or indomethacin; cimetidine for reflux and ulcers; chlorpromazine for psychiatric disorders

How should Cardinol be taken?

You should take your Cardinol capsules 160mg with a glass of water, swallowed whole with or without food, usually once daily either morning or evening, but at the same time each day. You should take Cardinol capsules 160 LA according to your doctor’s recommendations and the number of capsules you take each day, how often you take them and for how long depends on the condition you are being treated for. The dose you are taking may be increased by your doctor. You must take your capsules every day, as instructed and if you are advised to stop taking them, withdrawal should be gradual and treatment should not be discontinued abruptly.

How long should you take Cardinol?

You should take your Cardinol capsules 160mg for as long as your doctor recommendations, which may be for a few days or weeks, depending on the condition you are being treated for.

Missed dose of Cardinol

If you miss a dose of Cardinol capsules 160mg, take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How Cardinol name be stored?

You should store your Cardinol capsules 160mg below 25°C, protected from light and moisture.


Inderal 40 (Propranolol 40mg)

Inderal general information

What is Inderal used for?

Inderal tablets 40mg are used to treat a variety of heart conditions including control of hypertension (high blood pressure); management of angina (chest pain); long-term prevention of myocardial infarction (heart attack); and control of most forms of arrhythmias and dysrhythmias (irregular heart beat or rhythm). Inderal 40 is also used for reducing anxiety, preventing of migraine, treating certain tremor conditions and controlling thyrotoxicosis (overactive thyroid). Inderal tablets 40mg work through a common mechanism in several different body systems to manage the condition and relieve symptoms by reducing heart rate (pulse), workload on the heart (force needed to pump) and oxygen demand by the heart, increasing blood flow and lowering blood pressure.

How does Inderal work?

Inderal tablets 40mg contain propanolol, which is a beta-blocker or selective beta1-receptor antagonist and acts by blocking the action of chemicals called catecholamines, such as adrenaline (epinephrine), which are released by the adrenal glands in response to nerve stimulation during physical and mental stress. Adrenaline works via beta-receptors in the heart to stimulate increased heart rate and constriction (narrowing) of blood vessels. These actions of adrenaline are blocked by propanolol in Inderal tablets 40mg, to slow heart rate, dilate (widen) blood vessels, lower blood pressure, and increase blood flow and oxygen to the heart. Since beta-receptors are found in many tissues, particularly the heart, kidneys, vascular smooth muscle in blood vessel walls, lung, skeletal muscle and liver, all short-term and long-term symptom relief due to taking Inderal tablets 40mg, is based on blocking beta-receptors in the target tissue.

What Inderal doses are available?

Inderal is available to order and buy online from Inhouse Pharmacy in the following doses:
  • Inderal 10mg tablets
  • Inderal 40mg tablets

What does Inderal contain?

Inderal tablets 40mg contain the active ingredient propanolol hydrochloride, which is a beta-blocker that blocks the action of adrenaline to slow heart rate and relax blood vessels, amongst other actions.

Treating high blood pressure (hypertension) with Inderal

Inderal tablets 40mg contain propanolol, a beta-blocker that blocks the action of adrenaline (epinephrine); released by the adrenal glands in response to nerve stimulation (for example due to stress). Adrenaline stimulates beta-receptors in blood vessel walls, causing blood vessels to constrict (narrow) which reduces blood flow and raises blood pressure. Inderal 40mg tablets are used to treat high blood pressure (hypertension) by widening blood vessels (vasodilation), reducing heart rate (number of heart beats) and reducing the force of the heart contraction. These actions lower blood pressure and help the heart to cope better.

Reducing heart rate with Inderal

Inderal 40mg tablets contain propanolol, a beta-blocker that blocks the action of adrenaline (epinephrine); released by the adrenal glands in response to nerve stimulation (for example due to stress). Adrenaline stimulates beta-receptors in the heart muscle, which increases heart rate and the strength of muscular contraction in response to excitement/physical exertion. Inderal tablets 40mg are used to reduce tachycardia (racing heart) in conditions such as anxiety and help stabilise arrhythmias and dysrhythmias (irregular heart beat or rhythm). Inderal 40 is used for management of angina (chest pain) and long-term prevention of myocardial infarction (heart attack) by reducing heart rate and force of contraction of the heart, and widening blood vessels. When the heart does not have to work as hard, it requires less oxygen and the reduced workload relieves symptoms of angina, such as breathlessness on exertion.

What are the side effects of Inderal?

The most common side effects reported while taking Inderal tablets 40mg include: ttiredness, dizziness, sleep disturbances or nightmares, hair loss, mood changes or confusion, dry eyes, nausea, vomiting, diarrhoea, stomach pain.

When should Inderal not be used?

