Your Country: ?
Your Currency: ?
CONTACT US
USA: 877 271 6591
UK: 0808 234 7254
Outside UK/USA: 1 877 271 6591
  Lines open in 1 hour 32 min
Your Country: ?
Your Currency: ?
Login | SHOPPING CART    (0 items)
USA: 877 271 6591
UK: 0808 234 7254
Outside UK/USA: 1 877 271 6591
  Lines open in 1 hour 32 min
Your Country: Your Currency:
Ask us a question 877-271-6591 or 800-868-9064
  Lines open in 1 hour 32 min
Login | SHOPPING CART    (0 items)
FREE SHIPPING TO UNITED STATES
Esperal (Disulfiram 250mg) 10 Tablets/Strip


Esperal (Disulfiram 250mg) 10 Tablets/Strip

Esperal (Disulfiram 250mg) Tablets

 
 

Product Name
Esperal (Disulfiram 250mg) 10 Tablets/Strip
Also known as Antabuse
Active Ingredient
Disulfiram
Manufacturer
Torrent Pharmaceuticals
Product Type
Deterrent to alcohol consumption
Product expiry date we are currently shipping
Currently out of stock. New stock expected 20 Jan 2020.

Esperal tablets 250mg contain disulfiram that blocks the metabolism of alcohol and is used to treat chronic alcohol dependence, by causing an unpleasant reaction in combination with alcohol ingestion to act as a deterrent.

Product Price List
REMEMBER SHIPPING IS FREE!

Esperal (Disulfiram) 250mg 100 Tablets
$0.47 per Tablet
|
$47.00 (USD) 
$47.00 (USD) 
Esperal (Disulfiram) 250mg 200 Tablets
$0.40 per Tablet
|
$79.50 (USD) 
$79.50 (USD) 
Esperal (Disulfiram) 250mg 300 Tablets
$0.32 per Tablet
|
$95.00 (USD) 
$95.00 (USD) 
Let us notify you when this product is back in stock
Unfortunately, Esperal (Disulfiram 250mg) Tablets is currently out of stock. Please enter your email address below and we will notify you when more stock becomes available.
Your email address:

Esperal general information

What is Esperal used for?

Esperal tablets 250mg are used to treat and manage chronic alcohol dependence as part of an integrated programme of counselling and rehabilitation, to help alcoholics remain alcohol free once they have given up drinking alcohol.  Alcohol dependence or alcoholism is considered an addictive disease that can result in physical and psychological addiction to alcohol.  This addiction can influence all aspects of life, causing dysfunctional behaviour and affecting relationships and the workplace.  Alcoholism has recognisable symptoms, including inability to stop drinking, the need to drink more for the same effect, craving alcohol above anything else.  If the interval between drinks increases or attempts are made to give up drinking suddenly, then stopping alcohol drinking can lead to severe withdrawal symptoms, such as anxiety, sweating, tremor, tachycardia (increased pulse rate) and, nausea.  Esperal tablets 250mg are intended to be used to help break the habit of alcohol dependency by acting as a deterrent to drinking alcohol but they will only be effective as part of a supportive programme and requires commitment and motivation to remain alcohol free.  1, 2

How does Esperal work?

Esperal tablets 250mg contain disulfiram, a prodrug that is used to treat alcoholism to help break the habit alcohol dependency.  Disulfiram in Esperal tablets 250mg is rapidly metabolised once ingested into diethyldithiocarbamate (DDC) and works by blocking the metabolism of alcohol, which produces an acute sensitivity to alcohol with unpleasant side effects.  Alcohol is normally metabolised in the liver to acetaldehyde by the action of the enzyme alcohol dehydrogenase and acetaldehyde is further metabolised to acetic acid by the action of the enzyme acetaldehyde dehydrogenase.  Disulfiram in Esperal tablets 250mg inhibits the action of acetaldehyde dehydrogenase, resulting in the build-up of acetaldehyde, which is responsible for the unpleasant symptoms associated with excess alcohol consumption and the hangover effect.  It is also thought that Disulfiram in Esperal tablets 250mg has other metabolic effects that contribute to the unpleasant reactions associated with treatment with Esperal tablets 250mg including flushing of the face, a feeling of difficulty in breathing, palpitations, a throbbing headache, nausea and vomiting.  These effects are intended to act as a deterrent to continued alcohol abuse as they continue while drinking alcohol at the same time as taking Esperal tablets 250mg and the unpleasant effects can last for several hours and up to three weeks after Esperal tablets 250mg are no longer taken.  

What does Esperal contain?