You should not use Inderal tablets 40mg if you:
  • are allergic to propranolol hydrochloride or any other ingredients in Inderal 40
  • have a history of bronchial asthma or bronchospasm
  • are diabetic and taking hypoglycaemic therapy as propranolol may prolong the hypoglycaemic response to insulin
  • have, poor peripheral blood circulation, uncontrolled heart failure, low blood pressure (hypotension), metabolic acidosis (too much acid in your blood) or a certain type of angina called Prinzmetal's angina
  • have a phaeochromocytoma (a rare tumour of the adrenal gland) which is not already being treated with other medicines
  • have certain other heart problems
  • are taking medication that may interact with Inderal 40mg tablets, including: other medicines for high blood pressure; angina or an irregular heart beat such as calcium channel blockers (disopyramide) digoxin, clonidine, hydralazine, diltiazem, verapamil, and nifedipine; adrenaline for emergencies like anaphylaxis; ergotamine and derivatives for migraine; antiinflammatories like ibuprofen or indomethacin; cimetidine for reflux and ulcers; chlorpromazine for psychiatric disorders.

How should Inderal be taken?

You should take your Inderal 40mg tablets with a glass of water, with or without food. You should take Inderal 40 according to your doctor’s recommendations and the number of tablets you take each day, how often you take them and for how long depends on the condition you are being treated for. The dose you are taking may be increased by your doctor. You must take your Inderal 40mg tablets every day, as instructed and if you are advised to stop taking them, withdrawal should be gradual and treatment should not be discontinued abruptly.

How long should you take Inderal?

You should take your Inderal tablets 40mg for as long as your doctor recommendations, which may be for a few days or weeks, depending on the condition you are being treated for. You must take your Inderal 40mg tablets every day, as instructed and if you are advised to stop taking them, withdrawal should be gradual and treatment should not be discontinued abruptly.

Missed dose of Inderal

If you miss a dose of Inderal tablets 40mg, take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How Inderal be stored?

You should store your Inderal 40mg tablets below 25°C, protected from light and moisture.

Itrazole 100mg (Itraconazole)

Itrazole general information

What is Itrazole used for?

Itrazole capsules 100mg are used to treat a variety of superficial and systemic fungal infections in various parts of the body. Fungal infections that Itrazole 100 is used for include:
  • Persistent infections of the skin with pityriasis versicolor, which caused by the yeast-like fungus malassezia and characterised by rash and patches of flaky skin on the trunk, neck or arms.
  • Persistent infections with the fungus tinea (also called ringworm) in various parts of the body including the body (tinea corporis), foot (tinea pedis) and groin (tinea cruris or jock itch).
  • Candidiasis (thrush) of the mucus membranes such as in the mouth and vagina, also of the skin.
  • Persistent infections of the vagina with the yeast candida (candidiasis).
  • Infection of the nail (onychomycosis) with yeast or dermatophyte fungi like tinea.
  • Fungal keratitis, an infection of the cornea of the eye by mould fungi like aspergillus or the yeast Candida, resulting in inflammation.
  • Systemic fungal infections that can affect internal organs such as histoplasmosis a rare systemic fungal infection from inhalation of a soil fungus into the lung causing flu-like symptoms; also aspergillosis, a lung infection caused by breathing in spores of the mould fungus aspergillus. These systemic fungal infections are more common in people who are immunocompromised.

How does Itrazole work?

Itrazole capsules 100mg contain itraconazole broad-spectrum antifungal drug belonging to the triazole group of antifungals. Itraconazole in Itrazole capsules 100mg is a potent and specific inhibitor of fungal enzymes necessary for the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells. A lack of ergosterol weakens the fungal cell membrane, causing the cell contents to leak out, which kills the fungus. This prevents the infection from spreading, relieving symptoms caused by the infection, including, itching and inflammation.

What does Itrazole contain?

Itrazole capsules 100mg contain the active ingredient itraconazole a broad-spectrum antifungal drug, used to treat and prevent a variety of fungal infections. They also contain sugar spheres, hydroxypropylmethyl cellulose, sorbitan stearate, hydrated silica colloidal, titanium dioxide, red iron oxide and gelatin and opacode S-1-7078 White.