Esperal tablets 250mg contains the active ingredient disulfiram, used to treat alcohol dependence. 

Treating alcohol dependence with Esperal

Esperal tablets 250mg contain disulfiram that is used to treat alcohol dependence as part of an integrated programme of counselling and rehabilitation, to help alcoholics remain alcohol free once they have given up drinking alcohol.  Alcohol dependence or alcoholism is an addictive disease that causes dysfunctional behaviour affecting all aspects of life including, relationships and the workplace and has recognisable symptoms, including inability to stop drinking, the need to drink more for the same effect, craving alcohol above anything else and withdrawal symptoms, such as anxiety, sweating, tremor, tachycardia (increased pulse rate), nausea, if the interval between drinks increases or attempts are made to give up drinking.  Disulfiram in Esperal tablets 250mg works by blocking the metabolism of alcohol, which produces unpleasant reactions if alcohol is ingested and include flushing of the face, a feeling of difficulty in breathing, palpitations, a throbbing headache, nausea and vomiting.  These reactions are intended to act as a deterrent to continued alcohol abuse and can last for several hours and up to three weeks after Esperal 250 is no longer taken.  Esperal tablets 250mg should only be used as an aid to giving up alcohol as part of an overall supportive programme.

What are the side effects of Esperal?

The most commonly reported side effects when taking Esperal tablets 250mg include drowsiness, fatigue, numbness, tingling, pain or weakness in hands or feet (peripheral neuritis, polyneuritis), peripheral neuropathy, skin rash, eye pain or tenderness and changes in vision (optic neuritis), mood and changes, jaundice, impotence, headache, stomach upset, bad breath (halitosis), dizziness

When should Esperal not be used?

You should not use Esperal tablets 250mg if you:

  • are allergic to disulfiram or any ingredients in Esperal
  • are sensitive to other thiuram derivatives used in pesticides and rubber production
  • are pregnant or are breastfeeding
  • have kidney or liver disease
  • have consumed alcohol within 24 hours
  • have used any alcohol-containing food, sauces, remedies, tonics, toiletries, perfumes or sprays within the previous 24 hours
  • have severe heart disease or heart failure
  • have had a stroke or other serious brain disorder
  • have a mood or personality disorder
  • are taking medicines that interact with Esperal, including phenytoin for seizures, isoniazid for tuberculosis treatment, benzodiazepines like diazepam for anxiety, the antibiotic metronidazole, anticoagulants like warfarin, the sedative paraldehyde.

What medications interact with Esperal?

Several medications interact with Esperal tablets 250mg and should either not be taken while you are taking Esperal or only after discussion and instruction from your doctor:

  • Drugs that cause a serious reaction with Esperal: isoniazid for tuberculosis treatment, the antibiotic metronidazole, the sedative paraldehyde
  • Drugs that are affected by Esperal: phenytoin for seizures, benzodiazepines like diazepam for anxiety, anticoagulants like warfarin

How should Esperal be taken?

You should begin your treatment with Esperal tablets 250mg only after you have stopped drinking any alcohol for at least 24 hours before the first dose.  You should take your Esperal tablets 250mg dissolved in a quarter glass of water or fruit juice, preferably on waking in the morning, and drink immediately.  If the prescribed dose has a sedative effect, you can take your Esperal tablets 250mg at bedtime.  The dose you take will be reduced after the first few days and then you should continue to take your Esperal tablets 250mg for as long as recommended by your doctor, usually from 6 weeks up to 6 months.

How long should you take Esperal?

You should continue to take your Esperal tablets 250mg for as long as recommended by your doctor, usually from 6 weeks up to 6 months.

Missed dose of Esperal

If you miss a dose of Esperal tablets 250mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Esperal be stored?

You should store your Esperal tablets 250mg below 25°C in a cool dry place. 

References

  1. Krampe H, Stawicki S, Wagner T, Bartels C, Aust C, Rüther E, Poser W, Ehrenreich H.  Follow-up of 180 alcoholic patients for up to 7 years after outpatient treatment: impact of alcohol deterrents on outcome.  Alcohol Clin Exp Res 2506; 30: 86-95.
  2. Jørgensen CH, Pedersen B, Tønnesen H. The efficacy of disulfiram for the treatment of alcohol use disorder. Alcohol Clin Exp Res 2011; 35:1749-58
Other products in
General -> General Medications
All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
What is this ?
Please select your country to display all the products we are able to supply to you.
What is this ?
Select the currency that you would like to display the prices in. This will be the currency that appears on your credit card statement.
 

This website uses cookies. View our policy and select your preferences here