Treating fungal infections with with Itrazole

Itrazole capsules 100mg contain itraconazole, a broad-spectrum antifungal drug that is used to treat a wide range of superficial and systemic fungal infections, caused by a variety of susceptible fungal species. Itrazole capsules 100mg specifically inhibit the synthesis of ergosterol, an important component of fungal cell membrane, which kills the fungus and stops it spreading; relieving the itching, scaling and other more severe symptoms caused by the fungal infection. Fungal infections that can be treated with Itrazole capsules 100mg include:
  • Persistent infections of the skin with pityriasis versicolor, which caused by the yeast-like fungus malassezia and characterised by rash and patches of flaky skin on the trunk, neck or arms.
  • Persistent infections with the fungus tinea (also called ringworm) in various parts of the body including the body (tinea corporis), foot (tinea pedis) and groin (tinea cruris or jock itch).
  • Candidiasis (thrush) of the mucus membranes such as in the mouth and vagina, also of the skin.
  • Persistent infections of the vagina with the yeast candida (candidiasis).
  • Infection of the nail (onychomycosis) with yeast or dermatophyte fungi like tinea.
  • Fungal keratitis, an infection of the cornea of the eye by mould fungi like aspergillus or the yeast Candida, resulting in inflammation.
  • Systemic fungal infections that can affect internal organs such as histoplasmosis a rare systemic fungal infection from inhalation of a soil fungus into the lung causing flu-like symptoms; also aspergillosis, a lung infection caused by breathing in spores of the mould fungus Aspergillus. These systemic fungal infections are more common in people who are immunocompromised.

Itrazole for thrush

Itrazole capsules 100mg contain itraconazole, a synthetic broad-spectrum antifungal agent that is used to treat a variety of fungal infections including thrush or candidiasis, which is caused by the yeast candida albicans. Although any site on the body can become infected with candida, including the gastrointestinal tract, the most common site of infection are the mucous membranes of the mouth and vagina, with symptoms including creamy/white lesions or discharge and itching or irritation. Itrazole capsules 100mg specifically inhibit the synthesis of ergosterol, an important component of fungal cell membrane, which kills the fungus and stops it spreading. In this way Itrazole capsules 100mg relieves the symptoms of thrush in all its locations, and prevents constant reinfection in chronic recurrent vaginal thrush.

What are the side effects of Itrazole?

The most commonly reported side effects when taking Itrazole capsules 100mg include: upset stomach, stomach cramps, nausea and vomiting, diarrhoea, skin rash, headache, constipation, dizziness, menstrual disorders.

When should Itrazole not be used?

You should not use Itrazole capsules 100mg if you:
  • are allergic to itraconazole or any other azole drug or any ingredients in Itrazole
  • are pregnant or are breastfeeding, without discussion with your doctor
  • have kidney or liver disease
  • are taking medicines that interact with Itrazole, including, the antiviral rifampicin, rifabutin or zidovudine; terfenadine or astemizole for allergy, cisapride for reflux, the anticonvulsant phenytoin, the diuretic hydrochlorothiazide, medicines for diabetes such as glipizide, tolbutamide or glibenclamide, theophylline for asthma, the immunosuppressants tacrolimus and cyclosporine, some benzodiazepines such as midazolam, cholesterol lowering drugs like simvastatin and lovastatin, ergotamine for migraine or ergometrine to prevent bleeding after childbirth, the calcium channel blocker nisoldipine for high blood pressure and angina, the antibiotics clarithromycin and erythromycin, the antipsychotic pimozide

What medications interact with Itrazole?

Several medications interact with Itrazole and should either not be taken while you are taking Itrazole or only after discussion and instruction from your doctor:
  • Drugs that cause a serious reaction with Itrazole: cisapride for reflux can cause heart problems
  • Drugs that affect Itrazole: the anticonvulsant phenytoin, the antiviral rifampicin, rifabutin or zidovudine; the diuretic hydrochlorothiazide, the antibiotics clarithromycin and erythromycin
  • Drugs that are affected by Itrazole: medicines for diabetes such as glipizide, tolbutamide or glibenclamide; theophylline for asthma, immunosuppressants tacrolimus and cyclosporine, some benzodiazepines such as midazolam, cholesterol lowering drugs like simvastatin and lovastatin, ergot alkaloids like ergotamine for migraine or ergometrine to prevent bleeding after childbirth, the calcium channel blocker nisoldipine for high blood pressure and angina, the antipsychotic pimozide

How should Itrazole be taken?

You should take your Itrazole capsules 100mg swallowed whole with a glass of water and with food once or twice daily depending on what you are being treated and on your doctor’s recommendations. The dose you take and for how long depends on the type and severity of your infection and your doctor’s recommendations. You should always finish your course of Itrazole capsules 100mg, which may be for a few days or weeks, if not, the infection may not clear up completely.

How long should you take Itrazole?

You should always finish your course of Itrazole capsules 100mg, which may be for a few days or weeks, if not, the infection may not clear up completely.

Missed dose of Itrazole

If you miss a dose of Itrazole capsules 100mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Itrazole be stored?

You should store your Itrazole below 25°C in a cool dry place.


All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
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Select the currency that you would like to display the prices in. This will be the currency that appears on your credit card statement.